|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotyping was performed for AMD risk polymorphisms associated with age-related maculopathy susceptibility 2 (ARMS2), high-temperature requirement factor A1 (HTRA1), complement factor H (CFH), and complement C3.
|
20238042 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.
|
20861866 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.
|
20861866 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort.
|
20157618 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic loci (complement factor H [CFH], complement factor B [CFB], the age-related maculopathy susceptibility 2 locus containing the hypothetical gene [LOC387715]/the high-temperature requirement A-1 [HTRA1], and complement component 3 [C3]) that were already known to be associated with AMD were identified.
|
21197116 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether the previously reported noncoding variant of the complement factor H (CFH) gene and two coding variants of the complement component 3 (C3) gene are associated with exudative age-related macular degeneration (AMD) in Chinese patients.
|
19850835 |
2010 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotyping was performed for AMD risk polymorphisms associated with age-related maculopathy susceptibility 2 (ARMS2), high temperature requirement factor A1 (HTRA1), complement factor H, and complement C3, and the risk of AMD was predicted based on genotype alone or in combination with the CEP markers.
|
19202148 |
2009 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our study showed a significant association between variants in the C3 gene and AMD and further highlights the crucial role of the complement pathway in the etiology of AMD.
|
19168221 |
2009 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Our study showed a significant association between variants in the C3 gene and AMD and further highlights the crucial role of the complement pathway in the etiology of AMD.
|
19168221 |
2009 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
C3 R102G polymorphism increases risk of age-related macular degeneration.
|
18325906 |
2008 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Subjects were analyzed for single nucleotide polymorphisms in factor H (CFH), factor B-C2 (BF-C2) and complement C3 (C3) genes which were previously found to be associated with AMD.
|
18596911 |
2008 |
|
COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome.
|
18796626 |
2008 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
CTD_human |
Variation in complement factor 3 is associated with risk of age-related macular degeneration.
|
17767156 |
2007 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Complement C3 variant and the risk of age-related macular degeneration.
|
17634448 |
2007 |
|
Age related macular degeneration
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Estimation of systemic complement C3 activity in age-related macular degeneration.
|
17420372 |
2007 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
LHGDN |
Variation in complement factor 3 is associated with risk of age-related macular degeneration.
|
17767156 |
2007 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Complement C3 variant and the risk of age-related macular degeneration.
|
17634448 |
2007 |
|
COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Molecular analysis of a novel hereditary C3 deficiency with systemic lupus erythematosus.
|
15781264 |
2005 |
|
COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Molecular analysis of a novel hereditary C3 deficiency with systemic lupus erythematosus.
|
15781264 |
2005 |
|
COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (ASP549 to ASN) impairs C3 secretion.
|
7961791 |
1994 |
|
COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Homozygous deficiency of C3 in a patient with repeated infections.
|
4117597 |
1972 |