|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
|
25429064 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our data indicates that miR-888 functions to promote prostate cancer progression and can suppress protein levels of the tumor suppressor genes RBL1 and SMAD4.
|
24200968 |
2014 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Two genes, p107 and Rb2/p130, are strictly related to RB, the most investigated tumor suppressor gene, responsible for susceptibility to retinoblastoma.
|
8872613 |
1996 |
|
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two genes, p107 and Rb2/p130, are strictly related to RB, the most investigated tumor suppressor gene, responsible for susceptibility to retinoblastoma.
|
8872613 |
1996 |
|
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Structure of the human retinoblastoma-related p107 gene and its intragenic deletion in a B-cell lymphoma cell line.
|
10863094 |
2000 |
|
Red cell distribution width determination
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.
|
28957414 |
2017 |
|
RDW - Red blood cell distribution width result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.
|
28957414 |
2017 |
|
Malignant Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
This study will provide a molecular basis for implementing comprehensive screening for p107 mutations using genomic DNAs from human malignancies.
|
10863094 |
2000 |
|
Prostatic Neoplasms
|
0.020 |
GeneticVariation
|
group |
LHGDN |
Distinct roles for p107 and p130 in Rb-independent cellular senescence.
|
18418057 |
2008 |
|
B-Cell Lymphomas
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We also show a detailed structure of an intragenic deletion of the p107 gene found in a human B-cell lymphoma cell line, KAL-1, which was shown to occur by homologous recombination between the two directly repeated Alu family sequences.
|
10863094 |
2000 |
|
Hematologic Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
These results suggest that alterations in the p107 gene are probably related to a limited subset of human hematologic malignancies.
|
9790944 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings provide formal proof for the role of loss of Rb in retinoblastoma development in the mouse and the first in vivo evidence that p107 can exert a tumor suppressor function.
|
9620848 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mutant Rb proteins isolated from tumour cells are unable to bind DRTF1/E2F (refs 11-13), and certain viral oncoproteins, such as adenovirus E1A, sequester Rb and p107 in order to free active DRTF1/E2F (refs 5, 11, 12, 14, 15).
|
8446173 |
1993 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, to date, mutational data on retinoblastoma family members p107 and RB2/p130 in tumors is lacking.
|
10667591 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The retinoblastoma (Rb) family consists of the tumor suppressor pRb/p105 and related proteins p107 and pRb2/p130.
|
10667590 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Gene expression studies also revealed the capability of the NFs + Sali to upregulate tumor suppressor Rbl1 and Rbl2 as well as Caspase 3 while decreasing Wnt signaling pathway.
|
29925966 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Two proteins, p107 and pRb2/p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the "pocket domain."
|
9815552 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
While mutations in the retinoblastoma (RB1) tumor suppressor have been reported in lung cancer, mainly in small cell lung carcinoma, the tumor suppressive role of its relatives p107 and p130 is still a matter of debate.
|
27966456 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This review portrays an updated overview about the possible tumor suppressive properties of the Rb2/p130 gene, the third member of the retinoblastoma (RB) family of genes, including RB itself and p107.
|
11406530 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
With the aim of identifying novel molecular mechanisms of hepatocyte transformation by HCV, we examined the effect of HCV core protein on the expression of the whole Retinoblastoma (RB) family of tumor and growth suppressor factors, i.e. pRb, p107 and pRb2/p130.
|
26576645 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The RB/p105 and p107 genes of the retinoblastoma family are tumor suppressor genes whose proteins are inactivated by interaction with T-antigen proteins encoded by polyomaviruses (e.g., simian virus 40 and human JC virus), which have been found to be highly tumorigenic in animals.
|
9776410 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we show, using an inducible mouse model (Rb(F/F);K14creER(TM)), that p107 exerts specific tumor suppressor functions in the absence of pRb in stratified epithelia.
|
23145321 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The members of the retinoblastoma family of pocket proteins, pRb, p107 and p130, are negative regulators of the cell cycle with tumor suppressor activity and with roles in differentiation.
|
25576924 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The retinoblastoma (Rb) family consists of the tumor suppressor Rb/p105 and related proteins p107 and Rb2/p130.
|
12769348 |
2003 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several murine retinoblastoma models have been generated by deleting the genes encoding for retinoblastoma susceptibility protein pRb and one of its family members p107 or p130.
|
27750399 |
2017 |