|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since this residue is conserved in murine RB and in the related p107 protein, we studied the activity of in vitro mutants flanking this position.
|
1334491 |
1992 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mutant Rb proteins isolated from tumour cells are unable to bind DRTF1/E2F (refs 11-13), and certain viral oncoproteins, such as adenovirus E1A, sequester Rb and p107 in order to free active DRTF1/E2F (refs 5, 11, 12, 14, 15).
|
8446173 |
1993 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transcription factor DRTF1/E2F coordinates events in the cell cycle with transcription by its cyclical interactions with important regulators of cellular proliferation like the retinoblastoma tumour-suppressor gene product (Rb) and the Rb-related protein, p107 (refs 1-8).
|
8446173 |
1993 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Two genes, p107 and Rb2/p130, are strictly related to RB, the most investigated tumor suppressor gene, responsible for susceptibility to retinoblastoma.
|
8872613 |
1996 |
|
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two genes, p107 and Rb2/p130, are strictly related to RB, the most investigated tumor suppressor gene, responsible for susceptibility to retinoblastoma.
|
8872613 |
1996 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Two proteins, p107 and pRb2/p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the "pocket domain."
|
9815552 |
1997 |
|
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of Rb2/p130 and p107 in normal human tissues and in primary lung cancer.
|
9815552 |
1997 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of Rb2/p130 and p107 in normal human tissues and in primary lung cancer.
|
9815552 |
1997 |
|
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of Rb2/p130 and p107 in normal human tissues and in primary lung cancer.
|
9815552 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings provide formal proof for the role of loss of Rb in retinoblastoma development in the mouse and the first in vivo evidence that p107 can exert a tumor suppressor function.
|
9620848 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The RB/p105 and p107 genes of the retinoblastoma family are tumor suppressor genes whose proteins are inactivated by interaction with T-antigen proteins encoded by polyomaviruses (e.g., simian virus 40 and human JC virus), which have been found to be highly tumorigenic in animals.
|
9776410 |
1998 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The RB/p105 and p107 genes of the retinoblastoma family are tumor suppressor genes whose proteins are inactivated by interaction with T-antigen proteins encoded by polyomaviruses (e.g., simian virus 40 and human JC virus), which have been found to be highly tumorigenic in animals.
|
9776410 |
1998 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The activity of E2F factors is regulated through association with the retinoblastoma tumor suppressor protein (Rb) and the other pocket proteins, p107 and p130.
|
9556498 |
1998 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings provide formal proof for the role of loss of Rb in retinoblastoma development in the mouse and the first in vivo evidence that p107 can exert a tumor suppressor function.
|
9620848 |
1998 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Particularly, an altered p107 gene in a diffuse-large B-cell lymphoma cell line, KAL-1, harbored an intragenic deletion of about 15 kbp leading to the expression of an altered p107 mRNA devoid of 819 nucleotides of the coding sequences, which predicts to encode an approximately 87-kDa protein.
|
9790944 |
1998 |
|
Hematologic Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
These results suggest that alterations in the p107 gene are probably related to a limited subset of human hematologic malignancies.
|
9790944 |
1998 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Particularly, an altered p107 gene in a diffuse-large B-cell lymphoma cell line, KAL-1, harbored an intragenic deletion of about 15 kbp leading to the expression of an altered p107 mRNA devoid of 819 nucleotides of the coding sequences, which predicts to encode an approximately 87-kDa protein.
|
9790944 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, to date, mutational data on retinoblastoma family members p107 and RB2/p130 in tumors is lacking.
|
10667591 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The retinoblastoma (Rb) family consists of the tumor suppressor pRb/p105 and related proteins p107 and pRb2/p130.
|
10667590 |
2000 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The retinoblastoma (Rb) family consists of the tumor suppressor pRb/p105 and related proteins p107 and pRb2/p130.
|
10667590 |
2000 |
|
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Structure of the human retinoblastoma-related p107 gene and its intragenic deletion in a B-cell lymphoma cell line.
|
10863094 |
2000 |
|
Malignant Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
This study will provide a molecular basis for implementing comprehensive screening for p107 mutations using genomic DNAs from human malignancies.
|
10863094 |
2000 |
|
B-Cell Lymphomas
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We also show a detailed structure of an intragenic deletion of the p107 gene found in a human B-cell lymphoma cell line, KAL-1, which was shown to occur by homologous recombination between the two directly repeated Alu family sequences.
|
10863094 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This review portrays an updated overview about the possible tumor suppressive properties of the Rb2/p130 gene, the third member of the retinoblastoma (RB) family of genes, including RB itself and p107.
|
11406530 |
2001 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review portrays an updated overview about the possible tumor suppressive properties of the Rb2/p130 gene, the third member of the retinoblastoma (RB) family of genes, including RB itself and p107.
|
11406530 |
2001 |