Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
MTHFR
0.030 GeneticVariation BEFREE C677T (rs1801133) polymorphism in MTHFR predicts nonresponse and/or adverse effects of MTX treatment in JIA patients. 29589488

2018
dbSNP: rs41295061
rs41295061 		0.010 GeneticVariation BEFREE A second SNP (rs41295061) also showed modest evidence for association with JIA (OR 0.80 [95% CI 0.63-1.0], P=0.05). 19116909

2009
dbSNP: rs653178
rs653178
ATXN2
0.010 GeneticVariation BEFREE A second SNP, rs653178 in ATXN2, also showed nominal evidence for association with JIA (p(trend)=0.02, OR=1.13, 95% CI 1.02 to 1.25). 20647273

2010
dbSNP: rs35761398
rs35761398
CNR2
0.010 GeneticVariation BEFREE A significant difference in genotype distribution of the CB2 Q63R variant (CNR2 rs35761398) between oligo/poly-articular JIA patients and controls was found (p = 0.001). 25974389

2015
dbSNP: rs2476601
rs2476601
PTPN22 ; AP4B1-AS1
0.090 GeneticVariation BEFREE A single nucleotide polymorphism of PTPN22, 1858C>T (rs2476601), disrupts an interaction motif in the protein, and is the most important non-HLA genetic risk factor for rheumatoid arthritis and the second most important for juvenile idiopathic arthritis. 25003765

2014
dbSNP: rs1051266
rs1051266
SLC19A1
0.010 GeneticVariation BEFREE ABCB1 rs1045642, ABCC3 rs4793665, and SLC19A1 rs1051266 polymorphisms were associated with response to MTX in 287 patients with JIA studied longitudinally. 22859359

2012
dbSNP: rs10954213
rs10954213
IRF5
0.010 GeneticVariation BEFREE Allele and genotype frequencies of the rs10954213 and rs3807306 did not show any significant difference between JIA and control group. 29423720

2018
dbSNP: rs3807306
rs3807306
IRF5
0.010 GeneticVariation BEFREE Allele and genotype frequencies of the rs10954213 and rs3807306 did not show any significant difference between JIA and control group. 29423720

2018
dbSNP: rs2476601
rs2476601
PTPN22 ; AP4B1-AS1
0.090 GeneticVariation BEFREE Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases. 15759012

2005
dbSNP: rs2395148
rs2395148
TSBP1 ; TSBP1-AS1
0.800 GeneticVariation GWASCAT Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis. 18576341

2008
dbSNP: rs2395148
rs2395148
TSBP1 ; TSBP1-AS1
0.800 GeneticVariation GWASDB Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis. 18576341

2008
dbSNP: rs2476601
rs2476601
PTPN22 ; AP4B1-AS1
0.090 GeneticVariation BEFREE Associations of STAT4 rs7574865 G/T and PTPN22 (rs2488457 G/C and rs2476601 C/T) polymorphisms with JIA have repeatedly been replicated in several Caucasian populations. 25781893

2015
dbSNP: rs1801133
rs1801133
MTHFR
0.010 GeneticVariation BEFREE C677T (rs1801133) polymorphism in MTHFR predicts nonresponse and/or adverse effects of MTX treatment in JIA patients. 29589488

2018
dbSNP: rs30187
rs30187
ERAP1
0.020 GeneticVariation BEFREE ERAP1 rs30187 SNP was shown to confer risk in the enthesitis-related arthritis (ERA) category of JIA. 28161768

2017
dbSNP: rs4688011
rs4688011
TIMMDC1
T 0.800 GeneticVariation GWASCAT Gene expression data on 68 JIA cases and 23 local controls showed cis expression quantitative trait locus associations for C3orf1 SNP rs4688011 (P = 0.024 or P = 0.034, depending on the probe set) and JMJD1C SNPs rs6479891 and rs12411988 (P = 0.01 or P = 0.04, depending on the probe set and P = 0.008, respectively). 22354554

2012
dbSNP: rs4688011
rs4688011
TIMMDC1
T 0.800 GeneticVariation GWASDB Gene expression data on 68 JIA cases and 23 local controls showed cis expression quantitative trait locus associations for C3orf1 SNP rs4688011 (P = 0.024 or P = 0.034, depending on the probe set) and JMJD1C SNPs rs6479891 and rs12411988 (P = 0.01 or P = 0.04, depending on the probe set and P = 0.008, respectively). 22354554

2012
dbSNP: rs6479891
rs6479891
JMJD1C
T 0.800 GeneticVariation GWASCAT Gene expression data on 68 JIA cases and 23 local controls showed cis expression quantitative trait locus associations for C3orf1 SNP rs4688011 (P = 0.024 or P = 0.034, depending on the probe set) and JMJD1C SNPs rs6479891 and rs12411988 (P = 0.01 or P = 0.04, depending on the probe set and P = 0.008, respectively). 22354554

2012
dbSNP: rs6479891
rs6479891
JMJD1C
T 0.800 GeneticVariation GWASDB Gene expression data on 68 JIA cases and 23 local controls showed cis expression quantitative trait locus associations for C3orf1 SNP rs4688011 (P = 0.024 or P = 0.034, depending on the probe set) and JMJD1C SNPs rs6479891 and rs12411988 (P = 0.01 or P = 0.04, depending on the probe set and P = 0.008, respectively). 22354554

2012
dbSNP: rs12411988
rs12411988
REEP3
C 0.800 GeneticVariation GWASCAT Gene expression data on 68 JIA cases and 23 local controls showed cis expression quantitative trait locus associations for C3orf1 SNP rs4688011 (P = 0.024 or P = 0.034, depending on the probe set) and JMJD1C SNPs rs6479891 and rs12411988 (P = 0.01 or P = 0.04, depending on the probe set and P = 0.008, respectively). 22354554

2012
dbSNP: rs12411988
rs12411988
REEP3
C 0.800 GeneticVariation GWASDB Gene expression data on 68 JIA cases and 23 local controls showed cis expression quantitative trait locus associations for C3orf1 SNP rs4688011 (P = 0.024 or P = 0.034, depending on the probe set) and JMJD1C SNPs rs6479891 and rs12411988 (P = 0.01 or P = 0.04, depending on the probe set and P = 0.008, respectively). 22354554

2012
dbSNP: rs12719740
rs12719740
FAM169B
T 0.800 GeneticVariation GWASDB Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. 22354554

2012
dbSNP: rs12719740
rs12719740
FAM169B
T 0.800 GeneticVariation GWASCAT Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. 22354554

2012
dbSNP: rs10761744
rs10761744
JMJD1C
0.700 GeneticVariation GWASDB Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. 22354554

2012
dbSNP: rs10761745
rs10761745
JMJD1C
0.700 GeneticVariation GWASDB Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. 22354554

2012
dbSNP: rs11817689
rs11817689 		0.700 GeneticVariation GWASDB Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. 22354554

2012