SLC6A4, solute carrier family 6 member 4, 6532

N. diseases: 440; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.600 GeneticVariation disease BEFREE 252 unrelated Caucasian patients (f = 142; m = 110) with major depression were genotyped for NET and 5-HTT polymorphisms. 20588071 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE 252 unrelated Caucasian patients (f = 142; m = 110) with major depression were genotyped for NET and 5-HTT polymorphisms. 20588071 2010
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 GeneticVariation disease LHGDN 3' UTR polymorphism of the serotonin transporter gene and sudden infant death syndrome: haplotype analysis. 16691588 2006
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.600 GeneticVariation disease BEFREE 49 patients with major depression and SSRI treatment were genotyped for the 5-HTTLPR locus including the rs25531. 22086748 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE 49 patients with major depression and SSRI treatment were genotyped for the 5-HTTLPR locus including the rs25531. 22086748 2012
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.800 Biomarker disease BEFREE 5-HT neuron count and density, 5-HT(1A) receptor binding density, and 5-HT transporter (5-HTT) binding density in the medullary 5-HT system; correlation between these markers and 6 recognized risk factors for SIDS. 17077377 2006
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders 		0.300 Biomarker group CTD_human 5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence. 23209555 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease BEFREE Depression status and gender were examined as potential modifiers of the association between 5-HTTLPR and personality. 12605095 2003
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease BEFREE Depression status and gender were examined as potential modifiers of the association between 5-HTTLPR and personality. 12605095 2003
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 Biomarker phenotype BEFREE Depression status and gender were examined as potential modifiers of the association between 5-HTTLPR and personality. 12605095 2003
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 Biomarker disease BEFREE Depression has been associated with a decrease in intracellular serotonin (5-HT) reuptake through its transporter, SERT. 12759553 2003
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease BEFREE Depression has been associated with a decrease in intracellular serotonin (5-HT) reuptake through its transporter, SERT. 12759553 2003
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 Biomarker phenotype BEFREE Depression has been associated with a decrease in intracellular serotonin (5-HT) reuptake through its transporter, SERT. 12759553 2003
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker disease PSYGENET Melancholic depression was associated with the 5-HTTLPR long (l) allele and atypical depression with the 5-HTTLPR s-allele (two-sided Fisher's exact test: genotype distribution: P=0.0038; allele frequencies: P=0.007). 14593433 2003
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 GeneticVariation disease BEFREE Melancholic depression was associated with the 5-HTTLPR long (l) allele and atypical depression with the 5-HTTLPR s-allele (two-sided Fisher's exact test: genotype distribution: P=0.0038; allele frequencies: P=0.007). 14593433 2003
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		0.100 GeneticVariation phenotype BEFREE Depressive symptoms and major depressive disorder in elderly persons after a stressful medical event may be associated with 5-HTTLPR genotype. 15879594 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.600 GeneticVariation group BEFREE Mood disorder subjects (N=191) and healthy volunteers (N=125), all Caucasian subjects of European origin, were genotyped for the triallelic 5-HTTLPR polymorphism (higher expressing allele: L(A); lower expressing alleles: L(G), S). 16946185 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 GeneticVariation disease BEFREE Depression and psychotic symptoms that occur in a large proportion of AD patients have been associated with monoamine genes coding for metabolic enzymes (COMT), transporters (5-HTTLPR) and receptors (DRD1; DRD3). 17851196 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 GeneticVariation disease BEFREE Depression and psychotic symptoms that occur in a large proportion of AD patients have been associated with monoamine genes coding for metabolic enzymes (COMT), transporters (5-HTTLPR) and receptors (DRD1; DRD3). 17851196 2007
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 GeneticVariation phenotype BEFREE Depression and psychotic symptoms that occur in a large proportion of AD patients have been associated with monoamine genes coding for metabolic enzymes (COMT), transporters (5-HTTLPR) and receptors (DRD1; DRD3). 17851196 2007
CUI: C0008060
Disease: child abuse behavior
child abuse behavior 		0.090 GeneticVariation phenotype BEFREE Child maltreatment and polymorphisms of the serotonin transporter (5-HTT) and monoamine oxidase A (MAOA) genes were examined in relation to depressive symptomatology. 17931441 2007
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.100 GeneticVariation disease BEFREE ADHD and Disruptive Behavior scores - associations with MAO-A and 5-HTT genes and with platelet MAO-B activity in adolescents. 18430257 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.700 GeneticVariation disease BEFREE Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene-environment interaction. 18534686 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 GeneticVariation disease BEFREE Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene-environment interaction. 18534686 2008
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 GeneticVariation phenotype BEFREE Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene-environment interaction. 18534686 2008