|
Depressive disorder
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
The present study investigated the association of 5-HTTLPR polymorphism and CpG DNA methylation (5mC) levels of an AluJb repeat element at the SLC6A4 promoter region in mother-child pairs exposed to maternal depression.
|
30447571 |
2019 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Many research studies have demonstrated conflicting results, and the contribution of 5-HTTLPR to depression is unclear.
|
29982901 |
2019 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
5-HTT binding potential mediated the relationship between AA and depression severity.
|
31319341 |
2019 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The serotonin transporter (SERT) gene has been linked to depression, especially the short allele of the serotonin transporter linked polymorphic region (5-HTTLPR).
|
30176268 |
2019 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The S allele of 5-HTTLPR combined with exposure to childhood adversity or a poorer parenting environment was associated with a smaller hippocampal volume and subsequent onset of depression.
|
29535036 |
2019 |
|
Depressive disorder
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1.
|
30529315 |
2019 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Increasing evidence have indicated the strong association of stress, especially the chronic stress and early life stress, with depressive disorders development, while the association of stress with depression is moderated by genetic risk factors, including polymorphism of SERT, BDNF, GR, FKBP5, MR, and CRHR1.
|
31784962 |
2019 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Over-representation of the LL genotype of the 5-HTTLPR and higher platelet 5-HT concentrations were detected in veterans with PTSD who did not develop comorbid depression but had severe early insomnia.
|
30948693 |
2019 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In humans, the short allele of a common polymorphism in the serotonin transporter (5-HTT) gene is associated with a higher risk to develop depression and anxiety disorders.
|
31849623 |
2019 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We found that the association between SLE load and MS depression severity was stronger among those with one or two copies of the short allele of the 5-HTTLPR.
|
29683385 |
2019 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A number of studies have shown that the presence of short (S) allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) is associated with a higher risk for depression following exposure to stressful life events.
|
29129791 |
2018 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Individualization of therapy for depression may be achieved through consideration of the specific associations that patients exhibit between life stress, 5-HTTLPR polymorphism, and depression symptomatology.
|
30127611 |
2018 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Results showed a small but significant effect of 5-HTTLPR in interaction with stress in the prediction of depression (OR[95%CI] = 1.18[1.09; 1.28], n = 48 effect sizes from 51 studies, totaling 51,449 participants).
|
29031184 |
2018 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
To determine the magnitude of the interaction and the conditions under which it might be observed, we performed new analyses on 31 data sets containing 38 802 European ancestry subjects genotyped for 5-HTTLPR and assessed for depression and childhood maltreatment or other stressful life events, and meta-analysed the results.
|
28373689 |
2018 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In addition, we found two genes, SLC6A4 and SLC6A2, to be the main therapeutic targets, and Serotonin-Norepinephrine Reuptake Inhibitors (SNRI) and Tricyclic Antidepressants (TCA) to be the most effective drugs for individuals with depression at risk for suicide.
|
29331709 |
2018 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present conceptual replication study was to investigate the role of biased automatic approach-avoidance tendencies as a candidate intermediate phenotype for depression, in the context of genes (5-HTTLPR polymorphism) and childhood trauma.
|
29547643 |
2018 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
The human monoamine transporters (hMATs) primary including hSERT, hNET and hDAT are important targets for the treatment of depression and other behavioral disorders with more than availability of 30 approved drugs.
|
30306851 |
2018 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Additionally, we found no relationship between pretreatment amygdala binding and posttreatment depression score, and were unable to predict posttreatment depression severity using both pretreatment 5-HTT (in the amygdala) and 5-HT<sub>1A</sub> binding (in the raphe).
|
28935838 |
2018 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here we examined whether emotional inertia, the tendency for a person's emotions to carry over from 1 moment to the next and a prospective predictor of the development of depression, is associated with a known genetic risk factor for emotional dysregulation, a polymorphism in the serotonin transporter gene (5-HTTLPR).
|
28569537 |
2018 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Participants (N = 92) were from a family cohort study of depression in which we have previously shown a broad distribution of 5-HTT variants.
|
28444137 |
2018 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The S allele of serotonin transporter gene (5-HTTLPR) has been found to increase the risk of depression and other mental health problems, but some evidence suggests that S-allele carriers outperform subjects carrying the long allele in an array of cognitive tasks.
|
29913130 |
2018 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine whether genetic variation in the SLC6A4 gene influences promoter DNA methylation, and whether these are associated with depression status.
|
30180828 |
2018 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
There are changes in gut microbiota composition and gut microbial profile (butyrate, GABA, β-hydroxybutyrate) effecting epigenetic regulation (histone acetylation, DNA methylation) and gene expression of receptors and mediators (SLC6A4, BDNF, GABA, GPRs) involved in depressive disorders.
|
29930222 |
2018 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Amitifadine, the only drug ever clinically tested in Phase 3 for treating depression, is a triple reuptake inhibitor (TRI) that simultaneously interacts with human monoamine transporters (MATs) including hSERT, hNET and hDAT.
|
29451287 |
2018 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
The serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) is thought to alter 5-HT signaling and contribute to behavioral and cognitive phenotypes in depression as well as Alzheimer disease (AD).
|
30147642 |
2018 |