SLC6A4, solute carrier family 6 member 4, 6532

N. diseases: 440; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease BEFREE Despite its functional role, results highlight the usefulness of 5HTT as a valuable tracer of SIDS risk in IALTE infants. 22711722 2012
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease BEFREE This article indicates that neither the VNTR in the promoter of the MAOA gene, nor rs25531 in the gene encoding 5-HTT, is involved in SIDS. 24286237 2014
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease BEFREE In our recent study allele variants in the promoter of serotonin transporter (5-HTT) gene have been shown as a novel risk factor for sudden infant death syndrome (SIDS). 12018976 2002
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease BEFREE Findings are discussed considering the metabolic association among DAT, 5-HTT and MAOA with special emphasis on the linked action of 5-HTT/MAOA in regulating serotonin metabolism of SIDS and SIUD infants. 18810510 2009
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease CTD_human These results indicate a relationship between SIDS and the L allele of the 5-HTT gene in African Americans and Caucasians, and if confirmed, will provide an important tool for identifying at-risk individuals and estimating the risk of recurrence. 12599191 2003
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease LHGDN Polymorphisms in the promoter of the 5-HTT gene may be of importance with regard to SIDS. 18477062 2008
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 AlteredExpression disease BEFREE Using qRT-PCR we studied the gene expression of 5-HTT in ten SIDS cases, previously analyzed at a molecular level and which showed the genetic S/S profile. 22771822 2013
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease LHGDN Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome. 18387780 2008
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease BEFREE 5-HT neuron count and density, 5-HT(1A) receptor binding density, and 5-HT transporter (5-HTT) binding density in the medullary 5-HT system; correlation between these markers and 6 recognized risk factors for SIDS. 17077377 2006
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease BEFREE Polymorphisms in the promoter of the 5-HTT gene may be of importance with regard to SIDS. 18477062 2008
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease BEFREE One of the candidate genes is the serotonin transporter (5-HTT) gene, based on decreased serotonergic receptor binding observed in the brain-stems of SIDS victims. 19261524 2009
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease BEFREE Therefore, we aimed to identify the possibility that specific allele variants of the 5-HTT gene can be found as a genetic background for sudden infant death syndrome (SIDS). 11335745 2001
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease LHGDN 3' UTR polymorphism of the serotonin transporter gene and sudden infant death syndrome: haplotype analysis. 16691588 2006
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease MGD Overall, our findings provide i) new insights into the role of SERT gene in SIDS, and ii) the first in vivo validation of the molecular mechanism involving the activation of TGF-beta1 signalling in the cardiac fibrosis. 19646988 2009
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 AlteredExpression disease BEFREE These data, if confirmed in larger studies, may begin to explain the differences in SIDS incidence by ethnicity, suggest a role for levels of 5-HTT expression in generation of SIDS susceptibility, and provide an important tool for identifying at-risk individuals and estimating the risk of recurrence. 12966525 2003
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease GENOMICS_ENGLAND These results indicate a relationship between SIDS and the 12-repeat allele of the intron 2 variable number tandem repeat of the 5-HTT gene in African-Americans, and a significant role of the haplotype containing the 12-repeat allele and the promoter L-allele in defining SIDS risk in African-Americans. 12966525 2003
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease BEFREE These results indicate a relationship between SIDS and the L allele of the 5-HTT gene in African Americans and Caucasians, and if confirmed, will provide an important tool for identifying at-risk individuals and estimating the risk of recurrence. 12599191 2003
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease LHGDN These results indicate a relationship between SIDS and the 12-repeat allele of the intron 2 variable number tandem repeat of the 5-HTT gene in African-Americans, and a significant role of the haplotype containing the 12-repeat allele and the promoter L-allele in defining SIDS risk in African-Americans. 12966525 2003
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease BEFREE These observations do not support previous findings that the L allele and/or LL genotype of the 5-HTTLPR are associated with SIDS. 20661167 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 GeneticVariation disease BEFREE Additionally, to elucidate pathophysiological mechanisms that could explain the relations between MUPS and depression, we investigate the association between a sustained high level of MUPS, and (I) omega (ω)-3 and -6 fatty acid (FA)-status and (II) functional polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR). 22100130 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease BEFREE Antidepressants that block the serotonin transporter, (Slc6a4/SERT), selective serotonin reuptake inhibitors (SSRIs) improve mood in adults but have paradoxical long-term effects when administered during perinatal periods, increasing the risk to develop anxiety and depression. 30279456 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 GeneticVariation disease BEFREE A deletion/insertion polymorphism within the 5-HT transporter promoter gene (5-HTTLPR) is thought to be associated with disturbed impulse control, anxiety, and depression. 20010449 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 GeneticVariation disease BEFREE A common regulatory variant (5-HTTLPR) in the human serotonin transporter gene (SLC6A4), resulting in altered transcription and transporter availability, has been associated with vulnerability for affective disorders, including anxiety and depression. 15699291 2005
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease BEFREE We test associations between 5-HTTLPR and (1) behavioral traits and (2) clinical diagnoses of anxiety and depression. 28391138 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 GeneticVariation disease BEFREE Seasonal variations in mood and behavior (seasonality) and seasonal affective disorder (SAD) have been attributed to seasonal fluctuations in brain serotonin (5-HT). the short (s), as opposed to the long (l), allele of the 5-HT transporter linked polymorphism (5-HTTLPR) has been associated with neuroticism and depression. 9577843 1998