|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotyping was performed for AMD risk polymorphisms associated with age-related maculopathy susceptibility 2 (ARMS2), high-temperature requirement factor A1 (HTRA1), complement factor H (CFH), and complement C3.
|
20238042 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.
|
20861866 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide analysis of disease progression in age-related macular degeneration.
|
29346644 |
2018 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
PPARGC1A influences activation of the AMD-associated complement component 3 (C3) promoter fragment and CFB influences activation and proteolysis of C3.
|
23335958 |
2013 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of polymorphisms in complement component 3 with age-related macular degeneration in an Iranian population.
|
27029644 |
2017 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.
|
20861866 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotyping was performed for AMD risk polymorphisms associated with age-related maculopathy susceptibility 2 (ARMS2), high temperature requirement factor A1 (HTRA1), complement factor H, and complement C3, and the risk of AMD was predicted based on genotype alone or in combination with the CEP markers.
|
19202148 |
2009 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
C3 R102G polymorphism increases risk of age-related macular degeneration.
|
18325906 |
2008 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Complement C3 variant and the risk of age-related macular degeneration.
|
17634448 |
2007 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The association between the rs2230199 C>G single nucleotide polymorphism (SNP) in complement component 3 and age-related macular degeneration (AMD) risk has been examined extensively but the results are not consistent among studies.
|
26505407 |
2015 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our study showed a significant association between variants in the C3 gene and AMD and further highlights the crucial role of the complement pathway in the etiology of AMD.
|
19168221 |
2009 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of rare variants in the CFH, CFI, C9, and C3 genes with AMD, serum levels of corresponding proteins, and C3b degradation ability of CFH and CFI variant carriers.
|
27918759 |
2017 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Based on the search criteria for manuscripts reporting AMD susceptibility related to CC3 in nine SNPs, 57 case-control studies from 22 different articles were retrieved.
|
25688879 |
2015 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Subjects were analyzed for single nucleotide polymorphisms in factor H (CFH), factor B-C2 (BF-C2) and complement C3 (C3) genes which were previously found to be associated with AMD.
|
18596911 |
2008 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To explore whether additional rare variants in the C3 gene are associated with AMD, we sequenced all coding exons in 84 unrelated AMD cases.
|
24736606 |
2014 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.
|
22705344 |
2012 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
|
26691988 |
2016 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic loci (complement factor H [CFH], complement factor B [CFB], the age-related maculopathy susceptibility 2 locus containing the hypothetical gene [LOC387715]/the high-temperature requirement A-1 [HTRA1], and complement component 3 [C3]) that were already known to be associated with AMD were identified.
|
21197116 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether the previously reported noncoding variant of the complement factor H (CFH) gene and two coding variants of the complement component 3 (C3) gene are associated with exudative age-related macular degeneration (AMD) in Chinese patients.
|
19850835 |
2010 |