|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Fluvoxamine efficacy in delusional depression seems to be related to allelic variation within the promoter of the 5-HTT gene.
|
9857976 |
1998 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism in the promoter region of the gene (SLC6A4) encoding this protein, was recently reported to affect protein expression and to be associated with measures of anxiety and depression and with autism (using a family-controlled transmission disequilibrium test (TDT) design).
|
9672904 |
1998 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our tentative association findings in dissocial alcoholics suggest that the S allele of the 5' regulatory SLC6A4 polymorphism confers susceptibility to a temperamental profile of high novelty seeking and low harm avoidance that has been postulated to underlie dissocial (type-2) alcoholism according to Cloninger's neurogenetic theory of personality.
|
9627746 |
1998 |
|
Anxiety Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
In the present study we replicated the relationship of SLC6A4*C to anxiety by sibpair linkage analysis but found no evidence of association, raising the question of whether SLC6A4*C locus is itself affecting anxiety or is linked to another still unknown functional variant.
|
9783565 |
1998 |
|
Anxiety Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
A polymorphism in the promoter region of the gene (SLC6A4) encoding this protein, was recently reported to affect protein expression and to be associated with measures of anxiety and depression and with autism (using a family-controlled transmission disequilibrium test (TDT) design).
|
9672904 |
1998 |
|
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
By affected-sib-pair analysis and the transmission/disequilibrium test, we found no significant linkage or association of 5-HTT to bipolar disorder.
|
9514585 |
1998 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have analyzed 86 unrelated patients (47 with bipolar disorder and 39 with schizophrenia) and 98 normal controls from the Brazilian population for the 5-HTTLPR.
|
9603609 |
1998 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the genetic variability of the 5-HTT gene is not a major risk factor for manic depression.
|
9611675 |
1998 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present study analysed this variation and another variation in the SERT gene and nearby DNA markers in order to test for linkage between SERT and bipolar affective disorder in two Danish families.
|
9543202 |
1998 |
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Allelic association case-control analysis of a deletion/insertion polymorphism in the serotonin transporter-linked polymorphic region (5-HTTLPR) has suggested associations with unipolar disorder, bipolar disorder, depression, and Alzheimer's disease.
|
9848084 |
1998 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Fluvoxamine efficacy in delusional depression seems to be related to allelic variation within the promoter of the 5-HTT gene.
|
9857976 |
1998 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Seasonal variations in mood and behavior (seasonality) and seasonal affective disorder (SAD) have been attributed to seasonal fluctuations in brain serotonin (5-HT). the short (s), as opposed to the long (l), allele of the 5-HT transporter linked polymorphism (5-HTTLPR) has been associated with neuroticism and depression.
|
9577843 |
1998 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism in the promoter region of the gene (SLC6A4) encoding this protein, was recently reported to affect protein expression and to be associated with measures of anxiety and depression and with autism (using a family-controlled transmission disequilibrium test (TDT) design).
|
9672904 |
1998 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data provide preliminary support for association and linkage disequilibrium between the SLC6A4 'l' allele and OCD.
|
9672904 |
1998 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, variability in the SERT gene was analyzed for the first time in a sample of patients with major depression with melancholia (MDDM) in the context of a genetic association study.
|
9799087 |
1998 |
|
Mood Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
A polymorphism in the 5'-flanking regulatory region of the 5-HTT gene that results in allelic variation of 5-HTT expression is associated with anxiety-related personality traits and may influence the risk of developing affective disorders.
|
9693390 |
1998 |
|
Mood Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
Taken together, our data suggest that the 5-HTT gene is not commonly involved in the susceptibility to mood disorders.
|
9514579 |
1998 |
|
Mood Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
To explore the involvement of serotonin transporter (5HTT) in mood disorder, we studied two polymorphisms of the 5HTT gene (a variable number of tandem repeats in the second intron (VNTR) and a 44 bp insertion/deletion in the 5HTT linked polymorphic region (5-HTTLPR)) in a sample of unipolar and bipolar patients and controls.
|
9832193 |
1998 |
|
Mood Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
There is some evidence suggesting that a polymorphism of variable number of tandem repeats (VNTR) in the second intron of the serotonin transporter (5-HTT) gene and another variation which lies 1.2 kb upstream of the promoter of the gene (5-HTTLPR) are associated with affective disorders.
|
9399688 |
1998 |
|
Mood Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
There was no evidence that variants in the SERT gene were a stronger dominant disease gene for the development of affective disorder in the families.
|
9543202 |
1998 |
|
Mood Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders.
|
9787878 |
1998 |
|
Mood Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The serotonin transporter (SERT) gene is a particularly interesting candidate for genetic involvement in affective disorders owing to its role in both the regulation of serotonergic neurotransmission and the mechanism of action of many antidepressant drugs.
|
9799087 |
1998 |
|
Mood Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
(1996) found that the frequency of the low-activity short variant (s) of the 5-HTT-linked polymorphic region (5-HTTLPR) was higher among patients with affective disorders than in normal controls.
|
9603609 |
1998 |
|
Mood Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
Interactions with antidepressants, as well as other biochemical evidence, implicate the serotonin transporter 5-HTT in the etiology of affective disorders.
|
9514585 |
1998 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, variability in the SERT gene was analyzed for the first time in a sample of patients with major depression with melancholia (MDDM) in the context of a genetic association study.
|
9799087 |
1998 |