|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactions were detected between ADRA2A C-1291G and ADRB2 Gln27-->Glu variants for obesity in African Americans and between ADRA2A C-1291G SNP and ADBR1 haplotype for obesity in whites.
|
17512307 |
2007 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Glu27Gln polymorphism had no significant effect on asthma exacerbations in any treatment group.
|
16772309 |
2006 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we examined the variability of definitions of endpoints and analyses reported across studies addressing the association of the Arg16Gly and/or Gln27Glu polymorphisms of the beta2-adrenergic receptor gene with clinical response to beta2-agonist therapy in asthma.
|
17001289 |
2006 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between polymorphisms in the beta(2)-adrenergic receptor gene (ADRB2) (-47C/T, Arg16/Gly, Gln27/Glu) and stage-2 hypertension in northern Han Chinese.
|
15638826 |
2005 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common Arg16Gly and Gln27Glu polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) have been associated with hypertension and coronary disease.
|
15797659 |
2005 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Results for Gln/Glu27 in adults seem to indicate that heterozygotes are at decreased risk of asthma than either homozygote (odds ratio = 0.73, 95% CI: 0.62, 0.87), although the studies are heterogeneous; in children, the Glu/Glu genotype has a decreased risk of asthma (odds ratio = 0.60, 95% CI: 0.35, 0.99) compared with the other genotypes.
|
15987731 |
2005 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several case-control studies have explored the possible association between polymorphism in the beta2 adrenoreceptor gene (beta2AR), hypertension, and obesity--the focus being in particular on the Arg16Gly and Gln27Glu substitutions, which appear to modify the extracellular part of the beta2AR with possible functional modification.
|
15323067 |
2004 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism.
|
12888635 |
2003 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
As there is a high prevalence of obesity in Tonga, we aimed to determine the distribution of the beta2 adrenoceptor gene Gln(27)Glu polymorphism and to assess its relevance to obesity and to Type II diabetes, known to be prevalent in that population.
|
12605574 |
2003 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, for the polymorphic sites of BAR-2 (Arg16Gly and Gln27Glu) a significant effect on obesity risk was seen.
|
12395215 |
2002 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results provide evidence about a possible impact of the Gln27Glu polymorphism in the ADRB2 gene concerning a better response to exercise in obese Gln27 female subjects, in which basal insulinemia may play a role.
|
12435085 |
2002 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Four ADRB2 gene polymorphisms C19R (T-47C), T-20C, G16R (G+46A), Q27E (C+79G) were investigated in two studies: PEGASE, a study of moderate to severe hypertension (707 cases) conducted in France, and ECTIM, a case-control study of MI (1178 cases, 1187 controls) conducted in France, Northern Ireland and Scotland.
|
11821707 |
2002 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether polymorphisms in the beta(2)-adrenergic receptor gene (5'LC-Arg19Cys, Arg16Gly, Gln27Glu) are associated with hypertension in patients with or without type 2 diabetes and with the blood pressure levels in normotensive sib pairs.
|
11358945 |
2001 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies have suggested that two polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) gene at codons 16 (arginine to glycine) and 27 (glutamine to glutamate) affect an individual's airway responsiveness, or response to acute or chronic beta(2)-agonist therapy but are not risk factors for asthma.
|
11371409 |
2001 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, the Gln27Glu beta2-ADR variant is excluded in HT, but might influence body weight.
|
11775127 |
2001 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Even in Japanese-Americans, who have a more westernized life style than Japanese, the association of the beta(2)-AR gene (Gln27Glu) variant with the parameters of obesity, insulin resistance, and serum lipid level has yet to be clarified.
|
11288039 |
2001 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no evidence of association between the C-47T and Glu27Gln polymorphisms and hypertension in this population.
|
11775126 |
2001 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Neither the Arg16Gly nor Gln27Glu polymorphisms showed evidence of linkage to qualitative measures of asthma and bronchial hyperresponsiveness (BHR) (p > 0.10) or to quantitative measures of serum IgE and airway reactivity (p > 0.10).
|
10934093 |
2000 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the Gln27Glu and Arg16Gly polymorphisms of the beta2AR gene are not a major contributing factor to obesity in Japanese men.
|
11016907 |
2000 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Asthmatics heterozygous for Gln/Glu27 had significantly later asthma onsets than those homozygous for Gln27.
|
10524541 |
1999 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females.
|
10205587 |
1999 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms at amino acid positions 16 (arginine to glycine) and 27 (glutamine to glutamic acid) of the beta2-adrenoreceptor (B2AR) gene are known to be functionally relevant and have been associated with more severe forms of asthma, nocturnal asthma and decreased airway responsiveness in asthmatic subjects.
|
10469027 |
1999 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, we have found that in Japanese men the Gln27Glu beta2AR variant is associated with obesity due to subcutaneous fat accumulation.
|
10222249 |
1999 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Gln27Glu polymorphism was markedly associated with obesity with a relative risk for obesity of approximately 7 and an odds ratio of approximately 10.
|
9399946 |
1997 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied beta 2-adrenoceptor genotype for the Gln/Glu 27 polymorphism and airway reactivity in 65 patients with mild to moderate asthma.
|
7739309 |
1995 |