|
beta Thalassemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
beta thalassemia (beta thal) in DBA/2J mice is a consequence of the spontaneous and complete deletion of the beta major globin gene.
|
8562946 |
1996 |
|
beta^+^ Thalassemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
beta thalassemia (beta thal) in DBA/2J mice is a consequence of the spontaneous and complete deletion of the beta major globin gene.
|
8562946 |
1996 |
|
Congenital hypoplastic anemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A 7 year old girl is described with congenital hypoplastic anaemia (Diamond-Blackfan anaemia, DBA) and an apparently balanced reciprocal translocation, 46,XX,t(X;19)(p21;q13).
|
9321770 |
1997 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To find an "unlimited" source of antigenic material (aggrecan) for arthritis induction in BALB/c mice; to analyze the specificities of immune reactions to aggrecan and type II collagen in 2 arthritis-susceptible murine strains, BALB/c mice for proteoglycan (aggrecan)-induced arthritis and DBA/1j mice for collagen-induced arthritis; to compare the histopathologic features of arthritis induced by purified aggrecans or total extracts of osteoarthritic (OA) cartilage; and to determine arthritis susceptibility in various BALB/c colonies.
|
9627010 |
1998 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice.
|
10051620 |
1999 |
|
Catalepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Detection and mapping of quantitative trait loci for haloperidol-induced catalepsy in a C57BL/6J x DBA/2J F2 intercross.
|
10765558 |
1999 |
|
Seizures
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
This article describes the identification of SLC19A3, a gene encoding a novel solute transporter, and establishes murine SLC19A3 as a candidate gene for seizures in the DBA/2J mouse.
|
11136550 |
2000 |
|
Seizures
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
F2 mice derived from a C3H x DBA cross that were homozygous for the C3H variant of the alpha7 RFLP were more sensitive to nicotine-induced seizures than were F2 mice that were homozygous for the DBA RFLP.
|
10942032 |
2000 |
|
Hepatitis B
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
With respect to virernia, in two subjects with low titre of HBV DNA (< 100 MEq/ml), no variation was found in the YMDD motif, whereas in seven patients with high titre of HBV DBA (> 300 MEq/ml), five (71%) had variations in the YMDD motif.
|
11776105 |
2000 |
|
Ductal plate malformation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DBA/2J (D2), CD-1, BALB/c and Mus mus castaneus (CAST), express the DPM.
|
10749984 |
2000 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Despite the phenotypic similarity between the glaucoma in the DBA/2J mouse and human pigmentary glaucoma, the results of this study suggest that DNA sequence variants in the human TYRP1 gene are not associated with inherited pigmentary glaucoma in humans.
|
12011806 |
2002 |
|
Glaucoma, Open-Angle
|
0.040 |
Biomarker
|
disease |
BEFREE |
DBA/2J (D2) mice develop a form of pigmentary glaucoma involving iris pigment dispersion (IPD) and iris stromal atrophy (ISA).
|
11743578 |
2002 |
|
Hyperthyroidism
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast, none of female CBA/J (H-2(k)), DBA/1J (H-2(q)), or SJL/J (H-2(s)) mice developed Graves' hyperthyroidism or anti-TSHR autoantibodies except SJL/J, which showed strong TBII activities.
|
11884447 |
2002 |
|
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These tumors occur at much younger ages than in the general population, in patients who do not appear to have the usual risk factors, and have patterns that are characteristic to the syndrome, such as head and neck and gynecologic cancers in FA and DC, and osteogenic sarcomas in DBA.
|
12430621 |
2002 |
|
Atrophic iris
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Recently, a form of glaucoma associated with pigment dispersion and iris atrophy was identified in the DBA/2J mouse.
|
12011806 |
2002 |
|
Trichohepatoenteric Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
These tumors occur at much younger ages than in the general population, in patients who do not appear to have the usual risk factors, and have patterns that are characteristic to the syndrome, such as head and neck and gynecologic cancers in FA and DC, and osteogenic sarcomas in DBA.
|
12430621 |
2002 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To induce arthritis in mice, rYKL-39 (1, 10 or 50 g in Freund's incomplete adjuvant) was injected into the right footpad of mice from four different strains (BALB/c, DBA/1J, C57BL/6 and ICR).
|
12102470 |
2003 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
DBA/2J animals were 3-fold more sensitive to AFB(1)-induced HCC and significantly more sensitive to AFB(1) acute toxicity than were C57BL/6J animals.
|
12907637 |
2003 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
To evaluate the genetic susceptibility to metabolic disorders induced by high fructose diet, we investigated the metabolic characteristics in 10 strains of inbred mice and found that they were separated into CBA and DBA groups according to the response to high fructose diet.
|
15123654 |
2004 |
|
Glaucoma, Open-Angle
|
0.040 |
Biomarker
|
disease |
BEFREE |
We also observed that activated NF-kappaB and phosphorylated MAPK are increased in the iris/ciliary body of DBA/2J mice, suggesting that both signaling pathways may be involved in IL-18 mediated pathogenesis of pigmentary glaucoma in the eyes of DBA/2J mice.
|
15985430 |
2005 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBA/2J (D2) mice develop an age-related form of glaucoma.
|
16827931 |
2006 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis.
|
18178865 |
2008 |
|
Influenza
|
0.040 |
Biomarker
|
disease |
BEFREE |
To model host factors in the context of influenza virus infection, we determined the lethal dose of a highly pathogenic H5N1 virus (A/Hong Kong/213/03) in C57BL/6J and DBA/2J mice and identified genetic elements associated with survival after infection.
|
19706712 |
2009 |
|
Anemia, Diamond-Blackfan
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
As RP mutations are yet to be identified in approximately 50% of DBA cases, it is likely that other yet to be identified genes involved in ribosomal biogenesis or other pathways may be responsible for DBA phenotype.
|
20655265 |
2010 |
|
Diamond-Blackfan Anemia 1
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
As RP mutations are yet to be identified in approximately 50% of DBA cases, it is likely that other yet to be identified genes involved in ribosomal biogenesis or other pathways may be responsible for DBA phenotype.
|
20655265 |
2010 |