|
rs2476601
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The association between rs2476601 and JIA appears restricted to females, partly accounting for the predominance of females with this disease.
|
26291515 |
2015 |
|
rs2476601
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This meta-analysis showed the association between the T-allele and the T/T genotype and JIA (OR = 1.34, P = 0.03; OR = 1.97, P = 0.02) but did not reveal the association between the PTPN22 C1858T polymorphism and IBD, psoriasis, multiple sclerosis, Addison's disease and Celiac disease.
|
16760194 |
2007 |
|
rs2476601
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases.
|
15759012 |
2005 |
|
rs2476601
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Its +1858C>T (R620W) polymorphism has been shown to associate with a risk for multiple autoimmune diseases, including type 1 diabetes (T1D) and juvenile idiopathic arthritis (JIA).
|
17000021 |
2007 |
|
rs2476601
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Associations of STAT4 rs7574865 G/T and PTPN22 (rs2488457 G/C and rs2476601 C/T) polymorphisms with JIA have repeatedly been replicated in several Caucasian populations.
|
25781893 |
2015 |
|
rs2476601
|
|
|
0.090 |
GeneticVariation |
BEFREE |
However, C1858T polymorphism of PTPN22, another candidate gene of autoimmunity seems to be independent of JIA in Hungarian patients.
|
19210888 |
2009 |
|
rs2476601
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The minor allele of the R620W missense single-nucleotide polymorphism (SNP; rs2476601) in the PTPN22 (protein tyrosine phosphatase non-receptor 22) gene has been reported to be associated with multiple autoimmune diseases, including type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, juvenile idiopathic arthritis, autoimmune thyroiditis and vitiligo.
|
16464986 |
2006 |
|
rs2476601
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism of PTPN22, 1858C>T (rs2476601), disrupts an interaction motif in the protein, and is the most important non-HLA genetic risk factor for rheumatoid arthritis and the second most important for juvenile idiopathic arthritis.
|
25003765 |
2014 |
|
rs2476601
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This meta-analysis confirms that the PTPN22 1858 C/T polymorphism is associated with JIA susceptibility in Europeans and shows that the MIF -173 C/G polymorphism may be associated with susceptibility to JIA.
|
22327470 |
2012 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To study the relationship of C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene to toxicity and efficacy of methotrexate (MTX) in patients with juvenile idiopathic arthritis (JIA).
|
16142884 |
2005 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
C677T (rs1801133) polymorphism in MTHFR predicts nonresponse and/or adverse effects of MTX treatment in JIA patients.
|
29589488 |
2018 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To investigate whether methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and erythrocyte concentration of methotrexate (EMTX) could serve as predictors of methotrexate (MTX) efficacy and toxicity in patients with juvenile idiopathic arthritis (JIA).
|
20595278 |
2010 |
|
rs2004640
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The SNP rs2004640 was significantly associated with SLE, MS, and SSc, but not with JIA [odds ratio (OR)=1.06, 95% confidence interval (CI)=0.90-1.24, P=0.48] or RA (OR=1.03, 95%CI=0.95-1.11, P=0.44).
|
25036352 |
2014 |
|
rs2004640
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The frequency of the IRF5 rs2004640 T allele was significantly higher (69 vs 45%, P value = 0.0013) in JIA group as compared to control.
|
29423720 |
2018 |
|
rs30187
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) in ERAP1 (rs30187) and IL23R (rs11209026) were genotyped in JIA cases (n = 1,054) and healthy controls (n = 5,200).
|
21281511 |
2011 |
|
rs30187
|
|
|
0.020 |
GeneticVariation |
BEFREE |
ERAP1 rs30187 SNP was shown to confer risk in the enthesitis-related arthritis (ERA) category of JIA.
|
28161768 |
2017 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To investigate whether methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and erythrocyte concentration of methotrexate (EMTX) could serve as predictors of methotrexate (MTX) efficacy and toxicity in patients with juvenile idiopathic arthritis (JIA).
|
20595278 |
2010 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To study the relationship of C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene to toxicity and efficacy of methotrexate (MTX) in patients with juvenile idiopathic arthritis (JIA).
|
16142884 |
2005 |
|
rs4986790
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SNP of TLR2, NLRP3, and TLR4 (Asp299Gly) were not associated with jSpA or JIA.
|
25920454 |
2015 |
|
rs4986790
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No linkage or association was seen for Asp299Gly or Thr399Ile SNPs of TLR4 with JIA susceptibility.
|
15498795 |
2005 |
|
rs4986791
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Statistically significant difference in genotype frequency for Thr399Ile SNP of TLR4 was observed in the jSpA (χ2 = 6.705, p = 0.035) and not in the JIA group (χ2 = 3005, p = 0.223).
|
25920454 |
2015 |
|
rs4986791
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No linkage or association was seen for Asp299Gly or Thr399Ile SNPs of TLR4 with JIA susceptibility.
|
15498795 |
2005 |
|
rs7574865
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our data strengthen STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms as susceptibility factors for JIA.
|
25781893 |
2015 |
|
rs7574865
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our meta-analysis revealed that the STAT4 rs7574865 polymorphism is associated with four autoimmune diseases with systemic pathology, including systemic lupus erythematosus (OR = 1.52; 95% CI = 1.48 - 1.56, P<1.0 × 10(-16)), rheumatoid arthritis (OR = 1.27; 95% CI = 1.21 - 1.33, P < 1.00 × 10(-16)), systemic sclerosis (OR = 1.38; 95% CI = 1.27 - 1.50, P < 1.44 × 10(-14)), and primary Sjogren's syndrome (OR = 1.32; 95% CI = 1.01 - 1.73, P = 4.40 × 10(-2)), while no association was found with type I diabetes, juvenile idiopathic arthritis, ulcerative colitis and Crohn's disease.
|
23628400 |
2013 |
|
rs1003706636
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant difference in genotype frequency for Thr399Ile SNP of TLR4 was observed in the jSpA (χ2 = 6.705, p = 0.035) and not in the JIA group (χ2 = 3005, p = 0.223).
|
25920454 |
2015 |