|
rs4986790
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No linkage or association was seen for Asp299Gly or Thr399Ile SNPs of TLR4 with JIA susceptibility.
|
15498795 |
2005 |
|
rs4986791
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No linkage or association was seen for Asp299Gly or Thr399Ile SNPs of TLR4 with JIA susceptibility.
|
15498795 |
2005 |
|
rs2476601
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases.
|
15759012 |
2005 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To study the relationship of C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene to toxicity and efficacy of methotrexate (MTX) in patients with juvenile idiopathic arthritis (JIA).
|
16142884 |
2005 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To study the relationship of C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene to toxicity and efficacy of methotrexate (MTX) in patients with juvenile idiopathic arthritis (JIA).
|
16142884 |
2005 |
|
rs237025
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The M55V substitution in the SUMO4 gene is not associated with susceptibility to RA or JIA in the UK population studied.
|
16159953 |
2005 |
|
rs2476601
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The minor allele of the R620W missense single-nucleotide polymorphism (SNP; rs2476601) in the PTPN22 (protein tyrosine phosphatase non-receptor 22) gene has been reported to be associated with multiple autoimmune diseases, including type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, juvenile idiopathic arthritis, autoimmune thyroiditis and vitiligo.
|
16464986 |
2006 |
|
rs2476601
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This meta-analysis showed the association between the T-allele and the T/T genotype and JIA (OR = 1.34, P = 0.03; OR = 1.97, P = 0.02) but did not reveal the association between the PTPN22 C1858T polymorphism and IBD, psoriasis, multiple sclerosis, Addison's disease and Celiac disease.
|
16760194 |
2007 |
|
rs2476601
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Its +1858C>T (R620W) polymorphism has been shown to associate with a risk for multiple autoimmune diseases, including type 1 diabetes (T1D) and juvenile idiopathic arthritis (JIA).
|
17000021 |
2007 |
|
rs231775
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that C-318T, A49G, CT60, and haplotypes tagged by these CTLA4 SNPs are not associated with JIA or major JIA subtypes.
|
18576317 |
2008 |
|
rs2395148
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis.
|
18576341 |
2008 |
|
rs2395148
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis.
|
18576341 |
2008 |
|
rs2104286
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs2104286 within the IL2RA/CD25 gene was significantly associated with UK JI</span>A cases (OR for the allele 0.76 [95% CI 0.66-0.88], P for trend=0.0002).
|
19116909 |
2009 |
|
rs41295061
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A second SNP (rs41295061) also showed modest evidence for association with JIA (OR 0.80 [95% CI 0.63-1.0], P=0.05).
|
19116909 |
2009 |
|
rs12046117
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis.
|
19116933 |
2009 |
|
rs12046117
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis.
|
19116933 |
2009 |
|
rs1042713
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotypes and haplotypes of two ADRB2 variants (G16R and Q27E) were determined in 348 children with JIA and 448 healthy controls by direct molecular haplotyping using melting-curve analysis of a fluorescently labelled loci-spanning probe.
|
19177262 |
2009 |
|
rs1042714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotypes and haplotypes of two ADRB2 variants (G16R and Q27E) were determined in 348 children with JIA and 448 healthy controls by direct molecular haplotyping using melting-curve analysis of a fluorescently labelled loci-spanning probe.
|
19177262 |
2009 |
|
rs2476601
|
|
|
0.090 |
GeneticVariation |
BEFREE |
However, C1858T polymorphism of PTPN22, another candidate gene of autoimmunity seems to be independent of JIA in Hungarian patients.
|
19210888 |
2009 |
|
rs10499194
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The strongest associations with JIA risk or protection were observed for TNFAIP3 variants rs10499194 (OR 0.74 [95% CI 0.61-0.91], P < 0.004) and rs6920220 (OR 1.30 [95% CI 1.05-1.61], P = 0.015).
|
19565500 |
2009 |
|
rs6920220
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The strongest associations with JIA risk or protection were observed for TNFAIP3 variants rs10499194 (OR 0.74 [95% CI 0.61-0.91], P < 0.004) and rs6920220 (OR 1.30 [95% CI 1.05-1.61], P = 0.015).
|
19565500 |
2009 |
|
rs12708716
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The intron 22 SNP, rs6498169, was associated with RA (p=0.006) and JIA (p=0.016) and the intron 19 SNPs, rs12708716/rs12917716, with T1D (p=1x10-5) and AD (p=2x10-4).
|
19734133 |
2010 |
|
rs12917716
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The intron 22 SNP, rs6498169, was associated with RA (p=0.006) and JIA (p=0.016) and the intron 19 SNPs, rs12708716/rs12917716, with T1D (p=1x10-5) and AD (p=2x10-4).
|
19734133 |
2010 |
|
rs6498169
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The intron 22 SNP, rs6498169, was associated with RA (p=0.006) and JIA (p=0.016) and the intron 19 SNPs, rs12708716/rs12917716, with T1D (p=1x10-5) and AD (p=2x10-4).
|
19734133 |
2010 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To investigate whether methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and erythrocyte concentration of methotrexate (EMTX) could serve as predictors of methotrexate (MTX) efficacy and toxicity in patients with juvenile idiopathic arthritis (JIA).
|
20595278 |
2010 |