|
Absence Epilepsy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Three mouse models were used: an absence seizure model based on the knockin of a human GABA(A) γ2(R43Q) mutation (DBA(R43Q)), the spike-wave discharge (SWD)-prone DBA/2J strain, and the seizure resistant C57Bl/6 strain.
|
21175610 |
2011 |
|
Absence Seizures
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Three mouse models were used: an absence seizure model based on the knockin of a human GABA(A) γ2(R43Q) mutation (DBA(R43Q)), the spike-wave discharge (SWD)-prone DBA/2J strain, and the seizure resistant C57Bl/6 strain.
|
21175610 |
2011 |
|
Acute Megakaryocytic Leukemias
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations in GATA-1 are associated with acute megakaryoblastic leukemia (AMKL), congenital erythroid hypoplasia (Diamond-Blackfan anemia; DBA), and X-linked anemia and/or thrombocytopenia.
|
28566565 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There were 18 lectins (e.g., AAL, Jacalin, GSL-I and DBA) to give significantly alterations of serum glycopatterns in lung adenocarcinoma compared with control group.
|
31168300 |
2019 |
|
AICARDI-GOUTIERES SYNDROME
|
0.010 |
Biomarker
|
disease |
BEFREE |
DBA mice exhibit seizure-induced respiratory arrest (S-IRA), leading to cardiac arrest and subsequent sudden death after generalized audiogenic seizures (AGSs).
|
26272185 |
2017 |
|
Amaurosis congenita of Leber, type 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that LCA significantly suppressed arthritis via the activation of SQSTM1 (p62)/nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling in the collagen-induced arthritis (CIA) model of DBA mice.
|
29233793 |
2018 |
|
Anemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In addition, as excessive heme could amplify ribosomal protein imbalance, prematurely lower GATA1, and impede mitosis, these data may help explain the ineffective (early termination of) erythropoiesis in Diamond Blackfan anemia and del(5q) myelodysplasia, disorders with excessive heme in colony-forming unit-erythroid/proerythroblasts, explain why these anemias are macrocytic, and show why children with GATA1 mutations have DBA-like clinical phenotypes.
|
30530752 |
2019 |
|
Anemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Mutations in GATA-1 are associated with acute megakaryoblastic leukemia (AMKL), congenital erythroid hypoplasia (Diamond-Blackfan anemia; DBA), and X-linked anemia and/or thrombocytopenia.
|
28566565 |
2017 |
|
Anemia, Diamond-Blackfan
|
0.050 |
Biomarker
|
disease |
BEFREE |
Hazard ratios for these lectins were (+1 SD for the glycan index) as follows: SNA (recognizing glycan Siaα2-6Gal/GalNAc), 1.42 (95% CI 1.14-1.76); RCA120 (Galβ4GlcNAc), 1.28 (1.01-1.64); DBA (GalNAcα3GalNAc), 0.80 (0.64-0.997); ABA (Galβ3GalNAc), 1.29 (1.02-1.64); Jacalin (Galβ3GalNAc), 1.30 (1.02-1.67); and ACA (Galβ3GalNAc), 1.32 (1.04-1.67).
|
29930140 |
2018 |
|
Anemia, Diamond-Blackfan
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
As RP mutations are yet to be identified in approximately 50% of DBA cases, it is likely that other yet to be identified genes involved in ribosomal biogenesis or other pathways may be responsible for DBA phenotype.
|
20655265 |
2010 |
|
Anemia, Diamond-Blackfan
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
In addition, as excessive heme could amplify ribosomal protein imbalance, prematurely lower GATA1, and impede mitosis, these data may help explain the ineffective (early termination of) erythropoiesis in Diamond Blackfan anemia and del(5q) myelodysplasia, disorders with excessive heme in colony-forming unit-erythroid/proerythroblasts, explain why these anemias are macrocytic, and show why children with GATA1 mutations have DBA-like clinical phenotypes.
|
30530752 |
2019 |
|
Anemia, Diamond-Blackfan
|
0.050 |
Biomarker
|
disease |
BEFREE |
The present analyses demonstrate that Rpl11-deficient zebrafish may serve as a model of DBA and may provide insights into the pathogenesis of mutant RPL11-mediated human DBA disease.
|
24341334 |
2013 |
|
Anemia, Diamond-Blackfan
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
We report HSCT in 24 children with Fanconi anemia (FA, n = 12), Diamond-Blackfan anemia (DBA, n = 7), and dyskeratosis congenita (DC, n = 5) from a single HSCT center.
|
28623394 |
2017 |
|
Anemia, Sickle Cell
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among 175 patients included, the majority had sickle cell disease (SCD; 52%), followed by aplastic anemia (AA; 17.7%), myelodysplastic syndrome (MDS; 8.6%), Diamond-Blackfan anemia (DBA; 4%), pure red cell aplasia (1.1%), and others (16.6%).
|
29663858 |
2018 |
|
Ankle stiff
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, NSC23766 alleviated the process of collagen-induced arthritis of DBA mice in vivo, including the reduced hind paw thickness and ankle stiffness, the reduction of arthritic scores and incidence of arthritis.
|
30880553 |
2020 |
|
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
To identify biological pathways mediating stress-related anxiety and resilience to it, we used the chronic social defeat stress (CSDS) paradigm in male mice of two inbred strains, C57BL/6NCrl (B6) and DBA/2NCrl (D2), that differ in their susceptibility to stress.
|
31557158 |
2019 |
|
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
To identify biological pathways mediating stress-related anxiety and resilience to it, we used the chronic social defeat stress (CSDS) paradigm in male mice of two inbred strains, C57BL/6NCrl (B6) and DBA/2NCrl (D2), that differ in their susceptibility to stress.
|
31557158 |
2019 |
|
Aplastic Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
An immune-mediated AA mouse model was established in BALB/c mice by exposing to 5.0 Gy total body irradiation at 1.0 Gy/min, and injecting with lymphocytes from DBA mice.
|
31802424 |
2019 |
|
Aqueous Humor Disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
The comparative profiles of normotensive and hypertensive DBA/2J mouse AH showed several species of sphingomyelin, sphingoid base, sphingoid base-1-phosphate (S1P) and ceramides common between them.
|
25014247 |
2014 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Mouse strains that were resistant to atherosclerosis (FVB/NJ, DBA/2J, BALB/c) exhibited a protective extracellular vascular ecto-enzyme pattern directed toward the production of anti-inflammatory and anti-atherosclerotic adenosine.
|
30587087 |
2018 |
|
Arteriosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We conclude that genetic variants unique to DBA/2J at Aath4 confer susceptibility to atherosclerosis at the aortic arch.
|
28837567 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Exogenous GH administration in arthritic DBA/1J mice reduced the severity of established CIA as well as the inflammatory environment, which also shows a GH effect on arthritis progression.
|
29887869 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice with DBA/1JJmsSlc collagen-induced arthritis were treated with inhibitors or neutralizing antibodies.
|
29698950 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBA/1J mice with CIA that received IL-17-/- donor bone marrow showed potently inhibited development and severity of clinical arthritis as compared with CIA mice that received WT bone marrow.
|
23114425 |
2012 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Exposure of leukocytes from type II collagen-immunized DBA/1 mice to ibudilast in vitro attenuated their ability to adoptively transfer arthritis to DBA/1J-Prkdc<sup>SCID</sup> mice, providing evidence of an immunomodulatory effect.
|
30474934 |
2019 |