|
leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Leukemia growth is inhibited by benzoxime without causing any harmful effect in rats bearing RBL-1 ×enotransplants.
|
30675257 |
2019 |
|
Childhood Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Leukemia growth is inhibited by benzoxime without causing any harmful effect in rats bearing RBL-1 ×enotransplants.
|
30675257 |
2019 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A combined deletion of the RB proteins, RB, p107 and p130 (triple-mutant; TM), prevents SATB1-induced G1 arrest, which is restored upon the reintroduction of RB into SATB1-expressing TM fibroblasts.
|
23686316 |
2013 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Animals lacking Rb and/or its family members p107 and p130 have led scientists to uncover new and exciting roles for this protein family in development as well as tumor suppression.
|
16465443 |
2006 |
|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consequently, it leads to the resistance of p107 KO mice to high-fat diet effects, prevention of liver steatosis, and improvement of the lipid profile and glucose homeostasis.
|
30383332 |
2019 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consequently, it leads to the resistance of p107 KO mice to high-fat diet effects, prevention of liver steatosis, and improvement of the lipid profile and glucose homeostasis.
|
30383332 |
2019 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Decreased expression of p107 is correlated with anaplastic transformation in papillary carcinoma of the thyroid.
|
14666683 |
2004 |
|
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of Rb2/p130 and p107 in normal human tissues and in primary lung cancer.
|
9815552 |
1997 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of Rb2/p130 and p107 in normal human tissues and in primary lung cancer.
|
9815552 |
1997 |
|
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of Rb2/p130 and p107 in normal human tissues and in primary lung cancer.
|
9815552 |
1997 |
|
Prostatic Neoplasms
|
0.020 |
GeneticVariation
|
group |
LHGDN |
Distinct roles for p107 and p130 in Rb-independent cellular senescence.
|
18418057 |
2008 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
For the first time, we tested pRb2/p130 and p107 expressions in CINs and SCCs.
|
16158962 |
2005 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further investigation into the mechanisms of MAGE-A11 function in prostate cancer demonstrated interactions with the retinoblastoma-related protein p107 and Rb tumor suppressor but no interaction with p130 of the Rb family.
|
23853093 |
2013 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further investigation into the mechanisms of MAGE-A11 function in prostate cancer demonstrated interactions with the retinoblastoma-related protein p107 and Rb tumor suppressor but no interaction with p130 of the Rb family.
|
23853093 |
2013 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further investigation into the mechanisms of MAGE-A11 function in prostate cancer demonstrated interactions with the retinoblastoma-related protein p107 and Rb tumor suppressor but no interaction with p130 of the Rb family.
|
23853093 |
2013 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, UV-induced expression from the reporter construct appears impaired in murine fibroblasts harboring inactivating mutations in the retinoblastoma (Rb) gene family members p107 and pRb but not in fibroblasts harboring such mutations in the p53 gene.
|
12870848 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Gene expression studies also revealed the capability of the NFs + Sali to upregulate tumor suppressor Rbl1 and Rbl2 as well as Caspase 3 while decreasing Wnt signaling pathway.
|
29925966 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we show, using an inducible mouse model (Rb(F/F);K14creER(TM)), that p107 exerts specific tumor suppressor functions in the absence of pRb in stratified epithelia.
|
23145321 |
2012 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we have found that acute inactivation of retinoblastoma (Rb) family proteins (Rb, p107 and p130) in mouse postmitotic neurons leads to cell death after S-phase progression.
|
28928282 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, to date, mutational data on retinoblastoma family members p107 and RB2/p130 in tumors is lacking.
|
10667591 |
2000 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In mice, inactivation of one allele of Arf cooperated with Rb and p107 loss to rapidly accelerate retinoblastoma, with frequent loss of heterozygosity (LOH) at the Arf locus.
|
22484813 |
2012 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
In this study, we characterized the cancer susceptibility of mice deficient in the expression of pRb and either of two related "pocket" proteins, p107 and p130, that are also inactivated by E7. pRb/p107-deficient mice developed head and neck cancer as frequently as do HPV-16 E7 transgenic mice.
|
22237625 |
2012 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In this study, we characterized the cancer susceptibility of mice deficient in the expression of pRb and either of two related "pocket" proteins, p107 and p130, that are also inactivated by E7. pRb/p107-deficient mice developed head and neck cancer as frequently as do HPV-16 E7 transgenic mice.
|
22237625 |
2012 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
|
25429064 |
2015 |
|
Prostatic Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Mouse xenograft studies verified miR-888 and miR-891a as pro-oncogenic factors that increased prostate tumor growth <i>in vivo</i> Further analysis validated RBL1, KLF5, SMAD4, and TIMP2 as direct miR-888 targets and that TIMP2 is also coregulated by miR-891a.
|
29330297 |
2018 |