Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This article indicates that neither the VNTR in the promoter of the MAOA gene, nor rs25531 in the gene encoding 5-HTT, is involved in SIDS.
|
24286237 |
2014 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In our recent study allele variants in the promoter of serotonin transporter (5-HTT) gene have been shown as a novel risk factor for sudden infant death syndrome (SIDS).
|
12018976 |
2002 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms in the promoter of the 5-HTT gene may be of importance with regard to SIDS.
|
18477062 |
2008 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the promoter of the 5-HTT gene may be of importance with regard to SIDS.
|
18477062 |
2008 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we aimed to identify the possibility that specific allele variants of the 5-HTT gene can be found as a genetic background for sudden infant death syndrome (SIDS).
|
11335745 |
2001 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
3' UTR polymorphism of the serotonin transporter gene and sudden infant death syndrome: haplotype analysis.
|
16691588 |
2006 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
These results indicate a relationship between SIDS and the L allele of the 5-HTT gene in African Americans and Caucasians, and if confirmed, will provide an important tool for identifying at-risk individuals and estimating the risk of recurrence.
|
12599191 |
2003 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
These results indicate a relationship between SIDS and the 12-repeat allele of the intron 2 variable number tandem repeat of the 5-HTT gene in African-Americans, and a significant role of the haplotype containing the 12-repeat allele and the promoter L-allele in defining SIDS risk in African-Americans.
|
12966525 |
2003 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
These observations do not support previous findings that the L allele and/or LL genotype of the 5-HTTLPR are associated with SIDS.
|
20661167 |
2010 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Additionally, to elucidate pathophysiological mechanisms that could explain the relations between MUPS and depression, we investigate the association between a sustained high level of MUPS, and (I) omega (ω)-3 and -6 fatty acid (FA)-status and (II) functional polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR).
|
22100130 |
2012 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A deletion/insertion polymorphism within the 5-HT transporter promoter gene (5-HTTLPR) is thought to be associated with disturbed impulse control, anxiety, and depression.
|
20010449 |
2010 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A common regulatory variant (5-HTTLPR) in the human serotonin transporter gene (SLC6A4), resulting in altered transcription and transporter availability, has been associated with vulnerability for affective disorders, including anxiety and depression.
|
15699291 |
2005 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Seasonal variations in mood and behavior (seasonality) and seasonal affective disorder (SAD) have been attributed to seasonal fluctuations in brain serotonin (5-HT). the short (s), as opposed to the long (l), allele of the 5-HT transporter linked polymorphism (5-HTTLPR) has been associated with neuroticism and depression.
|
9577843 |
1998 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In those with depression, the short allele of 5-HTT was associated with smaller caudate nucleus volumes.
|
16930719 |
2007 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Since both posttraumatic stress disorder (PTSD) and depression are associated with disturbances in the serotoninergic system, the aim of the study was to determine the association between severity of PTSD symptoms, serotonin transporter polymorphism (5-HTTLPR) and platelet serotonin (5-HT) concentration, in male combat veterans with PTSD (n = 325), who were subdivided according to presence of comorbid depression.
|
27525827 |
2016 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A number of studies have shown that the presence of short (S) allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) is associated with a higher risk for depression following exposure to stressful life events.
|
29129791 |
2018 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The NET and 5-HT1A polymorphisms appear to have similar effects on hippocampal volume in patients and controls while the 5-HTTLPR polymorphism differentially affects hippocampal volume in the presence of depression.
|
25990886 |
2015 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Individualization of therapy for depression may be achieved through consideration of the specific associations that patients exhibit between life stress, 5-HTTLPR polymorphism, and depression symptomatology.
|
30127611 |
2018 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Participants who were homozygous for the short allele of 5-HTTLPR or carried a STin2.9 VNTR allele were significantly more likely to have a history of depression.
|
17909168 |
2007 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The 5-HTTLPR short allele (s) has been associated with anxiety-related personality traits and depression, and one study observed an association between the 5-HTTLPR s-allele and SAD and the trait of seasonality.
|
14593433 |
2003 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A case-control and family-based association study of the 5-HTTLPR in pediatric-onset depressive disorders.
|
15312818 |
2004 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The findings indicate that ELBW/SGAs carrying the 5-HTTLPR short allele reported increased internalizing problems, particularly depression, during the third and fourth decades of life.
|
27416920 |
2017 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Depression symptoms increased during antiviral treatment; 5-HTTLPR genotype moderated IFN-alpha-induced depression symptoms in both non-Hispanic Caucasians and Hispanic patients, although the opposite risk allele was associated with depression in the two populations.
|
20332289 |
2010 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We recorded the symptomatic profile in 73 in panic disorder patients using observer-rated instruments (Panic Disorder Severity Scale, PDSS; Montgomery-Asberg Depression Rating Scale, MADRS) and hypothesized more severe symptoms in patients carrying the 5-HTTLPR s-allele.
|
19683026 |
2009 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Diabetic patients who had Beck Depression Inventory scores ≥ 14 had experienced significantly more different types of childhood trauma than those with Beck Depression Inventory scores < 14 (P < .001), independent of potential interaction with 5-HTTLPR genotype.
|
21034694 |
2011 |