Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0950123
Disease: Genetic Diseases, Inborn
Genetic Diseases, Inborn
0.100 GeneticVariation group CLINVAR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.020 AlteredExpression phenotype BEFREE (1)H-HRMAS technology revealed metabolomically distinct groups according to the expression of HDAC1, HDAC4 and SIRT1, suggesting that these genes may play an important role in regulating brain tumorigenesis and cancer progression. 25791281 2015
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.020 AlteredExpression disease BEFREE Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells. 18264140 2008
CUI: C0021400
Disease: Influenza
Influenza
0.010 Biomarker disease BEFREE Influenza A Virus Dysregulates Host Histone Deacetylase 1 That Inhibits Viral Infection in Lung Epithelial Cells. 26912629 2016
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.050 AlteredExpression disease BEFREE Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line. 13679859 2003
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.050 AlteredExpression disease BEFREE Histone deacetylase 1 mRNA expression in lung cancer. 15474665 2005
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.050 AlteredExpression disease BEFREE Histone deacetylase 1 mRNA expression in lung cancer. 15474665 2005
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.040 AlteredExpression disease BEFREE Histone deacetylase 1 mRNA expression in lung cancer. 15474665 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.040 AlteredExpression group BEFREE Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide. 17623797 2007
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.040 AlteredExpression disease BEFREE Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide. 17623797 2007
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.030 AlteredExpression disease BEFREE HDAC1 and HDAC3 are up-regulated in colon cancer cells and in primary colon cancer, and siRNA (small interfering RNA)-mediated silencing of HDAC1 and HDAC3 in colon cancer cells induces apoptosis. 18789002 2009
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.020 AlteredExpression disease BEFREE HDAC1 and HDAC3 are up-regulated in colon cancer cells and in primary colon cancer, and siRNA (small interfering RNA)-mediated silencing of HDAC1 and HDAC3 in colon cancer cells induces apoptosis. 18789002 2009
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.040 AlteredExpression disease BEFREE HDAC1 overexpression conferred resistance to bortezomib in MM cells, and administration of the HDAC inhibitor romidepsin restored sensitivity to bortezomib in HDAC1-overexpressing cells both in vitro and in vivo. 20351311 2010
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.020 AlteredExpression disease BEFREE HDAC1 and HDAC4 showed high expression in T-ALL and HDAC5 was highly expressed in B-lineage ALL. 20636436 2010
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.310 AlteredExpression disease BEFREE HDAC1 and HDAC2 are differentially expressed in endometriosis. 22344732 2012
Liver and Intrahepatic Biliary Tract Carcinoma
0.020 AlteredExpression disease BEFREE HDAC1 inactivation induces mitotic defect and caspase-independent autophagic cell death in liver cancer. 22496786 2012
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.020 AlteredExpression disease BEFREE HDAC1 inactivation induces mitotic defect and caspase-independent autophagic cell death in liver cancer. 22496786 2012
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease BEFREE HDAC1-3 were up-regulated in HCC samples from patients. 22641068 2012
Idiopathic pulmonary arterial hypertension
0.300 Biomarker disease CTD_human HDAC1 and HDAC5 protein levels were elevated in lungs from human idiopathic pulmonary arterial hypertension and in lungs and right ventricles from rats exposed to hypoxia. 22711276 2012
CUI: C0269102
Disease: Endometrioma
Endometrioma
0.310 AlteredExpression disease BEFREE Histone deacetylase-1 target mRNAs that were up-regulated by valproic acid (VPA) treatment in endometriotic cyst stromal cells (ECSCs) were identified by a global mRNA microarray technique. 23833041 2013
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.040 AlteredExpression disease BEFREE HDAC1 overexpression ameliorates the cytotoxic effect of K-7174 and abrogates histone hyperacetylation without affecting the accumulation of ubiquitinated proteins in K-7174-treated myeloma cells. 23878197 2013
Leukocyte adhesion deficiency type 1
0.020 AlteredExpression disease BEFREE HDAC1/4 levels in docetaxel-insensitive human LAD tissues, inversely correlated with miR-200b, were upregulated compared with docetaxel-sensitive tissues. 24830600 2015
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.030 Biomarker disease BEFREE Histone deacetylase 1/Sp1/microRNA-200b signaling accounts for maintenance of cancer stem-like cells in human lung adenocarcinoma. 25279705 2016
CUI: C0023470
Disease: Myeloid Leukemia
Myeloid Leukemia
0.010 Biomarker disease BEFREE HDAC1 and Klf4 interplay critically regulates human myeloid leukemia cell proliferation. 25341045 2015
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.060 AlteredExpression disease BEFREE HDAC1 overexpression independently predicts biochemical recurrence and is associated with rapid tumor cell proliferation and genomic instability in prostate cancer. 25794974 2015