SLC6A4, solute carrier family 6 member 4, 6532

N. diseases: 440; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease HPO
CUI: C0003467
Disease: Anxiety
Anxiety 		0.500 Biomarker disease HPO
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		0.300 Biomarker disease MGD
CUI: C0424290
Disease: Compulsive hoarding
Compulsive hoarding 		0.100 Biomarker disease HPO
CUI: C1696701
Disease: Skin-picking
Skin-picking 		0.100 Biomarker disease HPO
CUI: C4016373
Disease: OBSESSIVE-COMPULSIVE DISORDER, SUSCEPTIBILITY TO
OBSESSIVE-COMPULSIVE DISORDER, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.320 Biomarker phenotype CTD_human "Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine (""ecstasy"") users: relationship to cognitive performance." 18661256 2008
CUI: C0025261
Disease: Memory Disorders
Memory Disorders 		0.300 Biomarker disease CTD_human "Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine (""ecstasy"") users: relationship to cognitive performance." 18661256 2008
CUI: C0751292
Disease: Age-Related Memory Disorders
Age-Related Memory Disorders 		0.300 Biomarker group CTD_human "Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine (""ecstasy"") users: relationship to cognitive performance." 18661256 2008
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker phenotype CTD_human "Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine (""ecstasy"") users: relationship to cognitive performance." 18661256 2008
CUI: C0751294
Disease: Memory Disorder, Spatial
Memory Disorder, Spatial 		0.300 Biomarker phenotype CTD_human "Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine (""ecstasy"") users: relationship to cognitive performance." 18661256 2008
CUI: C0751295
Disease: Memory Loss
Memory Loss 		0.300 Biomarker phenotype CTD_human "Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine (""ecstasy"") users: relationship to cognitive performance." 18661256 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE "s" allele variant in the intron 2 of SERT gene could be associated with susceptibility to MDD. 16804504 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease BEFREE <b>Results:</b> 5-HTTLPR was associated with depression in PD patients and presence of the LL genotype was protective against the depression risk. 31024427 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease BEFREE <b>Results:</b> 5-HTTLPR was associated with depression in PD patients and presence of the LL genotype was protective against the depression risk. 31024427 2019
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 Biomarker phenotype BEFREE <b>Results:</b> 5-HTTLPR was associated with depression in PD patients and presence of the LL genotype was protective against the depression risk. 31024427 2019
CUI: C3160718
Disease: PARKINSON DISEASE, LATE-ONSET
PARKINSON DISEASE, LATE-ONSET 		0.030 Biomarker disease BEFREE <b>Results:</b> 5-HTTLPR was associated with depression in PD patients and presence of the LL genotype was protective against the depression risk. 31024427 2019
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		0.100 GeneticVariation phenotype BEFREE (1) The presence of the s/s genotype of the 5-HTTLPR polymorphism in the serotonin transporter promoter region and the 3/3 genotype of the 30-bp VNTR polymorphism in the monoamine oxidase A promoter region does not contribute to the development of depressive symptoms in late-reproductive-age women. 25826396 2015
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		0.100 GeneticVariation phenotype BEFREE (1) Treatment response of depressive symptoms (BDI, HAM-D, MADRS) to venlafaxine at week 4 was associated with the non-s/s (l/l and l/s) genotype of 5-HTTLPR; (2) in repeated measures ANOVA, the BDI, MADRS and HAM-A scores decreased more significantly in patients with the non-s/s genotype than in those with the s/s genotype, and (3) multiple regression analyses suggested that the 5-HTTLPR polymorphism is a predictive factor for short-term treatment response to venlafaxine. 20664233 2010
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.100 Biomarker disease BEFREE (1,2) Two recently published studies have implicated variation at a polymorphism in the promoter of the serotonin transporter (5HTT; hSERT) in influencing susceptibility to ADHD. 12232786 2002
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.600 Biomarker group BEFREE (1996) found that the frequency of the low-activity short variant (s) of the 5-HTT-linked polymorphic region (5-HTTLPR) was higher among patients with affective disorders than in normal controls. 9603609 1998
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 GeneticVariation disease BEFREE 1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G); 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G,)SL(A)) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution. 22520017 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 GeneticVariation disease BEFREE 1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G); 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G,)SL(A)) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution. 22520017 2012
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 GeneticVariation phenotype BEFREE 1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G); 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G,)SL(A)) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution. 22520017 2012
CUI: C0349217
Disease: Depressive episode, unspecified
Depressive episode, unspecified 		0.030 GeneticVariation disease BEFREE 112 inpatients (61 female) with a depressive episode (16 bipolar, 86 unipolar) at admission were genotyped for 5-HTTLPR variants. 23948632 2013