|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several murine retinoblastoma models have been generated by deleting the genes encoding for retinoblastoma susceptibility protein pRb and one of its family members p107 or p130.
|
27750399 |
2017 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
While mutations in the retinoblastoma (RB1) tumor suppressor have been reported in lung cancer, mainly in small cell lung carcinoma, the tumor suppressive role of its relatives p107 and p130 is still a matter of debate.
|
27966456 |
2017 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In mice, inactivation of one allele of Arf cooperated with Rb and p107 loss to rapidly accelerate retinoblastoma, with frequent loss of heterozygosity (LOH) at the Arf locus.
|
22484813 |
2012 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review portrays an updated overview about the possible tumor suppressive properties of the Rb2/p130 gene, the third member of the retinoblastoma (RB) family of genes, including RB itself and p107.
|
11406530 |
2001 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
With the aim of identifying novel molecular mechanisms of hepatocyte transformation by HCV, we examined the effect of HCV core protein on the expression of the whole Retinoblastoma (RB) family of tumor and growth suppressor factors, i.e. pRb, p107 and pRb2/p130.
|
26576645 |
2015 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The retinoblastoma (Rb) family consists of the tumor suppressor Rb/p105 and related proteins p107 and Rb2/p130.
|
12769348 |
2003 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
UL97 phosphorylates Rb, p107 and p130, thereby inactivating all three retinoblastoma (Rb) family members.
|
28946006 |
2017 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Animals lacking Rb and/or its family members p107 and p130 have led scientists to uncover new and exciting roles for this protein family in development as well as tumor suppression.
|
16465443 |
2006 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The RB/p105 and p107 genes of the retinoblastoma family are tumor suppressor genes whose proteins are inactivated by interaction with T-antigen proteins encoded by polyomaviruses (e.g., simian virus 40 and human JC virus), which have been found to be highly tumorigenic in animals.
|
9776410 |
1998 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, UV-induced expression from the reporter construct appears impaired in murine fibroblasts harboring inactivating mutations in the retinoblastoma (Rb) gene family members p107 and pRb but not in fibroblasts harboring such mutations in the p53 gene.
|
12870848 |
2003 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further investigation into the mechanisms of MAGE-A11 function in prostate cancer demonstrated interactions with the retinoblastoma-related protein p107 and Rb tumor suppressor but no interaction with p130 of the Rb family.
|
23853093 |
2013 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The retinoblastoma (Rb) family consists of the tumor suppressor pRb/p105 and related proteins p107 and pRb2/p130.
|
10667590 |
2000 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The activity of E2F factors is regulated through association with the retinoblastoma tumor suppressor protein (Rb) and the other pocket proteins, p107 and p130.
|
9556498 |
1998 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The human cytomegalovirus pp71 protein employs an LXCXD motif to attack the retinoblastoma family members and induce DNA synthesis in quiescent cells. pp71 binds to and induces the degradation of the hypophosphorylated forms of the retinoblastoma protein and its family members p107 and p130 in a proteasome-dependent manner.
|
12612064 |
2003 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since this residue is conserved in murine RB and in the related p107 protein, we studied the activity of in vitro mutants flanking this position.
|
1334491 |
1992 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We will focus on recent demonstrations regarding the involvement of the retinoblastoma family proteins (phosphorylated retinoblastoma (pRb), p107 and pRb2/p130) at different levels of the angiogenic process. pRb and its homologs can regulate the expression of pro- and antiangiogenic factors, such as the vascular endothelial growth factor, through an E2F-dependent mechanism.
|
16936754 |
2006 |
|
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two genes, p107 and Rb2/p130, are strictly related to RB, the most investigated tumor suppressor gene, responsible for susceptibility to retinoblastoma.
|
8872613 |
1996 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The best-known cellular targets of the HPV-16 E7 oncoprotein are the retinoblastoma tumor suppressor protein pRB and the related pocket proteins p107 and p130.
|
16061792 |
2005 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transcription factor DRTF1/E2F coordinates events in the cell cycle with transcription by its cyclical interactions with important regulators of cellular proliferation like the retinoblastoma tumour-suppressor gene product (Rb) and the Rb-related protein, p107 (refs 1-8).
|
8446173 |
1993 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unexpectedly, removing Vhl suppressed retinoblastoma formation in murine Rb1/Rbl1-deficient retina but generated subretinal vascular growths resembling retinal angiomatous proliferation (RAP) and retinal capillary hemangioblastoma (RCH).
|
31613797 |
2019 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
UL97 strongly interacts with p107 but not Rb or p130.
|
28289097 |
2017 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we have found that acute inactivation of retinoblastoma (Rb) family proteins (Rb, p107 and p130) in mouse postmitotic neurons leads to cell death after S-phase progression.
|
28928282 |
2017 |
|
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Structure of the human retinoblastoma-related p107 gene and its intragenic deletion in a B-cell lymphoma cell line.
|
10863094 |
2000 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A combined deletion of the RB proteins, RB, p107 and p130 (triple-mutant; TM), prevents SATB1-induced G1 arrest, which is restored upon the reintroduction of RB into SATB1-expressing TM fibroblasts.
|
23686316 |
2013 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings provide formal proof for the role of loss of Rb in retinoblastoma development in the mouse and the first in vivo evidence that p107 can exert a tumor suppressor function.
|
9620848 |
1998 |