Depressive disorder
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
Anxiety
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
Autism Spectrum Disorders
|
0.300 |
Biomarker
|
disease |
MGD |
|
|
|
Compulsive hoarding
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Skin-picking
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
OBSESSIVE-COMPULSIVE DISORDER, SUSCEPTIBILITY TO
|
0.100 |
SusceptibilityMutation
|
phenotype |
CLINVAR |
|
|
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results provide preliminary evidence that alterations in the primary structure of 5-HTT are not generally involved in the pathogenesis of unipolar depression and manic-depressive illness.
|
7711157 |
1995 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results provide preliminary evidence that alterations in the primary structure of 5-HTT are not generally involved in the pathogenesis of unipolar depression and manic-depressive illness.
|
7711157 |
1995 |
MAJOR AFFECTIVE DISORDER 2
|
0.080 |
Biomarker
|
disease |
BEFREE |
The results provide preliminary evidence that alterations in the primary structure of 5-HTT are not generally involved in the pathogenesis of unipolar depression and manic-depressive illness.
|
7711157 |
1995 |
Mood Disorders
|
0.600 |
AlteredExpression
|
group |
BEFREE |
If this finding is replicated, further work on genetic variants with low 5-HTT activity may facilitate the differential diagnosis of affective disorders, the assessment of suicidal behaviour, and the prediction of good clinical response to antidepressants.
|
9154246 |
1996 |
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in the serotonin transporter gene (5HTT) have been reported to be associated with neuroticism (emotionality) and with depression.
|
9175133 |
1997 |
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The latter polymorphism alters transcriptional activity of SLC6A4, and has been reported to be associated with anxiety and depression-related traits.
|
9402979 |
1997 |
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5-HTR2c) and serotonin transporter (5-HTT) genes.
|
9342201 |
1997 |
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT).
|
9322234 |
1997 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in the serotonin transporter gene (5HTT) have been reported to be associated with neuroticism (emotionality) and with depression.
|
9175133 |
1997 |
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The successful use of SRIs in OCD has led to the hypothesis that 5-HTT may play a pivotal role in the pathogenesis of OCD.
|
9322235 |
1997 |
Anxiety
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The latter polymorphism alters transcriptional activity of SLC6A4, and has been reported to be associated with anxiety and depression-related traits.
|
9402979 |
1997 |
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
Evidence of linkage between the serotonin transporter and autistic disorder.
|
9152989 |
1997 |
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Overall, we were not able to replicate the findings of the first study on 5-HTT and autism and instead observed a tendency for association of the opposite genetic variant of the gene with the disorder.
|
9361027 |
1997 |
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Polymorphisms in the serotonin transporter gene (5HTT) have been reported to be associated with neuroticism (emotionality) and with depression.
|
9175133 |
1997 |
Withdrawal Symptoms
|
0.320 |
GeneticVariation
|
phenotype |
BEFREE |
The present study tested the hypothesis that the short, low activity variant of a biallelic polymorphism in the 5' regulatory region of the human serotonin transporter (5-HTT) gene confers susceptibility to severe alcohol dependence marked by severe withdrawal symptoms.
|
9394104 |
1997 |
NEUROTICISM
|
0.100 |
Biomarker
|
disease |
BEFREE |
A recent report of an association between 5HTT and neuroticism involved unselected samples and self-report questionnaires.
|
9175133 |
1997 |
Severe alcohol dependence
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The present study tested the hypothesis that the short, low activity variant of a biallelic polymorphism in the 5' regulatory region of the human serotonin transporter (5-HTT) gene confers susceptibility to severe alcohol dependence marked by severe withdrawal symptoms.
|
9394104 |
1997 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Seasonal variations in mood and behavior (seasonality) and seasonal affective disorder (SAD) have been attributed to seasonal fluctuations in brain serotonin (5-HT). the short (s), as opposed to the long (l), allele of the 5-HT transporter linked polymorphism (5-HTTLPR) has been associated with neuroticism and depression.
|
9577843 |
1998 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Thus, our data do not support the association between depressive disorder and a nine-repeat allelic variant of the 5-HTT VNTR marker recently reported by Ogilvie et al.(Lancet 347:731-733, 1996).
|
9514579 |
1998 |