|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The interaction of early life stress (ELS) and the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) has been associated with increased risk to develop depression in later life.
|
27826101 |
2017 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that the antidepressant actions of vortioxetine may be SERT-independent, and encourage consideration of agents that mimic one or more actions of the drug in the development of improved depression treatments.
|
28272863 |
2017 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Since both posttraumatic stress disorder (PTSD) and depression are associated with disturbances in the serotoninergic system, the aim of the study was to determine the association between severity of PTSD symptoms, serotonin transporter polymorphism (5-HTTLPR) and platelet serotonin (5-HT) concentration, in male combat veterans with PTSD (n = 325), who were subdivided according to presence of comorbid depression.
|
27525827 |
2016 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The serotonin transporter-linked polymorphic region (5-HTTLPR) has been examined as a factor associated with depression and other mental disorders.
|
26909988 |
2016 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Serotonin transporter linked polymorphic region (5-HTTLPR) was reported to associate with depression in systemic lupus erythematosus (SLE) patients by our team.
|
27819008 |
2016 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
The association of single nucleotide polymorphisms of BDNF, NPSR1 and 5-HTT with anxiety and depression in asthamtic patients was evaluated.
|
27176146 |
2016 |
|
Depressive disorder
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Findings revealed that SLC6A4 methylation has been investigated in humans in association with a number of prenatal and postnatal adverse exposures, encompassing maternal depression during pregnancy, perinatal stress exposure, childhood trauma and abuse, and environmental stress.
|
27565518 |
2016 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Further, we employ a design that addresses specific limitations of many prior studies that have examined the 5-HTTLPR × SLE relation, by: (a) using a within-person repeated-measures design to address fluctuations that occur within individuals over time, increase power for detecting G × E, and address GE correlation; (b) studying reports of exogenous stressful events (those unlikely to be caused by depression) to help rule out reverse causation and negativity bias, and in order to assess stressors that are more etiologically relevant to depressive symptomatology in older adults.
|
26330209 |
2016 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Citation bias and selective focus on positive findings in the literature on the serotonin transporter gene (5-HTTLPR), life stress and depression.
|
27515846 |
2016 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results provide partial support for the original hypothesis that 5-HTTLPR genotype interacts with the experience of stressful life events in the etiology of depression during young adulthood.
|
26938215 |
2016 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism of rs3813034 in Serotonin Transporter Gene SLC6A4 Is Associated With the Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Response in Depressive Disorder: Sequencing Analysis of SLC6A4.
|
26674707 |
2016 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Only a nominal interaction was found between life events overall and 5-HTTLPR on depression, which failed to survive correction for multiple testing.
|
27138797 |
2016 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our preliminary results suggest that the 5-HTTLPR polymorphism is associated with morphometric changes in regions known to play an important role in emotional and reward processing in depression.
|
26976307 |
2016 |
|
Depressive disorder
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The aims of this study were (1) to investigate the association between 5HTT methylation or expression in leukocytes and depression and (2) to investigate a possible effect of 5HTT methylation, expression, and genotype on clinical symptoms in MDD.
|
27005686 |
2016 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Previous studies have identified SLC6A4 and HTR2A associations with SSRI response in patients with depression and 5-HTTLPR (SLC6A4) associations with escitalopram response in ASD.
|
26262902 |
2015 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The NET and 5-HT1A polymorphisms appear to have similar effects on hippocampal volume in patients and controls while the 5-HTTLPR polymorphism differentially affects hippocampal volume in the presence of depression.
|
25990886 |
2015 |
|
Depressive disorder
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Selective serotonin reuptake inhibitors (SSRIs), such as citalopram, which selectively block serotonin transporter (5-HTT) activity, are widely used in the treatment of depression and anxiety disorders.
|
25745133 |
2015 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Since the 5-HT network is involved in interferon (IFN)-induced depression, this paper aimed to investigate the role of alexithymia and the functional gene variants of the 5-HT1A receptor (HTR1A) and the 5-HT transporter (5-HTTLPR) in induction of depression during antiviral treatment.
|
26609890 |
2015 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These findings provide further evidence that a genetic variant in the 5-HTTLPR moderates the link between childhood maltreatment and youth depression.
|
26315979 |
2015 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
The 5-HTTLPR and its interaction with adverse life events has been studied widely; especially with regard to depression.
|
24374553 |
2015 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
More specifically, the short (S) allele of 5-HTTLPR has been linked to increased amygdala activity and has been identified as a risk allele for depressive disorders.
|
25711941 |
2015 |
|
Depressive disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice.
|
25583186 |
2015 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Commonly studied candidate genes associated with depression include those that influence serotonin (SLC6A4), dopamine (COMT), or neuroplasticity (BDNF, NTRK3).
|
26055783 |
2015 |
|
Depressive disorder
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Social support and the serotonin transporter genotype (5-HTTLPR) moderate levels of resilience, sense of coherence, and depression.
|
25989139 |
2015 |
|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the context of childhood neglect, among BDNF Met-carriers, s-allele carriers of 5-HTTLPR reported significantly higher depression than l/l homozygotes, whereas a differential relation of 5-HTTLPR genotype to depression was not seen among BDNF Val/Val homozygotes.
|
26070769 |
2015 |