Embryonal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
This holds true also in testicular tumors, where HDAC1 has been demonstrated in embryonal carcinoma, seminoma and teratoma.
|
16960727 |
2007 |
Squamous cell carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma.
|
21527555 |
2011 |
Endometriosis
|
0.310 |
Biomarker
|
disease |
CTD_human |
Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis.
|
22138541 |
2012 |
Endometrioma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis.
|
22138541 |
2012 |
MYELODYSPLASTIC SYNDROME
|
0.310 |
Biomarker
|
group |
CTD_human |
Apoptotic cells significantly increased in both types of MDS. mRNA and protein levels of HDAC1 and TLR2 were reduced, whereas GATA-1 was increased in both types of MDS.
|
28963909 |
2017 |
Heart Diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy.
|
18625706 |
2008 |
Familial primary pulmonary hypertension
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
|
22711276 |
2012 |
PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
|
22711276 |
2012 |
Pulmonary Hypertension, Primary, Fenfluramine-Associated
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
|
22711276 |
2012 |
Hematopoetic Myelodysplasia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Effects of arsenic disulfide on apoptosis, histone acetylation, toll like receptor 2 activation, and erythropoiesis in bone marrow mononuclear cells of myelodysplastic syndromes patients in vitro.
|
28963909 |
2017 |
Idiopathic pulmonary arterial hypertension
|
0.300 |
Biomarker
|
disease |
CTD_human |
HDAC1 and HDAC5 protein levels were elevated in lungs from human idiopathic pulmonary arterial hypertension and in lungs and right ventricles from rats exposed to hypoxia.
|
22711276 |
2012 |
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
|
22711276 |
2012 |
Pulmonary Hypertension, Primary, 1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
|
22711276 |
2012 |
Schizophrenia
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels.
|
17961987 |
2008 |
Schizophrenia
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
In summary, we suggest that reduced p35 expression in schizophrenia has an impact on synaptic protein expression and cognition and that these deficits can be rescued, at least in part, by the inhibition of histone deacetylase 1.
|
21772061 |
2011 |
Schizophrenia
|
0.360 |
Biomarker
|
disease |
BEFREE |
Our data suggest that HDAC1 inhibition should be considered as a therapeutic approach to treat schizophrenia.
|
28533418 |
2017 |
Schizophrenia
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
We used >700 well-characterized samples from patients diagnosed with schizophrenia (n = 175), major depressive disorder (n = 135), and bipolar disorder (n = 61) to measure HDAC1 and HDAC2 transcript levels by quantitative real-time PCR in dorsolateral prefrontal cortex (DLPFC) and caudate compared to control samples.
|
27959513 |
2017 |
Schizophrenia
|
0.360 |
Biomarker
|
disease |
BEFREE |
To characterize the contribution of these factors to the developmental perturbation hypothesized to underlie SZ, lentiviral vectors carrying short hairpin RNA interference (shRNAi) for HDAC1 and DAXX were used.
|
26812044 |
2016 |
Schizophrenia
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
Several of the genes in this network including epigenetic factors histone deacetylase 1 (HDAC1) and death-associated protein 6 (DAXX), the GABAergic enzyme GAD65 as well as the kainate receptor (KAR) subunits GluR6 and 7 show significant changes in expression in this area in SZ.
|
27733539 |
2017 |
Squamous cell carcinoma
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma.
|
21527555 |
2011 |
Endometriosis
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
HDAC1 and HDAC2 are differentially expressed in endometriosis.
|
22344732 |
2012 |
Endometrioma
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Histone deacetylase-1 target mRNAs that were up-regulated by valproic acid (VPA) treatment in endometriotic cyst stromal cells (ECSCs) were identified by a global mRNA microarray technique.
|
23833041 |
2013 |
MYELODYSPLASTIC SYNDROME
|
0.310 |
AlteredExpression
|
group |
BEFREE |
Apoptotic cells significantly increased in both types of MDS. mRNA and protein levels of HDAC1 and TLR2 were reduced, whereas GATA-1 was increased in both types of MDS.
|
28963909 |
2017 |
Cerebrovascular accident
|
0.210 |
Biomarker
|
group |
BEFREE |
Collectively, these results demonstrate that NCX1 expression is regulated by the Sp3/REST/HDAC1/HDAC2 complex in tMCAO and by the Sp1/HIF-1/p300 complex in PC+tMCAO and that epigenetic intervention, by modulating the acetylation of ncx1-Br, may be a strategy for the development of innovative therapeutic intervention in stroke.
|
25972164 |
2015 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hypermethylation of APC, HDAC1, and GSK1 genes has been previously reported in more than one study on tissue samples of breast cancer.
|
28349825 |
2017 |