|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
We test associations between 5-HTTLPR and (1) behavioral traits and (2) clinical diagnoses of anxiety and depression.
|
28391138 |
2017 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The findings indicate that ELBW/SGAs carrying the 5-HTTLPR short allele reported increased internalizing problems, particularly depression, during the third and fourth decades of life.
|
27416920 |
2017 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
As impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (SERT 5-HTTLPR, MAO-A VNTR, COMT Val158Met and DAT VNTR) and schizophrenia.
|
28416295 |
2017 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the present study, the number of 5-HT- and TPH-positive cells, and expression of 5-HT<sub>1A</sub> and 5-HTT protein decreased in dorsal raphe, and depression and anxiety like behavior increased in HFD group compared with the CON group.
|
28142069 |
2017 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings indicate that 5-HTTLPR genetic variability appears to influence the association between stress-related factors and late-life depression, although the gene-environment interactions failed to reach statistical significance levels.
|
28024274 |
2017 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
The serotonin transporter (5-HTT) is a key feature of the serotonin system, which is involved in behavior, cognition and personality and implicated in neuropsychiatric illnesses including depression.
|
28195567 |
2017 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings may explain some of the 'null' findings regarding the link between the 5-HTTLPR and depression in the wider literature by arguing for an interaction between these two factors in the association between major stress and depression.
|
28774788 |
2017 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
One reason for this inconsistency might be the fact that the interaction of the 5-HTTLPR polymorphism with stress may relate not to depression per se, but rather to adaptive or maladaptive emotion regulation strategies.
|
28901577 |
2017 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Seven studies were identified by the systematic review, with complete data sets of five community (n = 1750, 64.5% female) and two clinical (n = 426, 100% female) samples combined to perform four secondary-data analyses: 5-HTTLPR x Traumatic Life Events to predict ED status (n = 909), 5-HTTLPR x Sexual and Physical Abuse to predict bulimic symptoms (n = 1097), 5-HTTLPR x Depression to predict bulimic symptoms (n = 1256), and 5-HTTLPR x Impulsiveness to predict disordered eating (n = 1149).
|
27701012 |
2017 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association between serotonin transporter polymorphisms (5-HTTLPR) and the MADRS Dysphoria, Retardation, and Vegetative Subscale scores in the treatment of depression.
|
28652746 |
2017 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
An interaction between FA in the right uncinate fasciculus and 5-HTTLPR also predicted percent change in depression severity [F(5, 25) = 5.315, p = 0.002].
|
27277475 |
2017 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Individuals with s/s genotype of serotonin transporter gene-linked promotor region (5-HTTLPR), which appear with a high frequency in Japanese, exhibit more diagnosable depression in relation to stressful life events than those with the s/l or l/l genotype.
|
28638109 |
2017 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months.
|
27427178 |
2017 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Most studies showed BDNF and NR3C1 gene methylation levels were correlated with depression while the connection of SLC6A4 and depression was conflicting.
|
28645747 |
2017 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In line with this, mice with varying 5-HTT genotypes are invaluable tools to study depression- and anxiety-like behaviours as well as the mechanisms mediating potential therapeutics.
|
28629963 |
2017 |
|
Depressive disorder
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
The serotonin transporter gene (SLC6A4) methylation was similarly affected in stress, depression and burnout.
|
27998510 |
2017 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Gender-specific association between serotonin transporter polymorphisms (5-HTTLPR and rs25531) and neuroticism, anxiety and depression in well-defined healthy Han Chinese.
|
27788383 |
2017 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The serotonin transporter-linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) S allele is linked to pathogenesis of depression and slower response to selective serotonin reuptake inhibitors (SSRIs); depression and SSRIs are independently associated with bone loss.
|
28892067 |
2017 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Using functional MRI, we investigated whether and how the serotonin transporter promoter polymorphism (5-HTTLPR), which has been associated with mental disorders such as anxiety and depression, moderates the associations between a cultural trait (i.e., interdependence) and self-report of death anxiety/depression and between interdependence and brain responses to mortality threats.
|
28921740 |
2017 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Specifically, adult restoration of serotonin 4 receptor (5-HT<sub>4</sub>R) expression in the mPFC rescues hypophagia and specific molecular changes related to depression resistance in the DR (5-HT release elevation, 5-HT<sub>1A</sub> receptor, and 5-HT transporter reductions) of stressed 5-HT<sub>4</sub>R knockout mice.
|
29069597 |
2017 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Therefore, inhibition of SERT is a potent strategy for the treatment of related diseases such as depression.
|
28499269 |
2017 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
5-HTTLPR moderates the association between attention away from angry faces and prospective depression among youth.
|
28325682 |
2017 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
The serotonin transporter (5-HTT) regulates serotonin homeostasis and has been used as a target for different drugs in depression treatment.
|
28756191 |
2017 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Given the high prevalence of depression in chronic pain, the primary aim of this preliminary study was to investigate the associations between the 5-HTTLPR and the severity of depressive symptoms in a cohort of adults with chronic pain.
|
28533695 |
2017 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
While SLC6A4 hypermethylation has typically been described to be independently associated with both early life stress and depressive disorders, only a few papers address whether methylation could mediate the interaction between stress and 5-HTTLPR in predicting psychopathological risk.
|
27880876 |
2017 |