|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, NSC23766 alleviated the process of collagen-induced arthritis of DBA mice in vivo, including the reduced hind paw thickness and ankle stiffness, the reduction of arthritic scores and incidence of arthritis.
|
30880553 |
2020 |
|
Glaucoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gene chip microarray analysis demonstrated downregulated expression of the gamma-synuclein gene in DBA/2J mice as they developed age-associated glaucoma with concomitant with retinal ganglion cell loss.
|
31463876 |
2020 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Exposure of leukocytes from type II collagen-immunized DBA/1 mice to ibudilast in vitro attenuated their ability to adoptively transfer arthritis to DBA/1J-Prkdc<sup>SCID</sup> mice, providing evidence of an immunomodulatory effect.
|
30474934 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alpha-mangostin: Anti-inflammatory and antioxidant effects on established collagen-induced arthritis in DBA/1J mice.
|
30557668 |
2019 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using a panel of immunohistochemical and immunofluorescence analyses in a CIA model established in 18 DBA/1J mice, we demonstrated that IL-35 promotes synoviocyte apoptosis and alternative activation of macrophages to alleviate arthritis in vivo.
|
30834683 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A mouse model of DBA/1JJmsSlc collagen-induced arthritis was treated with Th2 or Th17 cell inhibitor, and transepidermal water loss (TEWL) and the expression of markers associated with allergic reaction and inflammation were evaluated.
|
30828078 |
2019 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previously, we performed transcriptional profiling in DBA/2J (D2) mice, a widely used mouse model relevant to glaucoma.
|
31369031 |
2019 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously demonstrated that monocyte-like cells enter the optic nerve head in an ocular hypertensive mouse model of glaucoma (DBA/2 J), but their roles, if any, in mediating axon damage remain unclear.
|
30670050 |
2019 |
|
Intraocular pressure disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These studies support the idea that age-related changes in aqueous humor outflow contribute to elevated intraocular pressure (IOP) in the DBA/2J model of pigmentary glaucoma.
|
30660703 |
2019 |
|
Intraocular pressure disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Meox2 haploinsufficiency did not affect the characteristic diseases of the iris or IOP elevation seen in DBA/2J mice but did cause a significant increase in the numbers of eyes with axon damage compared to controls.
|
31369031 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Exogenous GH administration in arthritic DBA/1J mice reduced the severity of established CIA as well as the inflammatory environment, which also shows a GH effect on arthritis progression.
|
29887869 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice with DBA/1JJmsSlc collagen-induced arthritis were treated with inhibitors or neutralizing antibodies.
|
29698950 |
2018 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results showed that LCA significantly suppressed arthritis via the activation of SQSTM1 (p62)/nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling in the collagen-induced arthritis (CIA) model of DBA mice.
|
29233793 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBA/1JJmsSlc control mice (n = 5) and DBA/1JJmsSlc collagen-induced arthritis mouse model (arthritis mice; n = 5) were used.
|
28573874 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the improvement of astilbin and low-dose MTX combination on collagen-induced arthritis in DBA/1J mice.
|
29410374 |
2018 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBA/2J mice that develop glaucoma with age were also acquired.
|
29294337 |
2018 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that neurophysiological deficits in the DBA/2J may be due to defects in intact axons and targeting node pathology may be a promising intervention for some types of glaucoma.
|
30149050 |
2018 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show in DBA/2J mice with spontaneous IOP elevation and glaucoma that the lifespan of functional RGCs can be extended by preconditioning RGCs with retrobulbar lidocaine in one eye at four months of age that temporary blocks RGC axonal transport.
|
29342845 |
2018 |
|
Glaucoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated whether the metabolic vulnerability observed during optic neuropathy in the DBA/2J (D2) model of glaucoma is due to dysfunctional mitochondria or impaired substrate delivery to axons, the latter based on our observation of significantly decreased glucose and monocarboxylate transporters in D2 optic nerve (ON), human ON, and mice subjected to acute glaucoma injury.
|
29760184 |
2018 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine if bone marrow-derived stem cell (BMSC) small extracellular vesicles (sEV) promote retinal ganglion cell (RGC) neuroprotection in the genetic DBA/2J mouse model of glaucoma for 12 months.
|
30452601 |
2018 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using DBA/2J mice as a model of glaucoma and DBA/2J-Gpnmb+ as a nonglaucomatous control, the relationship between MT disruption and morphology was quantitatively examined as a function of age and sex in the fresh retinal wholemounts.
|
30383181 |
2018 |
|
Intraocular pressure disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Failure of AAT to SC of DBA/2J mice during development of pigmentary glaucoma does not follow closely changes in IOP and eye morphology.
|
29283693 |
2018 |
|
Intraocular pressure disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show in DBA/2J mice with spontaneous IOP elevation and glaucoma that the lifespan of functional RGCs can be extended by preconditioning RGCs with retrobulbar lidocaine in one eye at four months of age that temporary blocks RGC axonal transport.
|
29342845 |
2018 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the GpnmbR150X mutation leads to increased IOP and glaucoma in DBA/2J mice, development of anterior segment and retinal defects in D2.Ppcd1 animals does not depend upon presence of the GpnmbR150X mutation.
|
28981549 |
2017 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study examines the differential expression of <i>Sox11</i> and <i>Bdnf</i> mRNA isoforms in the PNS and CNS using three experimental paradigms at different time points: (i) the acutely injured CNS (retina after optic nerve crush) and PNS (dorsal root ganglion after sciatic nerve crush), (ii) a CNS regeneration model (retina after optic nerve crush and induced regeneration); and (iii) the retina during a chronic form of central neurodegeneration (the DBA/2J glaucoma model).
|
29209164 |
2017 |