|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
CTD_human |
Variation in complement factor 3 is associated with risk of age-related macular degeneration.
|
17767156 |
2007 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotyping was performed for AMD risk polymorphisms associated with age-related maculopathy susceptibility 2 (ARMS2), high-temperature requirement factor A1 (HTRA1), complement factor H (CFH), and complement C3.
|
20238042 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.
|
20861866 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide analysis of disease progression in age-related macular degeneration.
|
29346644 |
2018 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
PPARGC1A influences activation of the AMD-associated complement component 3 (C3) promoter fragment and CFB influences activation and proteolysis of C3.
|
23335958 |
2013 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
CTD_human |
Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.
|
24036952 |
2013 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of polymorphisms in complement component 3 with age-related macular degeneration in an Iranian population.
|
27029644 |
2017 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.
|
20861866 |
2010 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial.
|
31474439 |
2020 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
CTD_human |
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration.
|
24036949 |
2013 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotyping was performed for AMD risk polymorphisms associated with age-related maculopathy susceptibility 2 (ARMS2), high temperature requirement factor A1 (HTRA1), complement factor H, and complement C3, and the risk of AMD was predicted based on genotype alone or in combination with the CEP markers.
|
19202148 |
2009 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
C3 R102G polymorphism increases risk of age-related macular degeneration.
|
18325906 |
2008 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Complement C3 variant and the risk of age-related macular degeneration.
|
17634448 |
2007 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Complement C3, C2, and factor B gene polymorphisms and age-related macular degeneration in a Greek cohort study.
|
24519512 |
2014 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The association between the rs2230199 C>G single nucleotide polymorphism (SNP) in complement component 3 and age-related macular degeneration (AMD) risk has been examined extensively but the results are not consistent among studies.
|
26505407 |
2015 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Joint association of complement component 3 and CC-cytokine ligand2 (CCL2) or complement component 3 and CFH polymorphisms in age-related macular degeneration.
|
28095095 |
2017 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
CTD_human |
A rare nonsynonymous sequence variant in C3 is associated with high risk of age-related macular degeneration.
|
24036950 |
2013 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our study showed a significant association between variants in the C3 gene and AMD and further highlights the crucial role of the complement pathway in the etiology of AMD.
|
19168221 |
2009 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: a HuGE review and meta-analysis.
|
21576320 |
2011 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|