|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Exogenous GH administration in arthritic DBA/1J mice reduced the severity of established CIA as well as the inflammatory environment, which also shows a GH effect on arthritis progression.
|
29887869 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice with DBA/1JJmsSlc collagen-induced arthritis were treated with inhibitors or neutralizing antibodies.
|
29698950 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBA/1J mice with CIA that received IL-17-/- donor bone marrow showed potently inhibited development and severity of clinical arthritis as compared with CIA mice that received WT bone marrow.
|
23114425 |
2012 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Exposure of leukocytes from type II collagen-immunized DBA/1 mice to ibudilast in vitro attenuated their ability to adoptively transfer arthritis to DBA/1J-Prkdc<sup>SCID</sup> mice, providing evidence of an immunomodulatory effect.
|
30474934 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, NSC23766 alleviated the process of collagen-induced arthritis of DBA mice in vivo, including the reduced hind paw thickness and ankle stiffness, the reduction of arthritic scores and incidence of arthritis.
|
30880553 |
2020 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To find an "unlimited" source of antigenic material (aggrecan) for arthritis induction in BALB/c mice; to analyze the specificities of immune reactions to aggrecan and type II collagen in 2 arthritis-susceptible murine strains, BALB/c mice for proteoglycan (aggrecan)-induced arthritis and DBA/1j mice for collagen-induced arthritis; to compare the histopathologic features of arthritis induced by purified aggrecans or total extracts of osteoarthritic (OA) cartilage; and to determine arthritis susceptibility in various BALB/c colonies.
|
9627010 |
1998 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alpha-mangostin: Anti-inflammatory and antioxidant effects on established collagen-induced arthritis in DBA/1J mice.
|
30557668 |
2019 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using a panel of immunohistochemical and immunofluorescence analyses in a CIA model established in 18 DBA/1J mice, we demonstrated that IL-35 promotes synoviocyte apoptosis and alternative activation of macrophages to alleviate arthritis in vivo.
|
30834683 |
2019 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CIA was induced in DBA/1J mice.Arthritic mice were treated with bosentan (100 mg/kg) once a day, starting from the day when arthritis was clinically detectable.
|
22249931 |
2012 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast to the situation in humans, lpxL1 LPS has agonistic activity for cytokine production in peritoneal macrophages of DBA mice, and exacerbated arthritis in murine collagen induced arthritis model.
|
21088052 |
2011 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results showed that LCA significantly suppressed arthritis via the activation of SQSTM1 (p62)/nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling in the collagen-induced arthritis (CIA) model of DBA mice.
|
29233793 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBA/1JJmsSlc control mice (n = 5) and DBA/1JJmsSlc collagen-induced arthritis mouse model (arthritis mice; n = 5) were used.
|
28573874 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the improvement of astilbin and low-dose MTX combination on collagen-induced arthritis in DBA/1J mice.
|
29410374 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A mouse model of DBA/1JJmsSlc collagen-induced arthritis was treated with Th2 or Th17 cell inhibitor, and transepidermal water loss (TEWL) and the expression of markers associated with allergic reaction and inflammation were evaluated.
|
30828078 |
2019 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice.
|
10051620 |
1999 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To induce arthritis in mice, rYKL-39 (1, 10 or 50 g in Freund's incomplete adjuvant) was injected into the right footpad of mice from four different strains (BALB/c, DBA/1J, C57BL/6 and ICR).
|
12102470 |
2003 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis.
|
18178865 |
2008 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBA/2J mice that develop glaucoma with age were also acquired.
|
29294337 |
2018 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previously, we performed transcriptional profiling in DBA/2J (D2) mice, a widely used mouse model relevant to glaucoma.
|
31369031 |
2019 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that neurophysiological deficits in the DBA/2J may be due to defects in intact axons and targeting node pathology may be a promising intervention for some types of glaucoma.
|
30149050 |
2018 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identification of a mutation in the IL-20RB gene in a glaucoma pedigree and changes in expression levels of IL-20 family members in the DBA/2J mouse suggest that disruption of normal IL-20 signaling in the eye may contribute to degenerative processes associated with glaucoma.
|
26903709 |
2016 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the GpnmbR150X mutation leads to increased IOP and glaucoma in DBA/2J mice, development of anterior segment and retinal defects in D2.Ppcd1 animals does not depend upon presence of the GpnmbR150X mutation.
|
28981549 |
2017 |
|
Glaucoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gene chip microarray analysis demonstrated downregulated expression of the gamma-synuclein gene in DBA/2J mice as they developed age-associated glaucoma with concomitant with retinal ganglion cell loss.
|
31463876 |
2020 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show in DBA/2J mice with spontaneous IOP elevation and glaucoma that the lifespan of functional RGCs can be extended by preconditioning RGCs with retrobulbar lidocaine in one eye at four months of age that temporary blocks RGC axonal transport.
|
29342845 |
2018 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBA/2J (D2) mice develop an age-related form of glaucoma.
|
16827931 |
2006 |