|
Arthralgia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
In 5HTT, the rs1042173 was associated with painful TMD (arthralgia and myofascial pain) (OR<sub>c</sub> = 1.97; CI 95%: 1.02-3.77; P = 0.04).
|
30811655 |
2019 |
|
Fetal Growth Retardation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Although there was no significant change in TPH1 mRNA, the mRNA of TPH2 and SLC6A4 was significantly decreased in FGR placentae (p < 0.05), while 5-HT receptor mRNA was significantly increased in FGR compared with control (p < 0.01).
|
31176514 |
2019 |
|
Multiple Sclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found that the association between SLE load and MS depression severity was stronger among those with one or two copies of the short allele of the 5-HTTLPR.
|
29683385 |
2019 |
|
Temporomandibular Joint Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In 5HTT, the rs1042173 was associated with painful TMD (arthralgia and myofascial pain) (OR<sub>c</sub> = 1.97; CI 95%: 1.02-3.77; P = 0.04).
|
30811655 |
2019 |
|
Dissociation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
For boys, higher ASD traits were associated with the 5-HTTLPR LL genotype in combination with either a negative maternal appraisal of the flood, or high levels of maternal composite subjective stress, PSTD-like or peritraumatic dissociation symptoms.
|
30394245 |
2019 |
|
Linear atrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, we combined immunohistochemistry, high resolution confocal imaging, and 3D-reconstruction techniques to map and quantify the distribution of VGLUT3 immunoreactive boutons within 5-HT vs. SERT-positive axons in various regions of the mouse forebrain, including the prefrontal cortex, nucleus accumbens core and shell, bed nucleus of the stria terminalis, dorsal striatum, lateral septum, basolateral and central amygdala, and hippocampus.
|
31133811 |
2019 |
|
Malnutrition
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The opposite effects of 5-HTTLPR polymorphism on global network characteristics in the two groups suggest an interaction of the short allele and malnutrition in modulating brain network properties.
|
31680805 |
2019 |
|
Soft tissue rheumatism
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In 5HTT, the rs1042173 was associated with painful TMD (arthralgia and myofascial pain) (OR<sub>c</sub> = 1.97; CI 95%: 1.02-3.77; P = 0.04).
|
30811655 |
2019 |
|
psychosocial stressor
|
0.010 |
Biomarker
|
disease |
BEFREE |
The current candidate gene and environment interaction (cGxE) study examined whether the effects of an experimentally manipulated psychosocial stressor on self-reported drinking urge and implicit attentional bias for alcohol cues differ as a function of a cumulative genetic score of 5-HTTLPR, MAO-A, DRD4, DAT1 and DRD2 genotypes.
|
30192917 |
2019 |
|
Lewy Body Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We aimed to study degeneration of terminals with dopamine and serotonin transporter (DAT and SERT, respectively) in patients with early-stage PD and DLB relative to healthy controls, using <sup>123</sup>I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (<sup>123</sup>I-FP-CIT) single photon emission computed tomography (SPECT).
|
30884365 |
2019 |
|
Ischemic stroke
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SERT gene polymorphisms in 270 non-depressed first-ever acute ischemic stroke patients randomized to citalopram, n = 130, or placebo, n = 140, were investigated.
|
30844812 |
2019 |
|
Adrenal Gland Hyperfunction
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The following molecular candidates can help to differentiate PSD patients from non-depressed stroke subjects: decreased serum BDNF concentrations; increased early markers of inflammation (high-sensitivity C-reactive protein, ferritin, neopterin, and glutamate), serum pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-18, IFN-γ), as well as pro-inflammatory/anti-inflammatory ratios (TNF-α/IL-10, IL-1β/IL-10, IL-6/IL-10, IL-18/IL-10, IFN-γ/IL-10); lowered complement expression; decreased serum vitamin D levels; hypercortisolemia and blunted cortisol awakening response; S/S 5-HTTLPR, STin2 9/12, and 12/12 genotypes of the serotonin transporter gene SLC6A4, 5-HTR2a 1438 A/A, and BDNF met/met genotypes; higher SLC6A4 promoter and BDNF promoter methylation status.
|
30061860 |
2018 |
|
Behavior Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The human monoamine transporters (hMATs) primary including hSERT, hNET and hDAT are important targets for the treatment of depression and other behavioral disorders with more than availability of 30 approved drugs.
|
30306851 |
2018 |
|
Rectal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The SERT gene promoter SNP rs25531 was associated with the CRF in patients with colon and rectal cancer and the G genotype was an independent risk factor for CRF among individuals with colon and rectal cancer in the study.
|
29551185 |
2018 |
|
Crohn Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
STin2 VNTR polymorphism of SLC6A4 gene may contribute to CD pathogenesis.
|
30394015 |
2018 |
|
Globus Hystericus
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We investigated the association between the SLC6A4 polymorphism and globus pharyngeus and its response to treatment with antidepressants.
|
29310115 |
2018 |
|
Hamartoma Syndrome, Multiple
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To analyze the distribution of SLC6A4 gene polymorphisms in Crohn's disease (CD) patients and their association with the disease.
|
30394015 |
2018 |
|
Malignant Carcinoid Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
SERT inhibition by tramadol, tapentadol, methadone, dextromethorphan and pethidine may contribute to the serotonin syndrome.
|
29210063 |
2018 |
|
Prune Belly Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
At the first week, SERT protein levels were basically comparable in rats treated with undiluted LGG-s, double-diluted LGG-s, and triple-diluted LGG-s, which were higher than those in the control group and PBS-treated PI-IBS group.
|
29391756 |
2018 |
|
Emotional impulsivity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the link of s allele of 5-HTTLPR to emotional impulsivity was mediated by depressive symptoms, particularly perceptions of social rejection.
|
29090386 |
2018 |
|
Disorder of ejaculation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The innovative study design elaborates that androgen receptor trinucleotide repeats and 5-HTTLPR genotypes have combinatorial impact on hormonal milieu and sexual function regarding evidence-based lifelong premature ejaculatory dysfunction patients.
|
30019487 |
2018 |
|
Caffeine related disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
MDMA acts at dopamine (DA) transporter (DAT) and serotonin (5-HT) transporter (SERT) and is known to induce damage of dopamine and serotonin neurons.MDMA is often ingested with caffeine.
|
29134560 |
2018 |
|
Harlequin Fetus
|
0.010 |
Biomarker
|
disease |
BEFREE |
In two large community samples, the moderating role of 5-HTTLPR was examined related to more hyperactivity-impulsivity symptoms (HI symptoms) predicted by more peer problems.
|
28295205 |
2018 |
|
Painful Bladder Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
At the first week, SERT protein levels were basically comparable in rats treated with undiluted LGG-s, double-diluted LGG-s, and triple-diluted LGG-s, which were higher than those in the control group and PBS-treated PI-IBS group.
|
29391756 |
2018 |
|
Intestinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Alterations in 5-HT transmission have been linked to pathological symptoms in both intestinal and psychiatric disorders and selective 5-HT transporter (5-HTT) inhibitors, affecting the 5-HT system by blocking the 5-HT transporter (5-HTT) have been successfully used to treat CNS- and intestinal disorders.
|
28824378 |
2017 |