|
Abdominal Pain
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The frequency of SLC6A4-polymorphism and higher levels of 5-HT were significantly associated with IBS, particularly in patients with diarrhea and abdominal pain, suggesting that SLC6A4 is a potential candidate gene involved in the pathogenesis of IBS.
|
22457857 |
2012 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Nevertheless, research preliminarily indicates a methylation-driven increased vulnerability of carriers of the short allele of 5-HTTLPR to psychiatric disorders when exposed to early stress or soon after exposure to stress.
|
27880876 |
2017 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Though these analogs are not superior than D22 in discriminating among OCTs/PMAT, our findings point to development of compounds with combined ability to inhibit both low-affinity/high-capacity transporters, such as OCT3, and high-affinity/low-capacity transporters, such as SERT, as therapeutics with potentially improved efficacy for treatment of psychiatric disorders.
|
30473490 |
2019 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Since the 5-HT transporter plays an important role in regulation of 5-HT transmission, its gene can be considered as a candidate for vulnerability to psychiatric disorders.
|
10673774 |
2000 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Previous studies have showed associations of serotonin transporter (5-HTT) and monoamine oxidase A (MAOA) with behavioral and psychiatric disorders.
|
30126429 |
2018 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We have recently described a polymorphism in the 5-HTT gene promoter (5-HTTLPR) which influences the function of the 5-HTT and is associated with several psychiatric disorders.
|
10676853 |
2000 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The serotonin transporter promoter length polymorphism (5-hydroxytryptamine transporter length polymorphism; 5-HTTLPR) has long been implicated in autism and other psychiatric disorders.
|
20649385 |
2010 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
It was demonstrated that polymorphisms in the promoter region (5-HTTLPR) and in the second intron (VNTR) have functional consequences and are for this reason of particular interest in relation to various psychiatric disorders.
|
16969272 |
2006 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The most common of these variants, SERT Ala56, located in the transporter's cytosolic N-terminus, has been found to confer in transgenic mice hyperserotonemia, an ASD-associated biochemical trait, an elevated brain 5-HT clearance rate, and ASD-aligned behavioral changes.
|
30668912 |
2019 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
A functional polymorphism (5-HTTLPR) in the upstream regulatory region of the gene (SLC6A4) has been associated with a number of psychiatric disturbances, but conflicting replication followed.
|
11803453 |
2002 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
There is abundant evidence that the serotonin (5-HT) system is modulating mood and several behavioural traits and that disturbances in the regulation of this system can be associated with severe behavioural malfunctions, as aggressive implusive and suicidal behaviour.1 Recently a functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) was identified2 and the presence of one or two short alleles was associated with anxiety-related personality traits3 and several psychiatric disturbances, such as affective disorder4 or severe alcohol dependence.5 With respect to the importance of the 5-HT transporter in serotonergic transmission, we have genotyped the DNA of 58 Caucasian suicide victims (with unknown psychiatric diagnoses) and 110 healthy controls for the biallelic functional polymorphism in the 5-HTTLPR.
|
10822348 |
2000 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The S allele has been associated with a variety of psychiatric disorders and symptoms including alcohol dependence, but it is unknown whether 5-HTTLPR increases the risk for co-morbid sociopathy among those with alcohol dependence.
|
20192950 |
2011 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We investigated, in a large cohort of 5,608 controls and subjects suffering from various psychiatric disorders, the frequency of haplotypes and corresponding genotypes combining the 5-HTTLPR and the other serotonin transporter promoter functional variant (rs25531).
|
20862697 |
2010 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We have demonstrated in both the human serotonin transporter gene (5HTT) and the dopamine transporter gene (DAT1) that specific polymorphic variants termed Variable Number Tandem Repeats (VNTRs), which correlate with predisposition to a number of neurological and psychiatric disorders, act as transcriptional regulatory domains.
|
17960477 |
2008 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The genetic variations in norepinephrine transporter (NET) and serotonin transporter (SERT) genes have been associated with personality traits, several psychiatric disorders and the efficacy of antidepressant treatment.
|
25739526 |
2015 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Variation in the promoter region of the serotonin transporter gene (serotonin transporter-linked polymorphic region [5-HTTLPR]) is a particularly promising candidate in this context, which has been linked to psychiatric disorders as well as to limbic and prefrontal reactivity.
|
29760654 |
2018 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Serotonin transporter gene (SLC6A4) is one of the most promising candidate genes for psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BP).
|
16082508 |
2006 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results thus yield further insight into the role of the 5-HTTLPR in the background of neuroticism and neuroticism-related psychiatric disorders.
|
18806915 |
2009 |
|
Abnormal behavior
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In humans, the short (S) allele in the 5-HTT gene-linked polymorphic region, which decreases 5-HTT expression, has been shown to be associated with behavioral changes including an increased level of anxiety.
|
28465138 |
2017 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Alterations in 5-HT transmission have been linked to pathological symptoms in both intestinal and psychiatric disorders and selective 5-HT transporter (5-HTT) inhibitors, affecting the 5-HT system by blocking the 5-HT transporter (5-HTT) have been successfully used to treat CNS- and intestinal disorders.
|
28824378 |
2017 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The serotonin transporter (5-HTT) and tryptophan hydroxylase (TPH) gene are important candidate genes for the psychiatric disorders.
|
15722951 |
2005 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The serotonin transporter gene (SLC6A4), which plays a key role in the serotonergic pathway in the brain, is a candidate for mediating genetic susceptibility to various psychiatric disorders.
|
11324943 |
2000 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
A length polymorphism repeat in the 5-HTT promoter region, termed 5-HTTLPR, has been commonly investigated for an association with psychiatric disorders.
|
22921522 |
2013 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Both serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) genes have shown positive associations with obsessive-compulsive disorder (OCD) and some other psychiatric disorders, but these results have not been consistently replicated.
|
17375136 |
2007 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The newly derived 5-HTTLPR Phenotype Scale shows strong association with 5-HTTLPR genotype and phenotype, therefore this scale should be further investigated in relation to psychiatric disorders, as well as psychological traits and temperaments.
|
18455241 |
2009 |