C3, complement C3, 718

N. diseases: 343; N. variants: 49
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.010 Biomarker group BEFREE Herpes simplex virus glycoprotein C functions in viral entry and binds to complement component C3b, inhibiting complement-mediated immunity. 31826995 2020
CUI: C0023530
Disease: Leukopenia
Leukopenia 		0.010 Biomarker disease BEFREE The ANCA-positive cocaine-levamisole cohort at onset were characterized by younger age (45 ± 12 vs 53 ± 14 years, p = 0.04), superficial skin necrosis (82% vs 54%, p = 0.036), depressed complement C3 (27% vs 4%, p = 0.33), antiphospholipid antibodies (50% vs 4%, p < 0.001), neutropenia (18% vs 0%, p = 0.044), and elevated antimyeloperoxidase (MPO) antibody levels (100% vs 67%, p < 0.001). 30273264 2020
CUI: C0027947
Disease: Neutropenia
Neutropenia 		0.010 Biomarker disease BEFREE The ANCA-positive cocaine-levamisole cohort at onset were characterized by younger age (45 ± 12 vs 53 ± 14 years, p = 0.04), superficial skin necrosis (82% vs 54%, p = 0.036), depressed complement C3 (27% vs 4%, p = 0.33), antiphospholipid antibodies (50% vs 4%, p < 0.001), neutropenia (18% vs 0%, p = 0.044), and elevated antimyeloperoxidase (MPO) antibody levels (100% vs 67%, p < 0.001). 30273264 2020
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma 		0.010 Biomarker disease BEFREE Therefore, ASP and METRNL potentially could be used as markers for differentiating MM from benign diseases. 31570005 2020
CUI: C1735608
Disease: SLE flare
SLE flare 		0.010 Biomarker disease BEFREE Complement C3 and C4 also showed a high discriminatory capacity for SLE flare (AUC 0.804 and 0.837, respectively). 31773496 2020
CUI: C0002726
Disease: Amyloidosis
Amyloidosis 		0.010 Biomarker disease BEFREE Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy. 31433986 2019
CUI: C0004610
Disease: Bacteremia
Bacteremia 		0.010 GeneticVariation disease BEFREE By contrast, a cspZ-deficient mutant and a strain that expressed an FH-nonbinding CspZ variant were impaired in their ability to cause bacteraemia and colonize tissues of mice or quail; virulence of these mutants was however restored in complement C3-deficient mice. 30571845 2019
CUI: C0005129
Disease: Bernard-Soulier Syndrome
Bernard-Soulier Syndrome 		0.010 AlteredExpression disease BEFREE On evaluation, she had low complement C3 levels, but there were no features to suggest any metabolic complication.She was diagnosed with BSS. 30604443 2019
CUI: C0008149
Disease: Chlamydia Infections
Chlamydia Infections 		0.010 AlteredExpression group BEFREE Sulforaphane promotes chlamydial infection by suppressing mitochondrial protein oxidation and activation of complement C3. 30367535 2019
CUI: C0024312
Disease: Lymphopenia
Lymphopenia 		0.010 AlteredExpression disease BEFREE The presence of albuminuria, lymphopenia and low complement C3 levels were independent prognostic predictors of short-term mortality in SLE patients with PI. 30968568 2019
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.010 Biomarker disease BEFREE It is known, that ASP can cause several toxicities such as hypersensitivity, pancreatitis, as well as severe lipid and coagulation disturbances. 31515171 2019
CUI: C0040558
Disease: Toxoplasmosis
Toxoplasmosis 		0.010 Biomarker disease BEFREE A Double-Edged Sword: Complement Component 3 in Toxoplasma gondii Infection. 30515942 2019
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.010 Biomarker disease BEFREE This is the first evidence that ASP can regulate MSCs function and enhance MSCs therapy for ischemic heart disease. 31194992 2019
CUI: C0235989
Disease: Renal interstitial fibrosis
Renal interstitial fibrosis 		0.010 Biomarker disease BEFREE Thus, complement C3 exacerbates renal interstitial fibrosis by facilitating macrophage M1 polarization, promoting proinflammatory cytokine expression, and deteriorating peritubular capillary rarefaction in the kidney. 31461345 2019
CUI: C0264774
Disease: Mitral and aortic incompetence
Mitral and aortic incompetence 		0.010 GeneticVariation disease BEFREE Salient features included mitral and aortic regurgitation that worsened during the acute illness, painful pericarditis, and high troponin; severe acute kidney injury with oliguria, hematuria, and macroalbuminuria; reduced complement (C3); and elevated streptococcal serology. 31516109 2019
CUI: C0343386
Disease: Clostridium difficile infection
Clostridium difficile infection 		0.010 Biomarker disease BEFREE We evaluated whether a diagnostic stewardship initiative consisting of ASP preauthorization paired with education could reduce false-positive hospital-onset (HO) Clostridioides difficile infection (CDI). 30786942 2019
CUI: C0543698
Disease: Hypersensitive syndrome
Hypersensitive syndrome 		0.010 Biomarker disease BEFREE Inflammatory kidney injury in trichloroethylene hypersensitivity syndrome mice: Possible role of C3a receptor in the accumulation of Th17 phenotype. 31614297 2019
CUI: C0553723
Disease: Squamous cell carcinoma of skin
Squamous cell carcinoma of skin 		0.010 AlteredExpression disease BEFREE Complement C3 has been shown to be highly expressed in cutaneous squamous cell carcinoma (cSCC) tumour tissues and is correlated with tumour cell growth. 30825266 2019
CUI: C0566602
Disease: Primary sclerosing cholangitis
Primary sclerosing cholangitis 		0.010 AlteredExpression disease BEFREE IgG4 fucosylation and IgG1/2/3 hybrid structures negatively correlated with complement C3 and C4 levels in IgG4-RD (P < 0.01), but not PSC. 30345709 2019
CUI: C0677607
Disease: Hashimoto Disease
Hashimoto Disease 		0.010 AlteredExpression disease BEFREE In addition, there was an increased expression of MKi67 and complement C3 in PTC of PTC/AIT+ when compared with PTC/AIT-. 31579073 2019
CUI: C0687720
Disease: Central Diabetes Insipidus
Central Diabetes Insipidus 		0.010 Biomarker disease BEFREE We evaluated whether a diagnostic stewardship initiative consisting of ASP preauthorization paired with education could reduce false-positive hospital-onset (HO) Clostridioides difficile infection (CDI). 30786942 2019
CUI: C0730285
Disease: Diabetic macular edema
Diabetic macular edema 		0.010 Biomarker disease BEFREE Eight proteins, including complement C3, were identified to be increased in both BK-stimulated rat retina and in human DME vitreous. 31351056 2019
CUI: C0876973
Disease: Infectious Lung Disorder
Infectious Lung Disorder 		0.010 AlteredExpression group BEFREE The presence of albuminuria, lymphopenia and low complement C3 levels were independent prognostic predictors of short-term mortality in SLE patients with PI. 30968568 2019
CUI: C0920350
Disease: Autoimmune thyroiditis
Autoimmune thyroiditis 		0.010 AlteredExpression disease BEFREE In addition, there was an increased expression of MKi67 and complement C3 in PTC of PTC/AIT+ when compared with PTC/AIT-. 31579073 2019
CUI: C0949664
Disease: Tauopathies
Tauopathies 		0.010 Biomarker group BEFREE Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy. 31433986 2019