|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
There are no studies on purinergic receptors in the DBA/2J model of glaucoma and their relation to the development of the pathology, so the aim of this study was to make an approach to the purinergic mechanisms involved in glaucoma.
|
29085298 |
2017 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The beneficial effects of neuroglobin in DBA/2J retinas confirm this protein to be a promising candidate for treating glaucoma.
|
28540323 |
2017 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The DBA/2J mouse has been described as a model for congenital experimental glaucoma.
|
28516453 |
2017 |
|
Intraocular pressure disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBA/2J mice exhibit elevated intraocular pressure, progressive degeneration of their retinal ganglion cells, and optic neuropathy that resembles glaucoma.
|
28540323 |
2017 |
|
Intraocular pressure disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
On the other hand, there were significant changes in the purinergic receptor expression in DBA/2J suggesting that elevated IOP in these animals could be related to an increase of P2Y<sub>2</sub> expression and a decrease in P2Y<sub>1</sub> receptors.
|
29085298 |
2017 |
|
Intraocular pressure disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The topical application of Ap<sub>4</sub>A when IOP is maximal (9-12 months) reduced IOP 30.6 ± 6.6% in the DBA/2J and 17.9 ± 4.0% in the C57BL/6J mice.
|
27848070 |
2017 |
|
Intraocular pressure disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the GpnmbR150X mutation leads to increased IOP and glaucoma in DBA/2J mice, development of anterior segment and retinal defects in D2.Ppcd1 animals does not depend upon presence of the GpnmbR150X mutation.
|
28981549 |
2017 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identification of a mutation in the IL-20RB gene in a glaucoma pedigree and changes in expression levels of IL-20 family members in the DBA/2J mouse suggest that disruption of normal IL-20 signaling in the eye may contribute to degenerative processes associated with glaucoma.
|
26903709 |
2016 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Remarkably, one-time intraocular adeno-associated virus-mediated gene delivery of sFasL provides complete and sustained neuroprotection in the chronic DBA/2J and acute microbead-induced models of glaucoma, even in the presence of elevated intraocular pressure.
|
27849168 |
2016 |
|
Glaucoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, the impact of the Akita mutation on glaucoma was assessed using DBA/2J (D2) mice, a widely used mouse model of ocular hypertension induced glaucoma.
|
25207540 |
2014 |
|
Intraocular pressure disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
To identify the sphingolipid and ceramide species and their quantitative differences between normotensive and hypertensive intraocular pressure states in DBA/2J mouse aqueous humor (AH).
|
25014247 |
2014 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBA/1J mice with CIA that received IL-17-/- donor bone marrow showed potently inhibited development and severity of clinical arthritis as compared with CIA mice that received WT bone marrow.
|
23114425 |
2012 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CIA was induced in DBA/1J mice.Arthritic mice were treated with bosentan (100 mg/kg) once a day, starting from the day when arthritis was clinically detectable.
|
22249931 |
2012 |
|
Intraocular pressure disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together with previous studies, we show cochlin is involved in regulation of intraocular pressure in DBA/2J potentially through mechanosensing of the shear stress.
|
22496787 |
2012 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast to the situation in humans, lpxL1 LPS has agonistic activity for cytokine production in peritoneal macrophages of DBA mice, and exacerbated arthritis in murine collagen induced arthritis model.
|
21088052 |
2011 |
|
Glaucoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we address this critical element in DBA/2J (D2) mice, an established model of chronic inherited glaucoma, using as a control the congenic substrain DBA/2J Gpnmb(+/SjJ) (D2G), which is not affected by glaucoma.
|
21246546 |
2011 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study was specifically designed to identify early stages of glaucoma in DBA/2J mice.
|
21383504 |
2011 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis.
|
18178865 |
2008 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBA/2J (D2) mice develop an age-related form of glaucoma.
|
16827931 |
2006 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To induce arthritis in mice, rYKL-39 (1, 10 or 50 g in Freund's incomplete adjuvant) was injected into the right footpad of mice from four different strains (BALB/c, DBA/1J, C57BL/6 and ICR).
|
12102470 |
2003 |
|
Glaucoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Despite the phenotypic similarity between the glaucoma in the DBA/2J mouse and human pigmentary glaucoma, the results of this study suggest that DNA sequence variants in the human TYRP1 gene are not associated with inherited pigmentary glaucoma in humans.
|
12011806 |
2002 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice.
|
10051620 |
1999 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To find an "unlimited" source of antigenic material (aggrecan) for arthritis induction in BALB/c mice; to analyze the specificities of immune reactions to aggrecan and type II collagen in 2 arthritis-susceptible murine strains, BALB/c mice for proteoglycan (aggrecan)-induced arthritis and DBA/1j mice for collagen-induced arthritis; to compare the histopathologic features of arthritis induced by purified aggrecans or total extracts of osteoarthritic (OA) cartilage; and to determine arthritis susceptibility in various BALB/c colonies.
|
9627010 |
1998 |
|
Anemia, Diamond-Blackfan
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
In addition, as excessive heme could amplify ribosomal protein imbalance, prematurely lower GATA1, and impede mitosis, these data may help explain the ineffective (early termination of) erythropoiesis in Diamond Blackfan anemia and del(5q) myelodysplasia, disorders with excessive heme in colony-forming unit-erythroid/proerythroblasts, explain why these anemias are macrocytic, and show why children with GATA1 mutations have DBA-like clinical phenotypes.
|
30530752 |
2019 |
|
Anemia, Diamond-Blackfan
|
0.050 |
Biomarker
|
disease |
BEFREE |
Hazard ratios for these lectins were (+1 SD for the glycan index) as follows: SNA (recognizing glycan Siaα2-6Gal/GalNAc), 1.42 (95% CI 1.14-1.76); RCA120 (Galβ4GlcNAc), 1.28 (1.01-1.64); DBA (GalNAcα3GalNAc), 0.80 (0.64-0.997); ABA (Galβ3GalNAc), 1.29 (1.02-1.64); Jacalin (Galβ3GalNAc), 1.30 (1.02-1.67); and ACA (Galβ3GalNAc), 1.32 (1.04-1.67).
|
29930140 |
2018 |