Sudden infant death syndrome
|
0.800 |
Biomarker
|
disease |
BEFREE |
Despite its functional role, results highlight the usefulness of 5HTT as a valuable tracer of SIDS risk in IALTE infants.
|
22711722 |
2012 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This article indicates that neither the VNTR in the promoter of the MAOA gene, nor rs25531 in the gene encoding 5-HTT, is involved in SIDS.
|
24286237 |
2014 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In our recent study allele variants in the promoter of serotonin transporter (5-HTT) gene have been shown as a novel risk factor for sudden infant death syndrome (SIDS).
|
12018976 |
2002 |
Sudden infant death syndrome
|
0.800 |
Biomarker
|
disease |
BEFREE |
Findings are discussed considering the metabolic association among DAT, 5-HTT and MAOA with special emphasis on the linked action of 5-HTT/MAOA in regulating serotonin metabolism of SIDS and SIUD infants.
|
18810510 |
2009 |
Sudden infant death syndrome
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Using qRT-PCR we studied the gene expression of 5-HTT in ten SIDS cases, previously analyzed at a molecular level and which showed the genetic S/S profile.
|
22771822 |
2013 |
Sudden infant death syndrome
|
0.800 |
Biomarker
|
disease |
BEFREE |
5-HT neuron count and density, 5-HT(1A) receptor binding density, and 5-HT transporter (5-HTT) binding density in the medullary 5-HT system; correlation between these markers and 6 recognized risk factors for SIDS.
|
17077377 |
2006 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the promoter of the 5-HTT gene may be of importance with regard to SIDS.
|
18477062 |
2008 |
Sudden infant death syndrome
|
0.800 |
Biomarker
|
disease |
BEFREE |
One of the candidate genes is the serotonin transporter (5-HTT) gene, based on decreased serotonergic receptor binding observed in the brain-stems of SIDS victims.
|
19261524 |
2009 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we aimed to identify the possibility that specific allele variants of the 5-HTT gene can be found as a genetic background for sudden infant death syndrome (SIDS).
|
11335745 |
2001 |
Sudden infant death syndrome
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
These data, if confirmed in larger studies, may begin to explain the differences in SIDS incidence by ethnicity, suggest a role for levels of 5-HTT expression in generation of SIDS susceptibility, and provide an important tool for identifying at-risk individuals and estimating the risk of recurrence.
|
12966525 |
2003 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
These results indicate a relationship between SIDS and the L allele of the 5-HTT gene in African Americans and Caucasians, and if confirmed, will provide an important tool for identifying at-risk individuals and estimating the risk of recurrence.
|
12599191 |
2003 |
Sudden infant death syndrome
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
These observations do not support previous findings that the L allele and/or LL genotype of the 5-HTTLPR are associated with SIDS.
|
20661167 |
2010 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Additionally, to elucidate pathophysiological mechanisms that could explain the relations between MUPS and depression, we investigate the association between a sustained high level of MUPS, and (I) omega (ω)-3 and -6 fatty acid (FA)-status and (II) functional polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR).
|
22100130 |
2012 |
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Antidepressants that block the serotonin transporter, (Slc6a4/SERT), selective serotonin reuptake inhibitors (SSRIs) improve mood in adults but have paradoxical long-term effects when administered during perinatal periods, increasing the risk to develop anxiety and depression.
|
30279456 |
2019 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A deletion/insertion polymorphism within the 5-HT transporter promoter gene (5-HTTLPR) is thought to be associated with disturbed impulse control, anxiety, and depression.
|
20010449 |
2010 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A common regulatory variant (5-HTTLPR) in the human serotonin transporter gene (SLC6A4), resulting in altered transcription and transporter availability, has been associated with vulnerability for affective disorders, including anxiety and depression.
|
15699291 |
2005 |
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
We test associations between 5-HTTLPR and (1) behavioral traits and (2) clinical diagnoses of anxiety and depression.
|
28391138 |
2017 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Seasonal variations in mood and behavior (seasonality) and seasonal affective disorder (SAD) have been attributed to seasonal fluctuations in brain serotonin (5-HT). the short (s), as opposed to the long (l), allele of the 5-HT transporter linked polymorphism (5-HTTLPR) has been associated with neuroticism and depression.
|
9577843 |
1998 |
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Previous studies have identified SLC6A4 and HTR2A associations with SSRI response in patients with depression and 5-HTTLPR (SLC6A4) associations with escitalopram response in ASD.
|
26262902 |
2015 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In those with depression, the short allele of 5-HTT was associated with smaller caudate nucleus volumes.
|
16930719 |
2007 |
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
The present study was conducted to explore whether the polymorphism and methylation status of the serotonin transporter gene (5HTT) promoter region (PR-5HTT) contribute to depression in SLE patients from both genetic and epigenetic perspectives.
|
23893825 |
2013 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Since both posttraumatic stress disorder (PTSD) and depression are associated with disturbances in the serotoninergic system, the aim of the study was to determine the association between severity of PTSD symptoms, serotonin transporter polymorphism (5-HTTLPR) and platelet serotonin (5-HT) concentration, in male combat veterans with PTSD (n = 325), who were subdivided according to presence of comorbid depression.
|
27525827 |
2016 |
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our results show that 5-HTTLPR is related to cognitive vulnerability to depression.
|
20455953 |
2010 |
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Many studies have focused on the relationship between the 5-HTT-linked polymorphic region (5-HTTLPR) and depression.
|
19429111 |
2009 |
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A number of studies have shown that the presence of short (S) allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) is associated with a higher risk for depression following exposure to stressful life events.
|
29129791 |
2018 |