|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consequently, it leads to the resistance of p107 KO mice to high-fat diet effects, prevention of liver steatosis, and improvement of the lipid profile and glucose homeostasis.
|
30383332 |
2019 |
|
leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Leukemia growth is inhibited by benzoxime without causing any harmful effect in rats bearing RBL-1 ×enotransplants.
|
30675257 |
2019 |
|
Hemangioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Rb1/Rbl1/Vhl loss induces mouse subretinal angiomatous proliferation and hemangioblastoma.
|
31613797 |
2019 |
|
Childhood Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Leukemia growth is inhibited by benzoxime without causing any harmful effect in rats bearing RBL-1 ×enotransplants.
|
30675257 |
2019 |
|
Retinal hemangioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Unexpectedly, removing Vhl suppressed retinoblastoma formation in murine Rb1/Rbl1-deficient retina but generated subretinal vascular growths resembling retinal angiomatous proliferation (RAP) and retinal capillary hemangioblastoma (RCH).
|
31613797 |
2019 |
|
Retinal angiomatous proliferation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Unexpectedly, removing Vhl suppressed retinoblastoma formation in murine Rb1/Rbl1-deficient retina but generated subretinal vascular growths resembling retinal angiomatous proliferation (RAP) and retinal capillary hemangioblastoma (RCH).
|
31613797 |
2019 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consequently, it leads to the resistance of p107 KO mice to high-fat diet effects, prevention of liver steatosis, and improvement of the lipid profile and glucose homeostasis.
|
30383332 |
2019 |
|
Malignant neoplasm of breast
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Our methylation analysis indicates that only promoters of RBL1 (p107), RASSF1A, and cyclin D2 were aberrantly methylated in studied breast cancer cell lines.
|
28218039 |
2017 |
|
Breast Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Our methylation analysis indicates that only promoters of RBL1 (p107), RASSF1A, and cyclin D2 were aberrantly methylated in studied breast cancer cell lines.
|
28218039 |
2017 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
With the aim of identifying novel molecular mechanisms of hepatocyte transformation by HCV, we examined the effect of HCV core protein on the expression of the whole Retinoblastoma (RB) family of tumor and growth suppressor factors, i.e. pRb, p107 and pRb2/p130.
|
26576645 |
2015 |
|
Malignant Head and Neck Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that pRb and p107 act together to efficiently suppress head and neck cancer and are, therefore, highly relevant targets of HPV-16 E7 in its contribution to HPV-positive HNSCC.
|
22237625 |
2012 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In this study, we characterized the cancer susceptibility of mice deficient in the expression of pRb and either of two related "pocket" proteins, p107 and p130, that are also inactivated by E7. pRb/p107-deficient mice developed head and neck cancer as frequently as do HPV-16 E7 transgenic mice.
|
22237625 |
2012 |
|
Head and Neck Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that pRb and p107 act together to efficiently suppress head and neck cancer and are, therefore, highly relevant targets of HPV-16 E7 in its contribution to HPV-positive HNSCC.
|
22237625 |
2012 |
|
Mammary Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells.
|
16537896 |
2006 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
For the first time, we tested pRb2/p130 and p107 expressions in CINs and SCCs.
|
16158962 |
2005 |
|
Cervical Squamous Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PRb2/p130, p107 and p53 expression in precancerous lesions and squamous cell carcinoma of the uterine cervix.
|
16158962 |
2005 |
|
Cervical intraepithelial neoplasia grade 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated Human Papillomavirus (HPV) testing and typing and pRb2/p130, p107 and p53 expressions (antibody D07) of 48 patients showing low-grade cervical intraepithelial neoplasia (LCIN, 18 cases), high-grade CIN (HCIN, 13 cases) and SCC (17 cases).
|
16158962 |
2005 |
|
Endometrial Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We examined loss of heterozygosity (LOH) at the TP53 gene in primary human endometrial carcinomas (EC), and investigated the relationship between allelic loss, p53 protein overexpression, pRb-1 pathway alterations and MIB-1 proliferative activity.
|
16293976 |
2005 |
|
precancerous lesions
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
PRb2/p130, p107 and p53 expression in precancerous lesions and squamous cell carcinoma of the uterine cervix.
|
16158962 |
2005 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Decreased expression of p107 is correlated with anaplastic transformation in papillary carcinoma of the thyroid.
|
14666683 |
2004 |
|
Carcinoma, Papillary
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Our findings suggest that p107 plays a constitutive role in the progression of papillary carcinoma and that decreased p107 expression may contribute to the transformation from follicular adenoma to follicular carcinoma and anaplastic transformation.
|
14666683 |
2004 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107.
|
14671316 |
2003 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107.
|
14671316 |
2003 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107.
|
14671316 |
2003 |
|
B-Cell Lymphomas
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We also show a detailed structure of an intragenic deletion of the p107 gene found in a human B-cell lymphoma cell line, KAL-1, which was shown to occur by homologous recombination between the two directly repeated Alu family sequences.
|
10863094 |
2000 |