|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unexpectedly, removing Vhl suppressed retinoblastoma formation in murine Rb1/Rbl1-deficient retina but generated subretinal vascular growths resembling retinal angiomatous proliferation (RAP) and retinal capillary hemangioblastoma (RCH).
|
31613797 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Gene expression studies also revealed the capability of the NFs + Sali to upregulate tumor suppressor Rbl1 and Rbl2 as well as Caspase 3 while decreasing Wnt signaling pathway.
|
29925966 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
While mutations in the retinoblastoma (RB1) tumor suppressor have been reported in lung cancer, mainly in small cell lung carcinoma, the tumor suppressive role of its relatives p107 and p130 is still a matter of debate.
|
27966456 |
2017 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several murine retinoblastoma models have been generated by deleting the genes encoding for retinoblastoma susceptibility protein pRb and one of its family members p107 or p130.
|
27750399 |
2017 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
While mutations in the retinoblastoma (RB1) tumor suppressor have been reported in lung cancer, mainly in small cell lung carcinoma, the tumor suppressive role of its relatives p107 and p130 is still a matter of debate.
|
27966456 |
2017 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
UL97 phosphorylates Rb, p107 and p130, thereby inactivating all three retinoblastoma (Rb) family members.
|
28946006 |
2017 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
UL97 strongly interacts with p107 but not Rb or p130.
|
28289097 |
2017 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we have found that acute inactivation of retinoblastoma (Rb) family proteins (Rb, p107 and p130) in mouse postmitotic neurons leads to cell death after S-phase progression.
|
28928282 |
2017 |
|
Red cell distribution width determination
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.
|
28957414 |
2017 |
|
RDW - Red blood cell distribution width result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.
|
28957414 |
2017 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
|
25429064 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
With the aim of identifying novel molecular mechanisms of hepatocyte transformation by HCV, we examined the effect of HCV core protein on the expression of the whole Retinoblastoma (RB) family of tumor and growth suppressor factors, i.e. pRb, p107 and pRb2/p130.
|
26576645 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The members of the retinoblastoma family of pocket proteins, pRb, p107 and p130, are negative regulators of the cell cycle with tumor suppressor activity and with roles in differentiation.
|
25576924 |
2015 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
With the aim of identifying novel molecular mechanisms of hepatocyte transformation by HCV, we examined the effect of HCV core protein on the expression of the whole Retinoblastoma (RB) family of tumor and growth suppressor factors, i.e. pRb, p107 and pRb2/p130.
|
26576645 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our data indicates that miR-888 functions to promote prostate cancer progression and can suppress protein levels of the tumor suppressor genes RBL1 and SMAD4.
|
24200968 |
2014 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further investigation into the mechanisms of MAGE-A11 function in prostate cancer demonstrated interactions with the retinoblastoma-related protein p107 and Rb tumor suppressor but no interaction with p130 of the Rb family.
|
23853093 |
2013 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A combined deletion of the RB proteins, RB, p107 and p130 (triple-mutant; TM), prevents SATB1-induced G1 arrest, which is restored upon the reintroduction of RB into SATB1-expressing TM fibroblasts.
|
23686316 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we show, using an inducible mouse model (Rb(F/F);K14creER(TM)), that p107 exerts specific tumor suppressor functions in the absence of pRb in stratified epithelia.
|
23145321 |
2012 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In mice, inactivation of one allele of Arf cooperated with Rb and p107 loss to rapidly accelerate retinoblastoma, with frequent loss of heterozygosity (LOH) at the Arf locus.
|
22484813 |
2012 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Animals lacking Rb and/or its family members p107 and p130 have led scientists to uncover new and exciting roles for this protein family in development as well as tumor suppression.
|
16465443 |
2006 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We will focus on recent demonstrations regarding the involvement of the retinoblastoma family proteins (phosphorylated retinoblastoma (pRb), p107 and pRb2/p130) at different levels of the angiogenic process. pRb and its homologs can regulate the expression of pro- and antiangiogenic factors, such as the vascular endothelial growth factor, through an E2F-dependent mechanism.
|
16936754 |
2006 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The best-known cellular targets of the HPV-16 E7 oncoprotein are the retinoblastoma tumor suppressor protein pRB and the related pocket proteins p107 and p130.
|
16061792 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The retinoblastoma (Rb) family consists of the tumor suppressor Rb/p105 and related proteins p107 and Rb2/p130.
|
12769348 |
2003 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The retinoblastoma (Rb) family consists of the tumor suppressor Rb/p105 and related proteins p107 and Rb2/p130.
|
12769348 |
2003 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, UV-induced expression from the reporter construct appears impaired in murine fibroblasts harboring inactivating mutations in the retinoblastoma (Rb) gene family members p107 and pRb but not in fibroblasts harboring such mutations in the p53 gene.
|
12870848 |
2003 |