SLC6A4, solute carrier family 6 member 4, 6532

N. diseases: 440; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease HPO
CUI: C0003467
Disease: Anxiety
Anxiety 		0.500 Biomarker disease HPO
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		0.300 Biomarker disease MGD
CUI: C0424290
Disease: Compulsive hoarding
Compulsive hoarding 		0.100 Biomarker disease HPO
CUI: C1696701
Disease: Skin-picking
Skin-picking 		0.100 Biomarker disease HPO
CUI: C4016373
Disease: OBSESSIVE-COMPULSIVE DISORDER, SUSCEPTIBILITY TO
OBSESSIVE-COMPULSIVE DISORDER, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 Biomarker disease BEFREE The results provide preliminary evidence that alterations in the primary structure of 5-HTT are not generally involved in the pathogenesis of unipolar depression and manic-depressive illness. 7711157 1995
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.600 Biomarker disease BEFREE The results provide preliminary evidence that alterations in the primary structure of 5-HTT are not generally involved in the pathogenesis of unipolar depression and manic-depressive illness. 7711157 1995
CUI: C1839839
Disease: MAJOR AFFECTIVE DISORDER 2
MAJOR AFFECTIVE DISORDER 2 		0.080 Biomarker disease BEFREE The results provide preliminary evidence that alterations in the primary structure of 5-HTT are not generally involved in the pathogenesis of unipolar depression and manic-depressive illness. 7711157 1995
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.400 Biomarker disease CTD_human Evidence of linkage between the serotonin transporter and autistic disorder. 9152989 1997
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.600 AlteredExpression group BEFREE If this finding is replicated, further work on genetic variants with low 5-HTT activity may facilitate the differential diagnosis of affective disorders, the assessment of suicidal behaviour, and the prediction of good clinical response to antidepressants. 9154246 1996
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease BEFREE Polymorphisms in the serotonin transporter gene (5HTT) have been reported to be associated with neuroticism (emotionality) and with depression. 9175133 1997
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease BEFREE Polymorphisms in the serotonin transporter gene (5HTT) have been reported to be associated with neuroticism (emotionality) and with depression. 9175133 1997
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 Biomarker phenotype BEFREE Polymorphisms in the serotonin transporter gene (5HTT) have been reported to be associated with neuroticism (emotionality) and with depression. 9175133 1997
CUI: C1842981
Disease: NEUROTICISM
NEUROTICISM 		0.100 Biomarker disease BEFREE A recent report of an association between 5HTT and neuroticism involved unselected samples and self-report questionnaires. 9175133 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 GeneticVariation disease BEFREE Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT). 9322234 1997
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.600 Biomarker disease BEFREE The successful use of SRIs in OCD has led to the hypothesis that 5-HTT may play a pivotal role in the pathogenesis of OCD. 9322235 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 GeneticVariation disease BEFREE We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5-HTR2c) and serotonin transporter (5-HTT) genes. 9342201 1997
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.400 Biomarker disease BEFREE Overall, we were not able to replicate the findings of the first study on 5-HTT and autism and instead observed a tendency for association of the opposite genetic variant of the gene with the disorder. 9361027 1997
CUI: C0087169
Disease: Withdrawal Symptoms
Withdrawal Symptoms 		0.320 GeneticVariation phenotype BEFREE The present study tested the hypothesis that the short, low activity variant of a biallelic polymorphism in the 5' regulatory region of the human serotonin transporter (5-HTT) gene confers susceptibility to severe alcohol dependence marked by severe withdrawal symptoms. 9394104 1997
CUI: C4075720
Disease: Severe alcohol dependence
Severe alcohol dependence 		0.010 GeneticVariation disease BEFREE The present study tested the hypothesis that the short, low activity variant of a biallelic polymorphism in the 5' regulatory region of the human serotonin transporter (5-HTT) gene confers susceptibility to severe alcohol dependence marked by severe withdrawal symptoms. 9394104 1997
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.600 GeneticVariation group BEFREE There is some evidence suggesting that a polymorphism of variable number of tandem repeats (VNTR) in the second intron of the serotonin transporter (5-HTT) gene and another variation which lies 1.2 kb upstream of the promoter of the gene (5-HTTLPR) are associated with affective disorders. 9399688 1998
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.600 GeneticVariation group BEFREE The latter polymorphism alters transcriptional activity of SLC6A4, and has been reported to be associated with anxiety and depression-related traits. 9402979 1997
CUI: C0003467
Disease: Anxiety
Anxiety 		0.500 GeneticVariation disease BEFREE The latter polymorphism alters transcriptional activity of SLC6A4, and has been reported to be associated with anxiety and depression-related traits. 9402979 1997
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 GeneticVariation disease BEFREE Thus, our data do not support the association between depressive disorder and a nine-repeat allelic variant of the 5-HTT VNTR marker recently reported by Ogilvie et al.(Lancet 347:731-733, 1996). 9514579 1998