|
rs1130409
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We investigated the association of polymorphisms in the DNA repair genes XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys with endometriosis risk.
|
20391347 |
2010 |
|
rs1130409
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The APEX1 Asp(148)Glu genotype correlates well with its mRNA and protein expression among endometriosis patients and may not serve as a sensitive marker for prediction of endometriosis risk in Taiwan.
|
25422360 |
2015 |
|
rs74781061
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
New variants near RHOJ and C2, HLA-DRA region and susceptibility to endometriosis in the Polish population-The genome-wide association study.
|
28881265 |
2017 |
|
rs777161444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that the polymorphisms of AhR Arg554Lys and ARNT Val189Val are not associated with endometriosis, while the AhRR Pro185Ala polymorphism may be associated with endometriosis risk.
|
26101050 |
2015 |
|
rs4837864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs within the 22 CNVRs show significant genotypic association with endometriosis after adjusting for multiple testing; rs758316 in DPP6 on 7q36.2 (P = 0.0045) and rs4837864 in ASTN2 on 9q33.1 (P = 0.0002).
|
25083881 |
2014 |
|
rs498679
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant difference was observed in genotypic or allelic frequencies between control and endometriosis groups for rs498679 (TLR4 gene), rs1799964 (TNF-α gene), rs3024496 (IL-10 gene), neither when comparing endometriosis subgroups (I-II versus III-IV).
|
28470452 |
2017 |
|
rs1801516
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five variants were previously reported to confer risk of various malignant or benign tumors (rs78378222 in TP53, rs10069690 in TERT, rs1800057 and rs1801516 in ATM, and rs7907606 at OBFC1) and four signals are located at established risk loci for hormone-related traits (endometriosis and breast cancer) at 1q36.12 (CDC42/WNT4), 2p25.1 (GREB1), 20p12.3 (MCM8), and 6q26.2 (SYNE1/ESR1).
|
30194396 |
2018 |
|
rs6265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RESULTS There was no association between the BDNF Val66Met polymorphism and overall endometriosis (P> 0.05), whereas higher genotype and allele frequencies of the BDNF(Met) polymorphism were found in the Stage III-IV endometriosis (both P< 0.01) and endometriosis-related infertile patients (both P< 0.05).
|
22447624 |
2012 |
|
rs759834365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RESULTS There was no association between the BDNF Val66Met polymorphism and overall endometriosis (P> 0.05), whereas higher genotype and allele frequencies of the BDNF(Met) polymorphism were found in the Stage III-IV endometriosis (both P< 0.01) and endometriosis-related infertile patients (both P< 0.05).
|
22447624 |
2012 |
|
rs3820445
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
New variants near RHOJ and C2, HLA-DRA region and susceptibility to endometriosis in the Polish population-The genome-wide association study.
|
28881265 |
2017 |
|
rs625879
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied 16 SNPs in 12 folate and choline metabolism genes, including BHMT (rs7356530 and rs3733890), BHMT2 (rs625879), CBS (844ins68), CHDH (rs893363 and rs2289205), CHKA (rs7928739), MTHFD1 (rs2236225), MTHFR (rs1801133), MTR (rs1805087), MTRR (rs1801394), PCYT1A (rs712012 and rs7639752), PEMT (rs4244593 and rs4646406) and TCN (rs1801198) in one hundred and sixty-three infertile women with minimal endometriosis and one hundred and fifty fertile women.
|
21429654 |
2011 |
|
rs3733890
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied 16 SNPs in 12 folate and choline metabolism genes, including BHMT (rs7356530 and rs3733890), BHMT2 (rs625879), CBS (844ins68), CHDH (rs893363 and rs2289205), CHKA (rs7928739), MTHFD1 (rs2236225), MTHFR (rs1801133), MTR (rs1805087), MTRR (rs1801394), PCYT1A (rs712012 and rs7639752), PEMT (rs4244593 and rs4646406) and TCN (rs1801198) in one hundred and sixty-three infertile women with minimal endometriosis and one hundred and fifty fertile women.
|
21429654 |
2011 |
|
rs71361504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRCA1 rs71361504 SNP may modify the endometriosis risk in Indian women.
|
25380576 |
2015 |
|
rs144824657
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
New variants near RHOJ and C2, HLA-DRA region and susceptibility to endometriosis in the Polish population-The genome-wide association study.
|
28881265 |
2017 |
|
rs644045
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We have also identified significant association with endometriosis of 18 SNPs localised on chromosome 6 in position range 31883957 - 32681631 (C2 and HLA-DRA genes region) with the lowest observed p value for rs644045 in C2 gene (p=2.04×10<sup>-8</sup>, OR=1.955, 95% CI=1.541-2.480).
|
28881265 |
2017 |
|
rs644045
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
We have also identified significant association with endometriosis of 18 SNPs localised on chromosome 6 in position range 31883957 - 32681631 (C2 and HLA-DRA genes region) with the lowest observed p value for rs644045 in C2 gene (p=2.04×10<sup>-8</sup>, OR=1.955, 95% CI=1.541-2.480).
|
28881265 |
2017 |
|
rs11085835
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
New variants near RHOJ and C2, HLA-DRA region and susceptibility to endometriosis in the Polish population-The genome-wide association study.
|
28881265 |
2017 |
|
rs893363
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied 16 SNPs in 12 folate and choline metabolism genes, including BHMT (rs7356530 and rs3733890), BHMT2 (rs625879), CBS (844ins68), CHDH (rs893363 and rs2289205), CHKA (rs7928739), MTHFD1 (rs2236225), MTHFR (rs1801133), MTR (rs1805087), MTRR (rs1801394), PCYT1A (rs712012 and rs7639752), PEMT (rs4244593 and rs4646406) and TCN (rs1801198) in one hundred and sixty-three infertile women with minimal endometriosis and one hundred and fifty fertile women.
|
21429654 |
2011 |
|
rs116250606
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
New variants near RHOJ and C2, HLA-DRA region and susceptibility to endometriosis in the Polish population-The genome-wide association study.
|
28881265 |
2017 |
|
rs116175374
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis.
|
28333195 |
2017 |
|
rs17387019
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found no evidence for an association between the highly correlated SNP rs17387019 and endometriosis.
|
23010532 |
2012 |
|
rs1971256
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.
|
28537267 |
2017 |
|
rs2294021
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the rs2294021 (CCDC22 gene) polymorphism could be associated with increased susceptibility to endometriosis in Brazilian women when the allele C is present.
|
28470452 |
2017 |
|
rs2812378
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found an association of CCL21 (rs2812378) and HLA-DRB1 (rs660895) with moderate to severe endometriosis.
|
20797713 |
2011 |
|
rs1799864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have used real-time PCR and FRET technologies to genotype and evaluate the variants CCR5-Delta32 and CCR2-V64I, as susceptibility factors in a cohort of Spanish women with endometriosis.
|
14981141 |
2004 |