|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotyping was performed for AMD risk polymorphisms associated with age-related maculopathy susceptibility 2 (ARMS2), high-temperature requirement factor A1 (HTRA1), complement factor H (CFH), and complement C3.
|
20238042 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
PPARGC1A influences activation of the AMD-associated complement component 3 (C3) promoter fragment and CFB influences activation and proteolysis of C3.
|
23335958 |
2013 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of polymorphisms in complement component 3 with age-related macular degeneration in an Iranian population.
|
27029644 |
2017 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial.
|
31474439 |
2020 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotyping was performed for AMD risk polymorphisms associated with age-related maculopathy susceptibility 2 (ARMS2), high temperature requirement factor A1 (HTRA1), complement factor H, and complement C3, and the risk of AMD was predicted based on genotype alone or in combination with the CEP markers.
|
19202148 |
2009 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Complement C3 variant and the risk of age-related macular degeneration.
|
17634448 |
2007 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Complement C3, C2, and factor B gene polymorphisms and age-related macular degeneration in a Greek cohort study.
|
24519512 |
2014 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The association between the rs2230199 C>G single nucleotide polymorphism (SNP) in complement component 3 and age-related macular degeneration (AMD) risk has been examined extensively but the results are not consistent among studies.
|
26505407 |
2015 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Joint association of complement component 3 and CC-cytokine ligand2 (CCL2) or complement component 3 and CFH polymorphisms in age-related macular degeneration.
|
28095095 |
2017 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our study showed a significant association between variants in the C3 gene and AMD and further highlights the crucial role of the complement pathway in the etiology of AMD.
|
19168221 |
2009 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: a HuGE review and meta-analysis.
|
21576320 |
2011 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of rare variants in the CFH, CFI, C9, and C3 genes with AMD, serum levels of corresponding proteins, and C3b degradation ability of CFH and CFI variant carriers.
|
27918759 |
2017 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Based on the search criteria for manuscripts reporting AMD susceptibility related to CC3 in nine SNPs, 57 case-control studies from 22 different articles were retrieved.
|
25688879 |
2015 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Subjects were analyzed for single nucleotide polymorphisms in factor H (CFH), factor B-C2 (BF-C2) and complement C3 (C3) genes which were previously found to be associated with AMD.
|
18596911 |
2008 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort.
|
20157618 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To explore whether additional rare variants in the C3 gene are associated with AMD, we sequenced all coding exons in 84 unrelated AMD cases.
|
24736606 |
2014 |
|
Age related macular degeneration
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Estimation of systemic complement C3 activity in age-related macular degeneration.
|
17420372 |
2007 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic loci (complement factor H [CFH], complement factor B [CFB], the age-related maculopathy susceptibility 2 locus containing the hypothetical gene [LOC387715]/the high-temperature requirement A-1 [HTRA1], and complement component 3 [C3]) that were already known to be associated with AMD were identified.
|
21197116 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether the previously reported noncoding variant of the complement factor H (CFH) gene and two coding variants of the complement component 3 (C3) gene are associated with exudative age-related macular degeneration (AMD) in Chinese patients.
|
19850835 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this post hoc analysis of cross-sectional data from US participants in the Comparison of AMD Treatments Trials, genotyping was performed in 835 participants with TaqMan assays for the SNPs rs1061170 (Y402H variant in CFH), rs800292 (rs800292" genes_norm="3075">I62V variant in CFH), rs10490924 (rs10490924;s10490924" genes_norm="387715;717">A69S variant in ARMS2), rs11200638 (HTRA1), rs547154 (C2), rs2230199 (rs2230199" genes_norm="5654;718">R102G variant in C3), rs10468017 (LIPC), and rs4151667 (L9H variant in CFB).
|
29801032 |
2018 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis.
|
30352574 |
2018 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
While significant but modest associations were identified between the complement factor H, the age-related maculopathy susceptibility protein 2, and the complement component 3 single nucleotide polymorphisms and AD, these were different in direction or genetic model to that observed in AMD.
|
22300950 |
2012 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the associations of haplotype-tagging single nucleotide polymorphisms (SNPs) in the complement component 3 (C3) gene with both neovascular AMD and PCV, and potential epistatic effects on C3.
|
25388911 |
2014 |
|
Complement component 3 deficiency
|
0.630 |
Biomarker
|
disease |
BEFREE |
The occurrence of an immune complex-like disease (with characteristics of the HCVS) in a patient with a familial deficiency of C3 suggests that the preexisting C3 deficiency may predispose such persons to certain diseases.
|
7369233 |
1980 |
|
Complement component 3 deficiency
|
0.630 |
Biomarker
|
disease |
BEFREE |
The current studies were undertaken to characterize the cDNA for wild-type canine C3 and identify the molecular basis for hereditary canine C3 deficiency.
|
9510185 |
1998 |