SLC6A4, solute carrier family 6 member 4, 6532

N. diseases: 440; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 AlteredExpression disease BEFREE More importantly, no association between alleles conveying functional differences in 5-HTT gene expression and MDD or BD could be found. 9514579 1998
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 GeneticVariation disease BEFREE According to these results, variability in the SERT gene has a small effect on liability to MDDM. 9799087 1998
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker disease PSYGENET According to these results, variability in the SERT gene has a small effect on liability to MDDM. 9799087 1998
CUI: C0003467
Disease: Anxiety
Anxiety 		0.500 GeneticVariation disease BEFREE A polymorphism in the promoter region of the gene (SLC6A4) encoding this protein, was recently reported to affect protein expression and to be associated with measures of anxiety and depression and with autism (using a family-controlled transmission disequilibrium test (TDT) design). 9672904 1998
CUI: C0003467
Disease: Anxiety
Anxiety 		0.500 Biomarker disease BEFREE In the present study we replicated the relationship of SLC6A4*C to anxiety by sibpair linkage analysis but found no evidence of association, raising the question of whether SLC6A4*C locus is itself affecting anxiety or is linked to another still unknown functional variant. 9783565 1998
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.400 GeneticVariation disease BEFREE A polymorphism in the promoter region of the gene (SLC6A4) encoding this protein, was recently reported to affect protein expression and to be associated with measures of anxiety and depression and with autism (using a family-controlled transmission disequilibrium test (TDT) design). 9672904 1998
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease BEFREE Although it will be important to extend the present analysis in a larger sample, our preliminary results suggest that the 5-HTTLPR does not seem to play a major role in the genetics of bipolar and schizophrenic disorders at least in this group of Brazilian psychiatric patients. 9603609 1998
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 AlteredExpression disease BEFREE Our data suggest that 5-HTTLPR genotype neither confers an increased susceptibility for schizophrenia nor dictates the expression of the 5-HTT in the human hippocampus. 9848084 1998
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.400 GeneticVariation disease BEFREE The 5-HTTLPR short allele contributes to the trait of seasonality and is a risk factor for SAD, providing further evidence for a relationship between genetic variation in the 5-HT transporter (5-HTT) and behavior. 9577843 1998
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 GeneticVariation phenotype BEFREE Seasonal variations in mood and behavior (seasonality) and seasonal affective disorder (SAD) have been attributed to seasonal fluctuations in brain serotonin (5-HT). the short (s), as opposed to the long (l), allele of the 5-HT transporter linked polymorphism (5-HTTLPR) has been associated with neuroticism and depression. 9577843 1998
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 GeneticVariation phenotype BEFREE Fluvoxamine efficacy in delusional depression seems to be related to allelic variation within the promoter of the 5-HTT gene. 9857976 1998
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 GeneticVariation phenotype BEFREE A polymorphism in the promoter region of the gene (SLC6A4) encoding this protein, was recently reported to affect protein expression and to be associated with measures of anxiety and depression and with autism (using a family-controlled transmission disequilibrium test (TDT) design). 9672904 1998
CUI: C1510472
Disease: Drug Dependence
Drug Dependence 		0.330 GeneticVariation group BEFREE Progress in 5-HTT gene inactivation studies are also changing views of the relevance of adaptive 5-HT uptake function in brain development and plasticity as well as processes underlying drug dependence and neurodegeneration. 9693390 1998
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.100 GeneticVariation disease BEFREE Allelic association case-control analysis of a deletion/insertion polymorphism in the serotonin transporter-linked polymorphic region (5-HTTLPR) has suggested associations with unipolar disorder, bipolar disorder, depression, and Alzheimer's disease. 9848084 1998
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders 		0.100 GeneticVariation group BEFREE Patients with the 5-HTTLPR II genotype (n = 19) had significantly higher BPRS ratings for psychosis than patients with the Is (n = 25) or ss (n = 6) genotypes. 9702741 1998
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis 		0.100 GeneticVariation disease BEFREE Patients with the 5-HTTLPR II genotype (n = 19) had significantly higher BPRS ratings for psychosis than patients with the Is (n = 25) or ss (n = 6) genotypes. 9702741 1998
CUI: C1842981
Disease: NEUROTICISM
NEUROTICISM 		0.100 GeneticVariation disease BEFREE A polymorphism located in the 5' promoter region of the gene is associated with altered transcriptional activity of SLC6A4; an earlier study reported an association of the polymorphism with anxiety- and depression-related traits, including harm avoidance and neuroticism. 9766763 1998
CUI: C1842981
Disease: NEUROTICISM
NEUROTICISM 		0.100 Biomarker disease BEFREE A functional polymorphism in the promoter of the human serotonin transporter gene (SLC6A4*C) was identified and found to be linked to an anxiety-related personality trait, Neuroticism. 9783565 1998
CUI: C1842981
Disease: NEUROTICISM
NEUROTICISM 		0.100 GeneticVariation disease BEFREE Seasonal variations in mood and behavior (seasonality) and seasonal affective disorder (SAD) have been attributed to seasonal fluctuations in brain serotonin (5-HT). the short (s), as opposed to the long (l), allele of the 5-HT transporter linked polymorphism (5-HTTLPR) has been associated with neuroticism and depression. 9577843 1998
CUI: C1839839
Disease: MAJOR AFFECTIVE DISORDER 2
MAJOR AFFECTIVE DISORDER 2 		0.080 GeneticVariation disease BEFREE Serotonin transporter (5-HTT) gene and bipolar affective disorder. 9514585 1998
CUI: C1839839
Disease: MAJOR AFFECTIVE DISORDER 2
MAJOR AFFECTIVE DISORDER 2 		0.080 GeneticVariation disease BEFREE The present study analysed this variation and another variation in the SERT gene and nearby DNA markers in order to test for linkage between SERT and bipolar affective disorder in two Danish families. 9543202 1998
CUI: C1839839
Disease: MAJOR AFFECTIVE DISORDER 2
MAJOR AFFECTIVE DISORDER 2 		0.080 GeneticVariation disease BEFREE To test this hypothesis, we analyzed allele, genotype, and haplotype frequencies of two polymorphisms recently described in the 5-HTT gene (a variable number of tandem repeats in intron 2 and a deletion/insertion polymorphism in the transcriptional control region) in a sample of 88 patients with manic-depressive illness and 113 controls. 9611675 1998
CUI: C0497327
Disease: Dementia
Dementia 		0.050 Biomarker disease BEFREE Integration of various strategies, including molecular genetic, transgenic, and gene transfer techniques, will allow elucidation of the 5-HTT's role in brain development, plasticity, and degeneration as well as in affective illness, drug abuse, and dementia. 9693390 1998
CUI: C1852197
Disease: MAJOR AFFECTIVE DISORDER 1
MAJOR AFFECTIVE DISORDER 1 		0.050 GeneticVariation disease BEFREE The present study analysed this variation and another variation in the SERT gene and nearby DNA markers in order to test for linkage between SERT and bipolar affective disorder in two Danish families. 9543202 1998
CUI: C1852197
Disease: MAJOR AFFECTIVE DISORDER 1
MAJOR AFFECTIVE DISORDER 1 		0.050 GeneticVariation disease BEFREE Serotonin transporter (5-HTT) gene and bipolar affective disorder. 9514585 1998