Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.010 AlteredExpression disease BEFREE Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease. 28186506 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.010 Biomarker group BEFREE Inhibiting HDAC1 Enhances the Anti-Cancer Effects of Statins through Downregulation of GGTase-Iβ Expression. 28481295 2018
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.010 Biomarker disease BEFREE HDAC1 links early life stress to schizophrenia-like phenotypes. 28533418 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.010 Biomarker group BEFREE Inhibiting HDAC1 Enhances the Anti-Cancer Effects of Statins through Downregulation of GGTase-Iβ Expression. 28481295 2018
CUI: C0003864
Disease: Arthritis
Arthritis
0.010 Biomarker disease BEFREE In this study, we have investigated the role of histone deacetylase (HDAC) enzymes in RA synovial fibroblasts (RASFs), a key cellular mediator of cartilage and bone destruction and determined effects of HDAC1 inhibition on both RASF phenotype in vitro, and joint inflammation and damage in the collagen-induced arthritis (CIA) model. 26152200 2016
CUI: C0007138
Disease: Carcinoma, Transitional Cell
Carcinoma, Transitional Cell
0.010 Biomarker disease BEFREE Regardless, combined inhibition of HDAC1/2 appears to represent a promising strategy for urothelial carcinoma therapy.Mol Cancer Ther; 15(2); 299-312.©2016 AACR. 26772204 2016
CUI: C0021400
Disease: Influenza
Influenza
0.010 Biomarker disease BEFREE Influenza A Virus Dysregulates Host Histone Deacetylase 1 That Inhibits Viral Infection in Lung Epithelial Cells. 26912629 2016
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.010 AlteredExpression disease BEFREE The levels of HDAC1 and thioredoxin1 are related to the death of mesothelioma cells by suberoylanilide hydroxamic acid. 26936390 2016
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.010 Biomarker disease BEFREE Crosstalk between ATF4 and MTA1/HDAC1 promotes osteosarcoma progression. 26797758 2016
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.010 Biomarker disease BEFREE A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson's disease. 26545632 2016
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.010 Biomarker group BEFREE Influenza A Virus Dysregulates Host Histone Deacetylase 1 That Inhibits Viral Infection in Lung Epithelial Cells. 26912629 2016
CUI: C0152031
Disease: Joint swelling
Joint swelling
0.010 Biomarker phenotype BEFREE Furthermore, inhibition of HDAC1 in CIA resulted in reduced joint swelling, cartilage and bone damage and lower tumor necrosis factor in joint tissue. 26152200 2016
CUI: C0238790
Disease: bone destruction
bone destruction
0.010 Biomarker disease BEFREE In this study, we have investigated the role of histone deacetylase (HDAC) enzymes in RA synovial fibroblasts (RASFs), a key cellular mediator of cartilage and bone destruction and determined effects of HDAC1 inhibition on both RASF phenotype in vitro, and joint inflammation and damage in the collagen-induced arthritis (CIA) model. 26152200 2016
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.010 Biomarker disease BEFREE Crosstalk between ATF4 and MTA1/HDAC1 promotes osteosarcoma progression. 26797758 2016
Precursor B-cell lymphoblastic leukemia
0.010 Biomarker disease BEFREE Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia. 26655717 2016
CUI: C2145472
Disease: Urothelial Carcinoma
Urothelial Carcinoma
0.010 Biomarker disease BEFREE Regardless, combined inhibition of HDAC1/2 appears to represent a promising strategy for urothelial carcinoma therapy.Mol Cancer Ther; 15(2); 299-312.©2016 AACR. 26772204 2016
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma
0.010 Biomarker disease BEFREE We found that inhibition of class I HDACs, particularly HDAC-1, -2 and -3, was sufficient to induce EBV lytic cycle in NPC and GC cells in vitro and in vivo. 26205347 2016
CUI: C3539878
Disease: Triple Negative Breast Neoplasms
Triple Negative Breast Neoplasms
0.010 AlteredExpression disease BEFREE Here, we compare the activity of the pan-HDAC inhibitor suberoylanilide hydroxamic acid (SAHA), the class I/IIa HDAC inhibitor valproic acid (VPA), and the HDAC1/2-specific inhibitor romidepsin (ROMI) for their capability to regulate DNA damage repair gene expression and in sensitizing TNBC to PARPi. 26294743 2016
CUI: C0023470
Disease: Myeloid Leukemia
Myeloid Leukemia
0.010 Biomarker disease BEFREE HDAC1 and Klf4 interplay critically regulates human myeloid leukemia cell proliferation. 25341045 2015
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.010 Biomarker group BEFREE Collectively, these results demonstrate that NCX1 expression is regulated by the Sp3/REST/HDAC1/HDAC2 complex in tMCAO and by the Sp1/HIF-1/p300 complex in PC+tMCAO and that epigenetic intervention, by modulating the acetylation of ncx1-Br, may be a strategy for the development of innovative therapeutic intervention in stroke. 25972164 2015
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic
0.010 AlteredExpression disease BEFREE The expression of HDAC1,2,3,4,7 and Nur77 increased in PA samples at levels significantly higher than those observed in the CP group (p = 0.0160; 0.0114; 0.0227; 0.0440; 0.0136; 0.0004, respectively). 25275504 2015
CUI: C0278883
Disease: Metastatic melanoma
Metastatic melanoma
0.010 AlteredExpression disease BEFREE Eradication of metastatic melanoma through cooperative expression of RNA-based HDAC1 inhibitor and p73 by oncolytic adenovirus. 25071017 2015
CUI: C0007133
Disease: Carcinoma, Papillary
Carcinoma, Papillary
0.010 Biomarker disease BEFREE The cellular pattern of HDAC-1 and HDAC-2 distribution (nuclear vs. nuclear and cytoplasmic) presented a distinct discrimination between malignant and benign thyroid lesions (p = 0.0030 and p = 0.0028, respectively) as well as between papillary carcinoma and hyperplastic nodules (p = 0.0036 and p = 0.0028, respectively). 23873102 2014
Congenital ocular coloboma (disorder)
0.010 Biomarker disease BEFREE Furthermore, our data demonstrate that Bcl6a functions cooperatively with Bcor, Rnf2 and Hdac1 in a common gene regulatory network that acts to repress p53 and prevent colobomata. 23669349 2014
CUI: C0233794
Disease: Memory impairment
Memory impairment
0.010 AlteredExpression phenotype BEFREE Valproic acid is able to attenuate the prenatal hypoxia-induced Aβ neuropathology and learning and memory deficits via inhibiting the activation of histone deacetylase 1 (HDAC1), preventing the decrease in H3-Ace in the NEP promoter regions and reducing the down-regulation of NEP. 24289518 2014