|
rs1801253
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our data demonstrate that both Gly389Arg and Ser49Gly polymorphisms have very moderate influence on the risk of left ventricular hypertrophy and atrial fibrillation with no statistically significant effects on cardiac function and the development of cardiovascular complications.
|
24982877 |
2014 |
|
rs1801253
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The data suggest an association between the beta1AR Arg389Gly polymorphism and LVH, particularly the septal hypertrophy.
|
20731869 |
2010 |
|
rs1801253
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our findings show that the Arg389Gly polymorphism of the ADRB1 gene confers higher risk of left ventricular hypertrophy in human essential hypertension.
|
18298953 |
2008 |
|
rs4762
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Angiotensinogen M235T and T174M polymorphisms have individually been associated with elevated levels of plasma angiotensinogen, hypertension, and left ventricular hypertrophy.
|
17145981 |
2007 |
|
rs5443
|
|
|
0.030 |
GeneticVariation |
BEFREE |
GNB3 825 C>T is likely to be a significant risk factor for LVH but not for EH in the Emirati population, thereby strengthening the view that LVH is genetically a separate clinical entity.
|
15614196 |
2005 |
|
rs5443
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The GNB3 C825T gene polymorphism has recently been identified and associated with hypertension, obesity and left ventricular hypertrophy.
|
12566975 |
2003 |
|
rs4762
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The angiotensinogen T174M and M235T and the AT1-receptor A1166C polymorphisms were related to the change in LVH during antihypertensive treatment with an AT1-receptor antagonist; of these angiotensinogen T174M was the most powerful.
|
11910301 |
2002 |
|
rs5443
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Lack of association of G-protein subunit gene C825T polymorphism with left ventricular hypertrophy in essential hypertension.
|
12011775 |
2002 |
|
rs4762
|
|
|
0.030 |
GeneticVariation |
BEFREE |
1.The relationship between the angiotensinogen (AGT) T174M, angiotensin converting enzyme (ACE) insertion/deletion (I/D) and the angiotensin II type 1 receptor (AT1) genetic markers and left ventricular hypertrophy was examined in normal subjects and those with aortic stenosis.2.
|
8800593 |
1996 |
|
rs104894503
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We studied 140 carriers (G+) of the TPM1-Asp175Asn or MYBPC3-Gln1061X pathogenic variants for HCM: The G+/LVH+ group (n = 98) consisted of mutation carriers with LVH and the G+/LVH- group (n = 42) without LVH.
|
30497761 |
2019 |
|
rs1799983
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we investigated the association of three clinically relevant polymorphisms (promoter T786C, intronic 4a/b, and nonsynonymous G894T) in a case-control sample of 230 ethnically homogeneous (Caucasians) patients with essential hypertension, with (n = 64) and without (n = 166) clinically diagnosed LVH.Haplotype analysis was also performed.
|
20482221 |
2010 |
|
rs1799983
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A common variant of the eNOS gene (E298D) is an independent risk factor for left ventricular hypertrophy in human essential hypertension.
|
19132956 |
2009 |
|
rs104894503
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In HCM attributable to the Asp175Asn mutation in the alpha-tropomyosin gene, myocardial oxidative metabolism and FFA metabolism are increased and inversely related to LV hypertrophy at both the whole heart and regional level.
|
17556170 |
2007 |
|
rs11549465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The distribution differences of gene frequencies for rs11549465, rs11549467 and rs1957757 in HIF1A single nucleotide gene polymorphisms for LVH (+) and LVH (-) were statistically significant (p<0.05).
|
31599436 |
2019 |
|
rs11549467
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The distribution differences of gene frequencies for rs11549465, rs11549467 and rs1957757 in HIF1A single nucleotide gene polymorphisms for LVH (+) and LVH (-) were statistically significant (p<0.05).
|
31599436 |
2019 |
|
rs1957757
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The distribution differences of gene frequencies for rs11549465, rs11549467 and rs1957757 in HIF1A single nucleotide gene polymorphisms for LVH (+) and LVH (-) were statistically significant (p<0.05).
|
31599436 |
2019 |
|
rs2074192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ACE2 tagSNPs rs2074192 and rs2106809 as well as major haplotypes CCGC and TCGT may serve as novel risk markers for LVH in hypertensive patients.
|
30917908 |
2019 |
|
rs2106809
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ACE2 tagSNPs rs2074192 and rs2106809 as well as major haplotypes CCGC and TCGT may serve as novel risk markers for LVH in hypertensive patients.
|
30917908 |
2019 |
|
rs28933979
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Kaplan-Meier analysis demonstrated a significantly higher probability of the composite endpoint in the non-Val30Met group than in the Val30Met group (log-rank test: P = 0.002) and in patients with left ventricular hypertrophy than in patients without left ventricular hypertrophy (log-rank test: P < 0.001).
|
30284755 |
2019 |
|
rs755492182
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a rare c.740C>T (p.T247M) mutation in ACTN2, encoding α-actinin 2 in a HCM patient, who presented with left ventricular hypertrophy, outflow tract obstruction, and atrial fibrillation.
|
31680489 |
2019 |
|
rs28935197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
N215S patients showed later symptom onset (males: p< 0.0001, females: p<0.03), later development of left ventricular hypertrophy (LVH) (median survival without LVH: 41 (non-N215S) vs. 64 (N215S) years, p< 0.0001), later development of proteinuria (median survival without proteinuria 43 (non-N215S) vs 71 years (N215S), p< 0.0001), later occurrence of cerebrovascular events (stroke/ Transient Ischaemic Attacks (TIA); median survival without stroke: 74 years (non-N215S) vs. not reached (N215S), p< 0.02), later decline in renal function to GFR <60 ml/min/1.73m2 (median survival: 56 (non-N215S) vs. 72 (N215S) years, p< 0.01), and greater overall survival (median survival 81 (N215S) vs. 66 (non-N215S) years, p< 0.0006).
|
29621274 |
2018 |
|
rs861539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The XRCC3 241Thr/Met genotype was more frequent in the LVH (+) group than in the LVH (-) group (42.3 vs. 13.7%, χ2 = 7.85, p = 0.0051).
|
29626209 |
2018 |
|
rs1050606
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the luciferase experiment, ANXA5 rs1050606 had the most promoter activity in myocardial cells (P < .001).These results showed that ANXA5 rs1050606 was significantly associated with LVH in Chinese EH patients, likely via influencing ANXA5 expression in serum and in myocardial cells.
|
29095261 |
2017 |
|
rs1349963459
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to test the association between a functional polymorphism Glu37Asp (rs2296545) of the renalase gene and left ventricular hypertrophy in a large cohort of patients with aortic stenosis.
|
29065134 |
2017 |
|
rs2073618
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thalassemia patients having minor allele of OPG rs2073618, RANK rs75404003 and RANKL rs9594782 SNPs were at high risk for LVH as suggested by high odds ratio of 2.470, 3.783, and 2.148, respectively; however, none of the SNPs tested were statistically significantly associated after applying Bonferroni corrections for multiple testing adjustment.
|
28244588 |
2017 |