C3, complement C3, 718

N. diseases: 343; N. variants: 49
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C3151071
Disease: COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE
COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE 		0.700 CausalMutation disease CLINVAR
CUI: C3151071
Disease: COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE
COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE 		0.700 Biomarker disease CTD_human
CUI: C1332655
Disease: Complement component 3 deficiency
Complement component 3 deficiency 		0.630 CausalMutation disease CLINVAR
CUI: C2752037
Disease: HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 5
HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 5 		0.600 SusceptibilityMutation disease CLINVAR
CUI: C2931788
Disease: Atypical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome 		0.600 Biomarker disease CTD_human
CUI: C1969651
Disease: Macular Degeneration, Age-Related, 9
Macular Degeneration, Age-Related, 9 		0.500 Biomarker disease CTD_human
CUI: C0019061
Disease: Hemolytic-Uremic Syndrome
Hemolytic-Uremic Syndrome 		0.410 Biomarker disease HPO
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.400 Biomarker disease HPO
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.340 Biomarker group HPO
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.200 Biomarker disease HPO
CUI: C0018965
Disease: Hematuria
Hematuria 		0.130 Biomarker phenotype HPO
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.110 Biomarker group HPO
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.110 Biomarker disease HPO
CUI: C0003460
Disease: Anuria
Anuria 		0.100 Biomarker phenotype HPO
CUI: C0033687
Disease: Proteinuria
Proteinuria 		0.100 Biomarker phenotype HPO
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia 		0.100 Biomarker phenotype HPO
CUI: C0151539
Disease: Blood urea increased
Blood urea increased 		0.100 Biomarker phenotype HPO
CUI: C0221021
Disease: Microangiopathic hemolytic anemia
Microangiopathic hemolytic anemia 		0.100 Biomarker disease HPO
CUI: C0700225
Disease: Serum creatinine raised
Serum creatinine raised 		0.100 Biomarker phenotype HPO
CUI: C1837512
Disease: Decreased serum complement C3
Decreased serum complement C3 		0.100 Biomarker phenotype HPO
CUI: C1844383
Disease: Recurrent bacterial infection
Recurrent bacterial infection 		0.100 Biomarker phenotype HPO
CUI: C4015971
Disease: MACULAR DEGENERATION, AGE-RELATED, 9, SUSCEPTIBILITY TO
MACULAR DEGENERATION, AGE-RELATED, 9, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury 		0.200 Therapeutic disease RGD "Beneficial effect of the polysaccharides from Bupleurum smithii var. parvifolium on ""two-hit"" acute lung injury in rats." 22763771 2012
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis 		0.050 Biomarker disease BEFREE IgA nephropathy (IgAN) is a complex syndrome characterized by deposition of IgA and IgA containing immune complexes (ICs) composed of IgG and complement C3 proteins in the mesangial area of glomeruli. 23593433 2013