|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CIA was induced in DBA/1J mice.Arthritic mice were treated with bosentan (100 mg/kg) once a day, starting from the day when arthritis was clinically detectable.
|
22249931 |
2012 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice.
|
10051620 |
1999 |
|
Glaucoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gene chip microarray analysis demonstrated downregulated expression of the gamma-synuclein gene in DBA/2J mice as they developed age-associated glaucoma with concomitant with retinal ganglion cell loss.
|
31463876 |
2020 |
|
Glaucoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated whether the metabolic vulnerability observed during optic neuropathy in the DBA/2J (D2) model of glaucoma is due to dysfunctional mitochondria or impaired substrate delivery to axons, the latter based on our observation of significantly decreased glucose and monocarboxylate transporters in D2 optic nerve (ON), human ON, and mice subjected to acute glaucoma injury.
|
29760184 |
2018 |
|
Glaucoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, the impact of the Akita mutation on glaucoma was assessed using DBA/2J (D2) mice, a widely used mouse model of ocular hypertension induced glaucoma.
|
25207540 |
2014 |
|
Glaucoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we address this critical element in DBA/2J (D2) mice, an established model of chronic inherited glaucoma, using as a control the congenic substrain DBA/2J Gpnmb(+/SjJ) (D2G), which is not affected by glaucoma.
|
21246546 |
2011 |
|
Intraocular pressure disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The topical application of Ap<sub>4</sub>A when IOP is maximal (9-12 months) reduced IOP 30.6 ± 6.6% in the DBA/2J and 17.9 ± 4.0% in the C57BL/6J mice.
|
27848070 |
2017 |
|
Intraocular pressure disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These studies support the idea that age-related changes in aqueous humor outflow contribute to elevated intraocular pressure (IOP) in the DBA/2J model of pigmentary glaucoma.
|
30660703 |
2019 |
|
Intraocular pressure disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the GpnmbR150X mutation leads to increased IOP and glaucoma in DBA/2J mice, development of anterior segment and retinal defects in D2.Ppcd1 animals does not depend upon presence of the GpnmbR150X mutation.
|
28981549 |
2017 |
|
Anemia, Diamond-Blackfan
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
As RP mutations are yet to be identified in approximately 50% of DBA cases, it is likely that other yet to be identified genes involved in ribosomal biogenesis or other pathways may be responsible for DBA phenotype.
|
20655265 |
2010 |
|
Anemia, Diamond-Blackfan
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
In addition, as excessive heme could amplify ribosomal protein imbalance, prematurely lower GATA1, and impede mitosis, these data may help explain the ineffective (early termination of) erythropoiesis in Diamond Blackfan anemia and del(5q) myelodysplasia, disorders with excessive heme in colony-forming unit-erythroid/proerythroblasts, explain why these anemias are macrocytic, and show why children with GATA1 mutations have DBA-like clinical phenotypes.
|
30530752 |
2019 |
|
Anemia, Diamond-Blackfan
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
We report HSCT in 24 children with Fanconi anemia (FA, n = 12), Diamond-Blackfan anemia (DBA, n = 7), and dyskeratosis congenita (DC, n = 5) from a single HSCT center.
|
28623394 |
2017 |
|
Glaucoma, Open-Angle
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
These studies support the idea that age-related changes in aqueous humor outflow contribute to elevated intraocular pressure (IOP) in the DBA/2J model of pigmentary glaucoma.
|
30660703 |
2019 |
|
Seizures
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
Three mouse models were used: an absence seizure model based on the knockin of a human GABA(A) γ2(R43Q) mutation (DBA(R43Q)), the spike-wave discharge (SWD)-prone DBA/2J strain, and the seizure resistant C57Bl/6 strain.
|
21175610 |
2011 |
|
Seizures
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
F2 mice derived from a C3H x DBA cross that were homozygous for the C3H variant of the alpha7 RFLP were more sensitive to nicotine-induced seizures than were F2 mice that were homozygous for the DBA RFLP.
|
10942032 |
2000 |
|
Diamond-Blackfan Anemia 1
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
As RP mutations are yet to be identified in approximately 50% of DBA cases, it is likely that other yet to be identified genes involved in ribosomal biogenesis or other pathways may be responsible for DBA phenotype.
|
20655265 |
2010 |
|
Anemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In addition, as excessive heme could amplify ribosomal protein imbalance, prematurely lower GATA1, and impede mitosis, these data may help explain the ineffective (early termination of) erythropoiesis in Diamond Blackfan anemia and del(5q) myelodysplasia, disorders with excessive heme in colony-forming unit-erythroid/proerythroblasts, explain why these anemias are macrocytic, and show why children with GATA1 mutations have DBA-like clinical phenotypes.
|
30530752 |
2019 |
|
Anemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Mutations in GATA-1 are associated with acute megakaryoblastic leukemia (AMKL), congenital erythroid hypoplasia (Diamond-Blackfan anemia; DBA), and X-linked anemia and/or thrombocytopenia.
|
28566565 |
2017 |
|
Arteriosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We conclude that genetic variants unique to DBA/2J at Aath4 confer susceptibility to atherosclerosis at the aortic arch.
|
28837567 |
2017 |
|
Atherosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We conclude that genetic variants unique to DBA/2J at Aath4 confer susceptibility to atherosclerosis at the aortic arch.
|
28837567 |
2017 |
|
Kidney Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
To study this, we developed a transgenic mouse model expressing CCR2 specifically in podocytes (Tg[NPHS2-Ccr2]) on a nephropathy-prone (DBA/2J) and CCR2-deficient (Ccr2<sup>-/-</sup>) background with heterozygous Ccr2<sup>+/-</sup> littermate controls.Diabetes was induced by streptozotocin.
|
27914709 |
2017 |
|
melanoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To improve its therapeutic efficacy and overcome drug resistance in advanced melanomas, we synthesized Tris DBA-Pd hyaluronic acid nanoparticles (Tris DBA-Pd HANP) and evaluated them against in vivo xenografts of LM36R, an aggressive BRAF mutant human melanoma resistant to BRAF inhibitors.
|
30824801 |
2019 |
|
melanoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Finally, Tris DBA palladium was orally effective against GNAQ mutant melanoma <i>in vivo</i>.
|
31320995 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Ectopic expression of Arid4b promoted primary tumor growth in vivo as well as increased migration and invasion in vitro, and the phenotype was associated with polymorphisms identified between the AKR/J and DBA/2J alleles as predicted by our genetic analyses.
|
22693453 |
2012 |
|
Anemia, Sickle Cell
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among 175 patients included, the majority had sickle cell disease (SCD; 52%), followed by aplastic anemia (AA; 17.7%), myelodysplastic syndrome (MDS; 8.6%), Diamond-Blackfan anemia (DBA; 4%), pure red cell aplasia (1.1%), and others (16.6%).
|
29663858 |
2018 |